Navigation Links
Novel insights into the evolution of protein networks
Date:3/21/2013

Starting point of the joint research project was a hypothesis emphasising the importance of the duplication of proteins in the course of evolution. If the gene encoding a protein is duplicated in the genome, which often happens in evolution, original and copy will interact with the same partners in the protein network. Once original and copy diverge over time, novel proteins with individual features and own partners in the network will emerge. Interactions in the network would thereby not be newly created but evolve through duplication and divergence from simpler ancestors.

Protein networks of extinct ancestors were reconstructed

The two workgroups around bioinformatician Thomas Rattei and physicist Hernan Makse tested and improved this hypothesis in an elaborate computational experiment. They developed a novel method for the reconstruction of protein networks of extinct evolutionary ancestors from the genomes and networks of present-day species. Data of seven species from various domains of life were used: from bacteria, fungi, plants, animals to humans.

Present-day networks complex structures through simple mechanisms

The comparison of these reconstructed ancient protein networks yielded a surprisingly clear result: the present-day networks can be explained almost exclusively through the mechanism of duplication and divergence. Novel interactions between proteins emerge on rare occasions. This principle seems to be universal in the evolution of species as it was confirmed by the data obtained from all species analysed in this study. This principle could also explain the dynamics of other biological networks and it explains special features of protein networks such as self-similarity (fractality) in a straightforward way.

Useful for the interpretation of genome sequences and evolutionary biology

The results of the joint research project of the University of Vienna and CUNY wi
'/>"/>

Contact: Thomas Rattei
thomas.rattei@univie.ac.at
43-142-777-6210
University of Vienna
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. UMass Amherst researchers reveal mechanism of novel biological electron transfer
2. Novel treatment approach for bladder pain using a herpes simplex virus vector reported
3. Scientists discover novel chemical that controls cell behavior
4. BGI Tech develops novel Ultra-Deep de novo assembly solution for heterozygous genomes
5. Novel storage mechanism allows command, control of memory
6. Brown unveils novel wireless brain sensor
7. Novel combination therapy shuts down escape route, killing glioblastoma tumor cells
8. Novel coronavirus well-adapted to humans, susceptible to immunotherapy
9. Novel test streamlines testing for Huntington Disease
10. New tool for mining bacterial genome for novel drugs
11. Novel aptamer boosts T cell-based immune response to therapeutic vaccines
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Novel insights into the evolution of protein networks
(Date:3/10/2015)... NEW YORK , March 10, 2015  Continuing ... and the Unexpected, Hammacher Schlemmer introduces The Eye ... user,s identity before granting access to secure websites or ... trusted to verify travelers at international borders, the device ... 240 distinctive pattern points of the iris, converting them ...
(Date:3/4/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/48tj8z/global_biometrics ) ... Biometrics Market Forecast and Opportunities, 2020" report ... biometric authentication systems is projected to grow at ... The driving forces for this highly competitive ... and constant development in technology. In 2014, government ...
(Date:2/25/2015)... LITTLE ROCK, Ark. , Feb. 25, 2015 ... of software and billing in the Health and ... software as well as to MYiCLUBonline.  The latest ... MYiCLUBonline and the inclusion of cardless check-in via ... demonstrated for the first time through interactive displays ...
Breaking Biology News(10 mins):Hammacher Schlemmer Introduces The Eye Scanning Password Authenticator 2Global Biometrics Market Forecast and Opportunities, 2020 2Global Biometrics Market Forecast and Opportunities, 2020 3ABC Financial Unveils New Software Enhancements 2ABC Financial Unveils New Software Enhancements 3
... used, for example, to functionally characterize ,orphan, receptors those ... and thus qualify them as potential targets for drug ... libraries in order to identify and refine potential new drugs ... and are responsible for sensing the presence of hormones and ...
... COLUMBIA, Mo. If finding the cure for a ... subject of a detective show, University of Missouri Chemistry Professor ... using high-tech equipment to make a model that could eventually ... College of Arts and Science, has joined forces with Pablo ...
... CINCINNATI - A newly identified regulatory process affecting the ... new approaches to explore the causes of autoimmunity and ... of publication in Proceedings of the National Academy ... Children,s Hospital Medical Center report a novel process of ...
Cached Biology News:OGI invests in drug discovery at InDanio Bioscience 2X-ray diffraction may play key role in stopping 'kissing bug,' fungus 2Novel regulatory process for T cells may help explain immune system diseases 2
(Date:3/26/2015)... Ale Gicqueau, Founder and President of Clinovo, will ... Align Technology, on “ Conducting Postmarket Registries - Rationale ... Conference and Exhibition on April 25th through April 28th ... poster presentation, Ale Gicqueau and Victor Chen will discuss ... the requirements and resources to conduct the registry, as ...
(Date:3/25/2015)... Optimal Research, LLC has been nominated as ... "Best Clinical Site or Trial Network". This ... selected as a nominee in this ViE award category ... distinction in 2014. The ViE awards were created to ... positive contributions of companies and individuals in the vaccine ...
(Date:3/25/2015)... CAMBRIDGE, Mass. and REYKJAVIK, Iceland ... comprehensive capabilities for using the genome to create better medicine, ... of the largest studies of whole-genome data yet undertaken. ... Nature Genetics – are built around the ... by a team of deCODE scientists led by Kari ...
(Date:3/25/2015)... Researchers at Ancon Medical Inc. have ... enable broader and less invasive screening for cancer, ... breath screen. The Minnesota-based medical device maker will ... Administration (FDA) approval process and is targeting a ... Tagging device. , Ancon Medicals nanoparticle breakthrough comes ...
Breaking Biology Technology:Clinovo Presents at ACRP 2015 in Salt Lake City, Utah on April 25th-28th 2Clinovo Presents at ACRP 2015 in Salt Lake City, Utah on April 25th-28th 3Optimal Research Nominated 2015 Vaccine Industry Excellence (ViE) Award 2Landmark deCODE Studies Demonstrate the Power of Truly Big Genomics for Improving Medicine Worldwide 2Ancon Medical Researchers Make Nanotechnology Breakthrough for Disease Screening Technology 2Ancon Medical Researchers Make Nanotechnology Breakthrough for Disease Screening Technology 3
... Inc. (Nasdaq: OREX ), a biopharmaceutical company ... Jay Hagan has joined the organization as Senior Vice ... over 15 years of biotechnology operating and business development ... a significant number of important transactions. We are ...
... LYNBROOK, N.Y., May 11 BioSpecifics Technologies Corp. ... developing first in class collagenase-based products, today announced ... March 31, 2009. "The FDA,s recent acceptance of ... Priority Review for Dupuytren,s disease represents the culmination ...
... Barnard, has been awarded the International Union of Pure ... Computational Physics. , The award acknowledges Dr Barnard as ... the structures, shapes and crystal structures of materials at ... Melbourne Institute of Technology (RMIT) University in 2001 ...
Cached Biology Technology:Orexigen(R) Therapeutics Announces Jay Hagan as Senior Vice President, Corporate Development and Strategy 2Orexigen(R) Therapeutics Announces Jay Hagan as Senior Vice President, Corporate Development and Strategy 3Orexigen(R) Therapeutics Announces Jay Hagan as Senior Vice President, Corporate Development and Strategy 4BioSpecifics Technologies Corp. Reports First Quarter 2009 Financial Results 2BioSpecifics Technologies Corp. Reports First Quarter 2009 Financial Results 3BioSpecifics Technologies Corp. Reports First Quarter 2009 Financial Results 4BioSpecifics Technologies Corp. Reports First Quarter 2009 Financial Results 5Big prize for 'small science' physicist 2
Request Info...
Request Info...
Detect and measure levels of mouse IgG2b antibody isotypes quickly and easily....
Detect and measure levels of mouse IgG3 antibody isotypes quickly and easily....
Biology Products: