Navigation Links
Novel enzyme from tiny gribble could prove a boon for biofuels research
Date:6/18/2013

Researchers from the United Kingdom, the Energy Department's National Renewable Energy Laboratory (NREL), and the University of Kentucky have recently published a paper describing a novel cellulose-degrading enzyme from a marine wood borer Limnoria quadripunctata, commonly known as the gribble.

Gribbles are biologically intriguing because they exhibit a relatively unique ability to produce their own enzymes instead of using symbiotic microbes to break down the biomass they eat. New biomass-degrading enzymes from novel sources such as the gribble may prove beneficial to the biofuels industry.

Gribbles are 1-3 millimeters in length, but collectively they bore through wood quickly, and are responsible for significant natural and man-made marine timber damage around the world. Scientists at Universities of Portsmouth and York in the United Kingdom and the University of Kentucky in the United States, with researchers from NREL, are hoping to turn that special talent into a source of novel enzymes for the biofuels industry.

A paper describing the crystal structure of a key enzyme produced by the gribble appears online in Proceedings of the National Academy of Sciences of the United States of America. http://www.pnas.org/content/early/2013/05/31/1301502110.short

Gribbles live in inter-tidal zones and, similar to termites, they burrow into wood. Gribbles, unlike termites or many other animals including people, do not rely on gut bacteria to make enzymes to aid their digestion. Gribbles instead exhibit a sterile gut, and secrete their own enzymes into their guts made in a special organ termed the heptopancreas that runs the entire length of their body.

Interestingly, several of the enzymes produced by gribbles are in the same important enzyme classes that are typically harvested from fungi in the biosphere for industrially deconstructing the cellulose in biomass. The gribble enzymes hold promise of tolerating salts much better, likely due to the fact they evolved in a marine environment. This unique adaptation may have beneficial implications for the ability of the gribble enzymes to more efficiently operate in a high-solids, industrial environment, breaking biomass down more effectively into sugars, which can then be converted into ethanol or a hydrocarbon fuel to replace gasoline, diesel, or jet fuel.

The biofuels industry needs tough, efficient enzymes that are tolerant of industrial processes. "For biochemical conversion with enzymes, industry needs to push up to very high solids, with very little water around," NREL Senior Scientist Gregg Beckham, one of the co-authors, said. "The structure of the gribble enzyme reveals new evolutionary adaptations that may suggest mechanisms for producing more robust, industrial enzymes for high-solids loadings environments."

NREL ran computer simulations and aided in the structural and biochemical analysis of the enzyme.

The work leading to the paper provided deeper understanding of how the organism adapts and survives. NREL and UK scientists are now examining how features of the gribble enzymes could be incorporated into industrially relevant enzymes and settings.


'/>"/>

Contact: David Glickson
david.glickson@nrel.gov
303-275-4097
DOE/National Renewable Energy Laboratory
Source:Eurekalert

Related biology news :

1. Novel biomarkers improve diagnosis in rheumatoid arthritis
2. Patent awarded today to NJIT for novel use of water jets to create high tensile strength alloy parts
3. U of M researchers find novel gene correction model for epidermolysis bullosa
4. University of Maryland School of Medicine researchers find potential novel treatment for influenza
5. Novel screening tests for liver cancer
6. BUSM study reveals novel mechanism by which UVA contributes to photoaging of skin
7. Novel therapeutic approaches to cure chronic HBV infection
8. Development of novel therapies for endothelial damage may heal atherosclerotic plaques
9. Middle-schoolers discover novel chemical bond
10. A novel surface marker helps scientists fish out mammary gland stem cells
11. BUSM researchers identify novel approach to study COPD and treatment efficacy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/11/2017)... Research and Markets has announced the addition ... their offering. ... tracking market to grow at a CAGR of 30.37% during the ... 2017-2021, has been prepared based on an in-depth market analysis with ... its growth prospects over the coming years. The report also includes ...
(Date:4/5/2017)... April 5, 2017  The Allen Institute for Cell ... Explorer: a one-of-a-kind portal and dynamic digital window into ... data, the first application of deep learning to create ... cell lines and a growing suite of powerful tools. ... these and future publicly available resources created and shared ...
(Date:4/3/2017)... , April 3, 2017  Data captured ... engineering platform, detected a statistically significant association ... prior to treatment and objective response of ... potential to predict whether cancer patients will ... treatment, as well as to improve both pre-infusion ...
Breaking Biology News(10 mins):
(Date:10/9/2017)... ... October 09, 2017 , ... ... journal, Epilepsia, Brain Sentinel’s SPEAC® System which uses the surface electromyography (sEMG) ... tonic-clonic seizures (GTCS) using surface electromyography (sEMG). The prospective multicenter phase III ...
(Date:10/7/2017)... ... October 06, 2017 , ... ... ProxiMeta™ Hi-C metagenome deconvolution product, featuring the first commercially available Hi-C kit. ... to perform Hi-C metagenome deconvolution using their own facilities, supplementing the company’s ...
(Date:10/6/2017)... ... October 06, 2017 , ... The HealthTech Venture Network ... at their fourth annual Conference where founders, investors, innovative practitioners and collaborators are ... pitch competition showcasing early stage digital health and med tech companies. , This ...
(Date:10/5/2017)... ... October 05, 2017 , ... LabRoots , the ... from around the world, is giving back to cancer research with a month-long promotion ... , Now through October 31, shoppers can use promo code PinkRibbon to get 10 ...
Breaking Biology Technology: