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Novel compounds show early promise in treatment of Parkinson's, Huntington's, Alzheimer's

Investigators at Southern Methodist University and The University of Texas at Dallas have discovered a family of small molecules that shows promise in protecting brain cells against nerve-degenerative diseases such as Parkinson's, Alzheimer's and Huntington's, which afflict millions.

Dallas-based startup EncephRx, Inc. was granted the worldwide license to the jointly owned compounds. A biotechnology and therapeutics company, EncephRx will develop drug therapies based on the new class of compounds as a pharmaceutical for preventing nerve-cell damage, delaying onset of degenerative nerve disease and improving symptoms.

Treatments currently in use don't stop or reverse degenerative nerve diseases, but instead only alleviate symptoms, sometimes with severe side effects. If proved effective and nontoxic in humans, EncephRx's small-molecule pharmaceutical would be the first therapeutic tools able to stop affected brain cells from dying.

"Our compounds protect against neurodegeneration in mice," said synthetic organic chemist Edward R. Biehl, the Chemistry Department professor who led development of the compounds at SMU. "Given successful development of the compounds into drug therapies, they would serve as an effective treatment for patients with degenerative brain diseases."

EncephRx initially will focus its development and testing efforts toward Huntington's disease and potentially will have medications ready for human trials in two years, said Aaron Heifetz, CEO at EncephRx.

Compounds developed by SMU and UTD collaboration

Biehl developed the compounds in collaboration with UT Dallas biology professor Santosh R. D'Mello, whose laboratory has been studying the process of neurodegeneration for several years.

"Additional research needs to be done, but these compounds have the potential for stopping or slowing the relentless loss of brain cells in diseases such as Alzheimer's and Parkinson's," said

Contact: Margaret Allen
Southern Methodist University

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Novel compounds show early promise in treatment of Parkinson's, Huntington's, Alzheimer's
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