Navigation Links
Novel compounds show early promise in treatment of Parkinson's, Huntington's, Alzheimer's
Date:12/7/2010

Investigators at Southern Methodist University and The University of Texas at Dallas have discovered a family of small molecules that shows promise in protecting brain cells against nerve-degenerative diseases such as Parkinson's, Alzheimer's and Huntington's, which afflict millions.

Dallas-based startup EncephRx, Inc. was granted the worldwide license to the jointly owned compounds. A biotechnology and therapeutics company, EncephRx will develop drug therapies based on the new class of compounds as a pharmaceutical for preventing nerve-cell damage, delaying onset of degenerative nerve disease and improving symptoms.

Treatments currently in use don't stop or reverse degenerative nerve diseases, but instead only alleviate symptoms, sometimes with severe side effects. If proved effective and nontoxic in humans, EncephRx's small-molecule pharmaceutical would be the first therapeutic tools able to stop affected brain cells from dying.

"Our compounds protect against neurodegeneration in mice," said synthetic organic chemist Edward R. Biehl, the Chemistry Department professor who led development of the compounds at SMU. "Given successful development of the compounds into drug therapies, they would serve as an effective treatment for patients with degenerative brain diseases."

EncephRx initially will focus its development and testing efforts toward Huntington's disease and potentially will have medications ready for human trials in two years, said Aaron Heifetz, CEO at EncephRx.

Compounds developed by SMU and UTD collaboration

Biehl developed the compounds in collaboration with UT Dallas biology professor Santosh R. D'Mello, whose laboratory has been studying the process of neurodegeneration for several years.

"Additional research needs to be done, but these compounds have the potential for stopping or slowing the relentless loss of brain cells in diseases such as Alzheimer's and Parkinson's," said
'/>"/>

Contact: Margaret Allen
mallen@smu.edu
214-768-7664
Southern Methodist University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. GEN co-sponsors roundtable discussion on novel bioremediation techniques
2. In the lab, engineers novel liquid provides a solid fix for broken bones
3. Novel services for tropical forest monitoring with satellite
4. In new novel, secret discovery threatens company and damages love affair
5. Dow Agrosciences licenses exclusive novel crop enhancement technology
6. Novel regulatory process for T cells may help explain immune system diseases
7. Novel protein critical for cellular proliferation discovered
8. Novel reference material to standardize gene therapy applications
9. Scripps Research scientists develop novel test that identifies river blindness
10. Interfering with a double-edged sword: novel anti-inflammatory functions for interferons
11. Novartis and collaborators discover novel antimalarial drug candidate
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Novel compounds show early promise in treatment of Parkinson's, Huntington's, Alzheimer's
(Date:4/13/2015)... CHICAGO , April 13, 2015  higi, a ... with ways to more fully engage with their communities ... its industry-leading, privacy protected and secure API.  ... API enables the most accessible, affordable, and convenient vehicle ... The API will ...
(Date:4/9/2015)... Calif. , April 9, 2015 Synaptics ... interface solutions, announced today that it will report financial ... Thursday, April 23, 2015, after the close of market. ... analysts and investors at 2:00 p.m. PT (5:00 p.m. ... To participate on the live call, analysts ...
(Date:4/6/2015)... , Apr. 6, 2015 NXT-ID, Inc. (NASDAQ: ... biometric authentication company focused on the growing mobile ... provisional patent 62/143028 for MINIATURE, MULTI-PURPOSE ... TRANSFER  NXT-ID introduces a new revolutionary ... patent surrounds the use of miniature antenna modules ...
Breaking Biology News(10 mins):higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 2higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 3Synaptics to Report Third Quarter Results on April 23 2NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 2NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 3NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 4
... York, NY) The Parkinson,s Disease Foundation (PDF) is pleased ... the potential of individualized stem cell therapy to treat ... research of Marina Emborg, M.D., Ph.D., and Su-Chun Zhang, ... This award was chosen as part of PDF,s ...
... DCGeorgetown University Medical Center and Oak Ridge ... the institutions that formalizes their research relationship ... in the areas of structural biology, systems ... The Comprehensive Research and Development Agreement ...
... 23, 2008 -- Eight Oak Ridge National Laboratory nanomanufacturing ... Department of Energy,s Industrial Technologies Program. The awards, ... $1.6 million to partners, are the result of a ... The awards are for the following projects: ...
Cached Biology News:Parkinson's Disease Foundation announces award of $150,000 2GUMC and Oak Ridge National Labs announce unique research partnership 2GUMC and Oak Ridge National Labs announce unique research partnership 3ORNL nanotechnologies big winners in DOE call 2ORNL nanotechnologies big winners in DOE call 3
(Date:5/1/2015)... Md. and RESEARCH TRIANGLE PARK, N.C. ... UTHR ) announced today that Roger Jeffs , ... provide an overview and update on the company,s business at ... in Boston, Massachusetts . The ... 3:30 PM Eastern Time, and can be accessed via a ...
(Date:4/30/2015)... WARREN, N.J. , April 30, 2015  Roka ... company focused on providing advanced testing solutions for the ... financial results for the first quarter of 2015 on ... markets. Roka Bioscience will also host a ... 7, 2015 to discuss its first quarter financial results. ...
(Date:4/30/2015)... South San Francisco, CA (PRWEB) April 30, 2015 ... revenues for the first quarter of 2015 were $4.4 million, ... The net loss for the first quarter was $8.9 ... compared to a net loss for the same period in ... diluted share. As of March 31, 2015, cash, cash equivalents ...
(Date:4/30/2015)... Nitto Avecia, a leading biotechnology manufacturer and ... production capability to serve biotechnology pharmaceutical clients. A ... continues to drive Nitto Avecia to enhance synthesis ... , In Fall 2014, Nitto Avecia first ... its Milford, MA facility, which is recognized as ...
Breaking Biology Technology:Roka Bioscience to Report First Quarter 2015 Financial Results On May 7, 2015 2Cytokinetics, Incorporated Reports First Quarter 2015 Financial Results 2Cytokinetics, Incorporated Reports First Quarter 2015 Financial Results 3Cytokinetics, Incorporated Reports First Quarter 2015 Financial Results 4Cytokinetics, Incorporated Reports First Quarter 2015 Financial Results 5Cytokinetics, Incorporated Reports First Quarter 2015 Financial Results 6Cytokinetics, Incorporated Reports First Quarter 2015 Financial Results 7Cytokinetics, Incorporated Reports First Quarter 2015 Financial Results 8Biotechnology Manufacturer Nitto Avecia Expands Capacity to Meet Client Demand 2
... Europe Trails in Expanded IIIP Innovation Confidence Index , ... San Francisco, ... was largely unaffected by the drop in consumer confidence last year, according ... to cover every region of the world and released publicly today. ...
... at the U.S. Department of Energy (DOE) Joint Genome Institute ... analysis of the complete genome of sorghum, a major food ... The genome data will aid scientists in optimizing sorghum ... but also for biofuels production. The comparative analysis of ...
... Endo Pharmaceuticals Inc. (Nasdaq: ENDP ), ... results on February 27, 2009 and will host ... that day to discuss these results. David P. ... Chief Operating Officer and Blaine Davis, Vice President, Corporate ...
Cached Biology Technology:Global Confidence in Innovation Holds Despite Economy 2Global Confidence in Innovation Holds Despite Economy 3Global Confidence in Innovation Holds Despite Economy 4Scientists publish complete genetic blueprint of key biofuels crop 2Endo Pharmaceuticals to Announce Fourth Quarter and 2008 Full-Year Financial Results on February 27, 2009 2
Amino-acids and Derivatives Rabbit Anti-conjugated L-isoleucine Polyclonal Antibody...
Anti-MMP-25 (Membrane-type MMP-6, Mt6MMP), hinge region; rabbit host...
PPIF Antibody...
Rabbit polyclonal to FLIP ( Abpromise for all tested applications). entrezGeneID: 8837 SwissProtID: O15519...
Biology Products: