Navigation Links
Novel biomarkers improve diagnosis in rheumatoid arthritis
Date:6/14/2013

Madrid, Spain, 12 June 2013: Data presented at EULAR 2013, the Annual Congress of the European League Against Rheumatism, show that novel antibody biomarkers could significantly improve diagnosis in rheumatoid arthritis (RA).

Four candidate biomarkers UH-RA.1, UH-RA.9, UH-RA.14 and UH-RA.21 were investigated; as a group they demonstrated 85% specificity for RA, and were present in both early and seronegative disease, with 36% of early RA and 24% of RF- and ACCP -negative patients testing positive.

RA is a chronic autoimmune disease characterised by inflammation of the joints and tendons. As the disease progresses it can cause pain, stiffness, joint destruction and deformity, and reduce quality of life, life expectancy and physical function.

"Early detection is imperative; if treated early, patients have a more than 50% chance of achieving remission3 yet one third of patients test negative to RF and ACCP. Antibody reactivity against our candidate biomarkers in both early and seronegative RA patients implies that they could significantly help to improve diagnosis and patient outcomes," said lead author of the study Liesbeth M De Winter, Biomedical Research Institute, Hasselt University, Diepenbeek, Belgium.

Antibody reactivity was measured in a cohort of 127 RA patients, 97 healthy controls, 90 rheumatic controls (including psoriatic arthritis, ankylosing spondylitis, osteoarthritis and Sjgren's syndrome patients) and a validation cohort of 165 RA patients. Amongst the 292 RA patients, 34% could not be identified using the current diagnostic biomarkers RF and ACCP.

"These data show that our candidates, in combination with existing biomarkers, could help close the diagnostic gap in RA. In addition, significant associations with inflammatory factors and the presence of erosions indicate a tangible prognostic potential," De Winter concluded.


'/>"/>

Contact: eularpressoffice@cohnwolfe.com
eularpressoffice@cohnwolfe.com
44-020-733-15364
European League Against Rheumatism
Source:Eurekalert

Page: 1

Related biology news :

1. Patent awarded today to NJIT for novel use of water jets to create high tensile strength alloy parts
2. U of M researchers find novel gene correction model for epidermolysis bullosa
3. University of Maryland School of Medicine researchers find potential novel treatment for influenza
4. Novel screening tests for liver cancer
5. BUSM study reveals novel mechanism by which UVA contributes to photoaging of skin
6. Novel therapeutic approaches to cure chronic HBV infection
7. Development of novel therapies for endothelial damage may heal atherosclerotic plaques
8. Middle-schoolers discover novel chemical bond
9. A novel surface marker helps scientists fish out mammary gland stem cells
10. BUSM researchers identify novel approach to study COPD and treatment efficacy
11. Predicting the next eye pathogen; analysis of a novel adenovirus
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... , Dec. 15, 2014 Research and Markets ... the "Samsung Galaxy S5 - Home Button Synaptics ... http://photos.prnewswire.com/prnh/20130307/600769 ... iPhone 5S, Samsung introduces for the first time a ...
(Date:12/17/2014)... Dec. 16, 2014  Automation is fundamentally transforming the travel ... international borders. Over the past decade, ePassports, biometric readers, ... self process through border control via eGates and Automated ... airports, seaports, and land borders across the globe. ...
(Date:12/11/2014)... Dec. 10, 2014  Data Sciences International (DSI), the ... a new series of digital telemetry implants to ... M series, part of the PhysioTel™ Digital platform, ... possible physiologic data when incorporating functional endpoints into ...
Breaking Biology News(10 mins):Samsung Galaxy S5 - Home Button Synaptics Fingerprint Sensor Technology Analysis 2Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2New telemetry implants expected to change how large animal toxicology studies are conducted 2
... explosion in the number of people over the age of 50 ... of the population will be over the age of 50 and ... a warning call for health authorities and medical professionals who must ... diseases such as osteoporosis. In response to the need ...
... Texas, May 10, 2012 /PRNewswire-iReach/ -- WanderID ... in Western Travis County. Used to identify individuals who ... Alzheimer,s patients and young and/or special needs children, the ... responders, including the Lakeway Police Department [credit: KXAN video ...
... 9, 2012 While we often think of memory as ... are, little thought is given to the importance of forgetting ... "horrible memories department" or just reflects the minutia of day-to-day ... exactly how we forgetthe molecular, cellular, and brain circuit mechanisms ...
Cached Biology News:WanderID Launches Breakthrough ID Product for Children, Seniors 2Scripps Florida scientists identify neurotranmitters that lead to forgetting 2Scripps Florida scientists identify neurotranmitters that lead to forgetting 3
(Date:1/22/2015)... 22, 2015 Pipette.com has added the ... their comprehensive portfolio of Eppendorf products. , The Eppendorf ... a Centrifuge 5424/5424 R and receive the following:, ... Research plus or Eppendorf Reference 2 , ...
(Date:1/22/2015)... Selexis SA, a serial innovation company ... (RCBs) used for drug discovery to commercial manufacturing, announced ... Next-Generation Sequencing (NGS) data packages. The NGS ... by ensuring the integrity of the gene, validation of ...
(Date:1/22/2015)... Jan. 22. 2015  Varian Medical Systems (NYSE: VAR ... honored for its commitment to sustainability with inclusion on a ... the highest ranked healthcare equipment company among the Corporate Knights ... World Economic Forum at Davos, Switzerland . ...
(Date:12/24/2014)...  United Therapeutics Corporation (NASDAQ: UTHR ) announced ... has submitted a pre-market approval application to the U.S. ... Medtronic,s SynchroMed ® II implantable drug infusion system ... Therapeutics, Remodulin ® (treprostinil) Injection delivered intravenously to ...
Breaking Biology Technology:Eppendorf Announces Promotional Bundle Which Includes: Eppendorf Centrifuge 5424, 3-Pack of Pipettes, and Tips - Available Now at Pipette.com 2Selexis Generated Research Cell Banks Now Fully Sequenced Using Next-Generation Sequencing 2Varian Honored Among World's 100 Most Sustainable Corporations 2United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 2United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 3United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 4
... TEL AVIV, Israel, Jan. 31, 2012   InspireMD, Inc. ... medical device company focusing on the development and ... use in patients with Acute Myocardial Infarctions, today ... its Board of Directors as an independent director.  ...
... world, with the potential to create foldaway mobile phones, wallpaper-thin ... finding at the University of Manchester gives graphene,s potential a ... distilling alcohol. In a report published in Science ... that graphene-based membranes are impermeable to all gases and liquids ...
... technique builds on previous research in which microbubbles were used ... an oil which can be processed to create a useful ... alternative to fossil fuels and algae, in particular, has the ... however, there has been no cost-effective method of harvesting and ...
Cached Biology Technology:InspireMD Appoints Dr. James Barry to Its Board of Directors 2InspireMD Appoints Dr. James Barry to Its Board of Directors 3InspireMD Appoints Dr. James Barry to Its Board of Directors 4Supermaterial goes superpermeable 2Microbubbles provide new boost for biofuel production 2
...
Human Regulatory T cell Staining Kit #2 (w/ APC Foxp3 PCH101, FITC CD4, PE CD25)...
Goat anti-VAV2 Class: Antibody Product Group: Miscellaneous Antibody...
Rabbit polyclonal to M13 Bacteriophage Coat Proteins ( Abpromise for all tested applications)....
Biology Products: