Navigation Links
Novel biomarkers improve diagnosis in rheumatoid arthritis
Date:6/14/2013

Madrid, Spain, 12 June 2013: Data presented at EULAR 2013, the Annual Congress of the European League Against Rheumatism, show that novel antibody biomarkers could significantly improve diagnosis in rheumatoid arthritis (RA).

Four candidate biomarkers UH-RA.1, UH-RA.9, UH-RA.14 and UH-RA.21 were investigated; as a group they demonstrated 85% specificity for RA, and were present in both early and seronegative disease, with 36% of early RA and 24% of RF- and ACCP -negative patients testing positive.

RA is a chronic autoimmune disease characterised by inflammation of the joints and tendons. As the disease progresses it can cause pain, stiffness, joint destruction and deformity, and reduce quality of life, life expectancy and physical function.

"Early detection is imperative; if treated early, patients have a more than 50% chance of achieving remission3 yet one third of patients test negative to RF and ACCP. Antibody reactivity against our candidate biomarkers in both early and seronegative RA patients implies that they could significantly help to improve diagnosis and patient outcomes," said lead author of the study Liesbeth M De Winter, Biomedical Research Institute, Hasselt University, Diepenbeek, Belgium.

Antibody reactivity was measured in a cohort of 127 RA patients, 97 healthy controls, 90 rheumatic controls (including psoriatic arthritis, ankylosing spondylitis, osteoarthritis and Sjgren's syndrome patients) and a validation cohort of 165 RA patients. Amongst the 292 RA patients, 34% could not be identified using the current diagnostic biomarkers RF and ACCP.

"These data show that our candidates, in combination with existing biomarkers, could help close the diagnostic gap in RA. In addition, significant associations with inflammatory factors and the presence of erosions indicate a tangible prognostic potential," De Winter concluded.


'/>"/>

Contact: eularpressoffice@cohnwolfe.com
eularpressoffice@cohnwolfe.com
44-020-733-15364
European League Against Rheumatism
Source:Eurekalert

Page: 1

Related biology news :

1. Patent awarded today to NJIT for novel use of water jets to create high tensile strength alloy parts
2. U of M researchers find novel gene correction model for epidermolysis bullosa
3. University of Maryland School of Medicine researchers find potential novel treatment for influenza
4. Novel screening tests for liver cancer
5. BUSM study reveals novel mechanism by which UVA contributes to photoaging of skin
6. Novel therapeutic approaches to cure chronic HBV infection
7. Development of novel therapies for endothelial damage may heal atherosclerotic plaques
8. Middle-schoolers discover novel chemical bond
9. A novel surface marker helps scientists fish out mammary gland stem cells
10. BUSM researchers identify novel approach to study COPD and treatment efficacy
11. Predicting the next eye pathogen; analysis of a novel adenovirus
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/25/2016)... 25, 2016   Unisys Corporation (NYSE: UIS ) ... Kennedy (JFK) International Airport, New York City , ... imposters attempting to enter the United States ... pilot testing of the system at Dulles last ... at JFK during January 2016. --> pilot testing ...
(Date:1/20/2016)... , Jan. 20, 2016 A market that ... directly benefit from the explosion in genomics knowledge. Learn ... Sound Research. A range of dynamic trends are pushing ... - personalized medicine - pharmacogenomics - pathogen evolution - ... large markets - greater understanding of the role of ...
(Date:1/13/2016)... ALBANY, New York , January 13, 2016 /PRNewswire/ ... Transparency Market Research has published a new market report ... Share, Growth, Trends, and Forecast, 2015 - 2023. According to ... mn in 2014 and is anticipated to reach US$1,625.8 ... from 2015 to 2023. In terms of volume, the ...
Breaking Biology News(10 mins):
(Date:2/11/2016)... 11, 2016  Bioethics International, a not-for-profit organization focused on ... marketed and made accessible to patients around the world, today ... named the publication of the Good Pharma Scorecard ... also featured as one of BMJ Open ,s ,Most ... that are most frequently read. Ed Sucksmith , ...
(Date:2/11/2016)...  Wellcentive today announced it has been selected ... -based community care organization (CCO) with more than ... reporting and care management solutions and services. Wellcentive,s ... quality managers, analysts and care managers while providing ... FamilyCare members. Oregon ...
(Date:2/11/2016)... , Feb. 11, 2016  Dovetail Genomics™ LLC ... its beta program for a planned metagenomic genome assembly ... the company,s metagenomic genome assembly method in a talk ... Genome Biology & Technology conference in Orlando, ... these highly complex datasets is difficult. Using its proprietary ...
(Date:2/11/2016)...   BioInformant announces the February 2016 release ... Opportunities, Tools, and Technologies – Market Size, Segments, Trends, ... The first and only market ... BioInformant has more than a decade of historical information ... stem cell type. This powerful 175 page global strategic ...
Breaking Biology Technology: