Navigation Links
Novel bioactive peptides promote wound healing in vivo
Date:2/24/2012

BOSTON (February 23, 2012, 5:00 pm ET) Researchers have combined bioactive peptides to successfully stimulate wound healing. The in vitro and in vivo study, published today in PLoS ONE, demonstrates that the combination of two peptides stimulates the growth of blood vessels and promotes re-growth of tissue. Further development of these peptides could lead to a new treatment for chronic and acute wounds.

The team tested a newly-created peptide, UN3, in pre-clinical models aimed to simulate impaired wound healing as is seen in patients with peripheral vascular diseases or uncontrolled diabetes. The peptide led to a 50% increase in blood vessel wall development, a 250% increase in growth of blood vessels, and a 300% increase in cell migration in response to the injury.

"Using double-blinded in vivo experiments, we then applied the wound-healing peptide UN3 with a peptide created during a previous study, named comb1. We found that, together, the two out-performed all control groups, including the only FDA-approved growth factor-containing drug for treating diabetic wounds, becaplermin," said first author, Tatiana Demidova-Rice, PhD, now a graduate of the cell, molecular and developmental biology program at the Sackler School of Graduate Biomedical Sciences.

In December 2010, Herman and Demidova-Rice identified several peptides from a Clostridium histolyticum collagenase treatment of bio-synthesized extracellular matrix. The investigators then went on to cull key peptides and, from these, they created the peptide, comb1, possessing several strategic features, including its ability to stimulate angiogenesis by increasing blood vessel growth by 200% in vitro.

The second wound-healing peptide, UN3, identified in the current study, was created and modified from two naturally occurring peptides that are normally present in trace amounts and found in human platelet-rich plasma.

"The confirmation that these peptides could act synergistically to improve human wound healing moves our research one significant step closer to clinical application. We hope that someday soon, we may be able to help transform the way in which wound care is being delivered in civilian and combat settings," said Ira Herman, PhD, professor of molecular physiology and pharmacology at Tufts University School of Medicine. Professor Herman is director, molecular and cellular physiology graduate program at the Sackler School of Graduate Biomedical Sciences and director, Center for Innovations in Wound Healing Research, Tufts University.

"The wound-healing peptides should also prove strategic as we continue developing 'smart' devices or fully-vascularized living tissue constructs for burn patients or those patients suffering with diabetic plantar or venous stasis ulcers. Clinical trials using the peptides will be the next step," Herman continued. Tufts University has filed patent applications related to the wound-healing peptides.

Tufts Center for Innovations in Wound Healing Research brings together experts from Tufts' medical, dental, veterinary and engineering schools, as well as Tufts Medical Center and local research institutes with a focus on creating innovative wound healing therapeutics as well as fully-vascularized organ constructs for personalized regenerative medicine.

Demidova-Rice is now at the Edwin L. Steele Laboratory for Tumor Biology in the department of Radiation Oncology at Massachusetts General Hospital. Additional authors include Lindsey Wolf, BS, formerly a research assistant at TUSM, now a graduate student working towards a PhD degree in the department of molecular genetics and microbiology at the University of Texas at Austin; Jeffry Deckenback, PhD, who was a postdoctoral fellow in the Herman lab while the work was being carried out; and Michael R. Hamblin, PhD, a principal investigator at the Wellman Center for Photomedicine at Massachusetts General Hospital and associate professor in the department of dermatology at Harvard Medical School.


'/>"/>

Contact: Siobhan E. Gallagher
siobhan.gallagher@tufts.edu
617-636-6586
Tufts University, Health Sciences Campus
Source:Eurekalert

Related biology news :

1. VTT searches for novel biomarkers and targets for preventing or treating Type 2 diabetes
2. Boston University researchers develop novel drug delivery system
3. Scientists uncover novel mechanism of glioblastoma development
4. UH Manoa researchers discover novel chemical route to form organic molecules
5. ISG15: A novel therapeutic target to slow breast cancer cell motility
6. Researchers discover novel anti-viral immune pathway in the mosquito
7. Chinese herbal medicine may provide novel treatment for alcohol abuse
8. Autism may be linked to abnormal immune system characteristics and novel protein fragment
9. Novel device removes heavy metals from water
10. Barracuda babies: Novel study sheds light on early life of prolific predator
11. Scientist-novelist back with second book at cell biology meeting
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/16/2017)... TEANECK, N.J. , May 16, 2017  Veratad ... leading provider of online age and identity verification solutions, ... the K(NO)W Identity Conference 2017, May 15 thru May ... Ronald Regan Building and International Trade Center. ... across the globe and in today,s quickly evolving digital ...
(Date:5/6/2017)... , May 5, 2017 RAM ... announced a new breakthrough in biometric authentication based ... quantum mechanical properties to perform biometric authentication. These new ... semiconductor material created by Ram Group and its ... entertainment, transportation, supply chains and security. Ram Group ...
(Date:4/19/2017)... 2017 The global military biometrics ... marked by the presence of several large global players. ... five major players - 3M Cogent, NEC Corporation, M2SYS ... nearly 61% of the global military biometric market in ... global military biometrics market boast global presence, which has ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... ... October 10, 2017 , ... ... antibody-drug conjugate (ADC) therapeutics, today confirmed licensing rights that give it exclusive ... a technology developed in collaboration with Children’s Hospital Los Angeles (CHLA). ...
(Date:10/10/2017)... CRUZ, Calif. , Oct. 10, 2017 ... grant from the NIH to develop RealSeq®-SC (Single Cell), ... kit for profiling small RNAs (including microRNAs) from single ... Analysis Program highlights the need to accelerate development of ... "New techniques for measuring ...
(Date:10/9/2017)... ... October 09, 2017 , ... The award-winning American Farmer television series ... 2018. American Farmer airs Tuesdays at 8:30aET on RFD-TV. , With global population ... challenge of how to continue to feed a growing nation. At the same time, ...
(Date:10/7/2017)... , ... October 06, 2017 ... ... experience providing advanced instruments and applications consulting for microscopy and surface analysis, ... in application consulting, Nanoscience Analytical offers a broad range of contract analysis ...
Breaking Biology Technology: