Navigation Links
Novel aptamer boosts T cell-based immune response to therapeutic vaccines
Date:1/23/2013

New Rochelle, NY, January 22, 2013A small compound called an aptamer that specifically targets and stimulates a human immune cell can greatly increase the effectiveness of an immunotherapeutic drug designed to destroy malignant or virus-infected cells. The development of a novel apatamer that recognizes activated T-lymphocytes and can boost the therapeutic effect of cell-based vaccines is described in an article in Nucleic Acid Therapeutics, a peer-reviewed journal from Mary Ann Liebert, Inc. publishers (http://www.liebertpub.com). The article is available on the Nucleic Acid Therapeutics website (http://www.liebertpub.com/nat).

Elizabeth Pratico, Bruce Sullenger, and Smita Nair, Duke University Medical Center, Durham, NC, describe the innovative techniques they used to create an aptamera short sequence of nucleic acidsthat binds to the human protein OX40, a costimulatory molecule present on the surface of already activated immune cells.

In the article "Identification and Characterization of an Agonistic Aptamer Against the T Cell Costimulatory Receptor, OX40," (http://online.liebertpub.com/doi/full/10.1089/nat.2012.0388) the researchers demonstrate that binding of the aptamer to OX40 on activated T cells enhances the cells' ability to proliferate and to produce the immunostimulatory cytokine interferon-gamma. The authors envision future studies that would evaluate the therapeutic potential of the human OX40 aptamer, which could be used to stimulate T cells during the production of patient-specific vaccines for use in cell therapy and personalized medicine.

"The therapeutic potential of aptamers has always been one of their most promising aspects," says Executive Editor Fintan Steele, PhD, SomaLogic, Inc., Boulder, CO. "This
'/>"/>

Contact: Vicki Cohn
vcohn@liebertpub.com
914-740-2100 x2156
Mary Ann Liebert, Inc./Genetic Engineering News
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Researchers discover novel therapy for Crohns disease
2. New clinical trial explores novel noninvasive colon cancer screening test
3. Notre Dame researchers using novel method to combat malaria drug resistance
4. Unique adaptations to a symbiotic lifestyle reveal novel targets for aphid insecticides
5. Key proteins newly discovered form and function may provide novel cancer treatment target
6. Novel discovery by NUS scientists paves the way for more effective treatment of cancers
7. London researchers discover novel mechanism involved in key immune response
8. Mexican rock heroes trial novel green trading system
9. VTT and GE Healthcare developing novel biomarkers to predict Alzheimers disease
10. Cleveland Clinic researchers receive $5 million grant to discover novel pathways to heart disease
11. Novel nano-structures to realize hydrogens energy potential
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Novel aptamer boosts T cell-based immune response to therapeutic vaccines
(Date:7/10/2014)... , July 7, 2014 ... Market Research "Electronic Access Control Systems Market Global Forecast, ... 2019," the global Electronic Access Control systems market was ... expected to grow at a CAGR of 12.6% from ... USD 31,187.8 million in 2019. Browse the ...
(Date:7/10/2014)... The genus Axinaea belongs to the large, mainly ... the ca. 5000 species in the family rely on bees ... pollinated by other insects or vertebrates. The flowers of ... twenty flowers and the petals of the different species are ... stand out based on the contrasting colours of their bulbous ...
(Date:7/10/2014)... or even improve the state of fisheries resources ... the Mediterranean has deteriorated over the past 20 ... species reported in the Cell Press journal ... for stringent monitoring of Mediterranean fishing activities, better ... in Mediterranean waters. , Their data show that ...
Breaking Biology News(10 mins):Electronic Access Control Systems Market is Expected to Reach USD 31.2 Billion Globally in 2019: Transparency Market Research 2Electronic Access Control Systems Market is Expected to Reach USD 31.2 Billion Globally in 2019: Transparency Market Research 3Electronic Access Control Systems Market is Expected to Reach USD 31.2 Billion Globally in 2019: Transparency Market Research 4Electronic Access Control Systems Market is Expected to Reach USD 31.2 Billion Globally in 2019: Transparency Market Research 5Novel type of bird pollination mechanism discovered in South America 2Mediterranean fish stocks show steady decline 2
... be enough to cool a hot temper, at least for a ... people who drank a glass of lemonade sweetened with sugar acted ... people who consumed lemonade with a sugar substitute. Researchers believe ... found in the bloodstream that provides energy for the brain. ...
... shows that anti-microbial medications are a common cause of ... (ALF), with women and minorities disproportionately affected. While ALF ... is unlikely; however liver transplantation offers an excellent survival ... published in the December issue of Hepatology , ...
... Washington, D.C. - U.S Energy Secretary Steven Chu today ... time to 57 innovative research projects - using computer ... would be impossible or impractical in the natural world. ... equal to 135,000 quad-core laptops, the research could, for ...
Cached Biology News:Researchers find link between sugar, diabetes and aggression 2Researchers find link between sugar, diabetes and aggression 3Researchers find link between sugar, diabetes and aggression 4Study finds anti-microbials a common cause of drug-induced liver injury and failure 2Could 135,000 laptops help solve the energy challenge? 2Could 135,000 laptops help solve the energy challenge? 3Could 135,000 laptops help solve the energy challenge? 4
(Date:7/10/2014)... Terascala, the industry leader in ... a former vice president of product management for Flexera ... of marketing. Terascala’s software when combined with leading compute ... highest performance and most reliable solutions for processing big ... channel expansion and broaden its product portfolio. His leadership ...
(Date:7/10/2014)... 2014 Robert Harman, DVM, Founder and CEO ... proud to announce the relaunch of his highly informative blog, ... series called “ What are Stem Cells ?” Dr. ... straightforward foundation in the basics of stem cell therapy so ... right type of treatment when considering regenerative medicine. , A ...
(Date:7/10/2014)... EvoDerma ’s NOOME Anti-Aging Motion has been upgraded ... with a second treatment cup to help prevent and smooth ... is thinner on the edges for a softer contact with ... uneven surfaces on the face, neck and décolleté. Choose to ... areas such as the cheeks and neck, or opt for ...
(Date:7/10/2014)... POINT, Ind. , July 10, 2014 ... expanded its use of capnography for respiratory ... growing group of healthcare leaders in embracing ... measures how effectively patients are breathing and ... depression occurs. By measuring the amount of ...
Breaking Biology Technology:Terascala Expands Executive Team 2Terascala Expands Executive Team 3Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 2Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 3Introducing a New Bonus Treatment Cup for EvoDerma’s NOOME Anti-Aging Motion 2Franciscan St. Anthony Health-Crown Point Underscores Patient Safety Commitment Through Expanded Use of Capnography 2
... Leader in, Animal Health and Strengthens Product Pipeline, Adding ... ... Projects, KENILWORTH, N.J., Nov. 19 Schering-Plough,Corporation (NYSE: ... BioSciences N.V., creating a stronger combined,company with broader human and animal ...
... discovery of a new way to manipulate light a million ... Science this week. , Using a special hollow-core photonic ... has opened the door to what could prove to be ... and trapping. , The team, led by Dr Fetah Benabid, ...
... The Committee for,Medicinal Products for Human Use ... (EMEA), granted Abbott (NYSE: ABT ) a ... treatment,of moderate to severe plaque psoriasis. Psoriasis will ... is a non-contagious, chronic autoimmune disease that causes,the ...
Cached Biology Technology:Schering-Plough Completes Acquisition of Organon BioSciences 2Schering-Plough Completes Acquisition of Organon BioSciences 3Schering-Plough Completes Acquisition of Organon BioSciences 4Schering-Plough Completes Acquisition of Organon BioSciences 5Discovery of a new way to manipulate light a million times more efficiently 2Abbott's HUMIRA(R) Receives Positive Opinion From EMEA for Treatment of Moderate to Severe Plaque Psoriasis 2Abbott's HUMIRA(R) Receives Positive Opinion From EMEA for Treatment of Moderate to Severe Plaque Psoriasis 3Abbott's HUMIRA(R) Receives Positive Opinion From EMEA for Treatment of Moderate to Severe Plaque Psoriasis 4Abbott's HUMIRA(R) Receives Positive Opinion From EMEA for Treatment of Moderate to Severe Plaque Psoriasis 5Abbott's HUMIRA(R) Receives Positive Opinion From EMEA for Treatment of Moderate to Severe Plaque Psoriasis 6Abbott's HUMIRA(R) Receives Positive Opinion From EMEA for Treatment of Moderate to Severe Plaque Psoriasis 7Abbott's HUMIRA(R) Receives Positive Opinion From EMEA for Treatment of Moderate to Severe Plaque Psoriasis 8
... Edited by John M. Walker (1996) ... successful analytical techniques for studying proteins ... protocol contains detailed, step-by-step instruction, timesaving ... and comprehensive lists of reagents and ...
RAT ANTI MOUSE TCR V BETA 7:RPE Immunogen: T-cell lymphoma TK1...
Human/Mouse/Rat Keap1 MAb (Clone 333116) Protein Family: Transcription Factor Regulators...
... 4503277 Accession Number: NP_001912.1 ... the nucleotide substrate for thymidylate synthetase. ... O = dUMP + NH 3 ... the Diseases: Benign Tumor; Leukemia; Escherichia ...
Biology Products: