Navigation Links
Novel aptamer boosts T cell-based immune response to therapeutic vaccines
Date:1/23/2013

New Rochelle, NY, January 22, 2013A small compound called an aptamer that specifically targets and stimulates a human immune cell can greatly increase the effectiveness of an immunotherapeutic drug designed to destroy malignant or virus-infected cells. The development of a novel apatamer that recognizes activated T-lymphocytes and can boost the therapeutic effect of cell-based vaccines is described in an article in Nucleic Acid Therapeutics, a peer-reviewed journal from Mary Ann Liebert, Inc. publishers (http://www.liebertpub.com). The article is available on the Nucleic Acid Therapeutics website (http://www.liebertpub.com/nat).

Elizabeth Pratico, Bruce Sullenger, and Smita Nair, Duke University Medical Center, Durham, NC, describe the innovative techniques they used to create an aptamera short sequence of nucleic acidsthat binds to the human protein OX40, a costimulatory molecule present on the surface of already activated immune cells.

In the article "Identification and Characterization of an Agonistic Aptamer Against the T Cell Costimulatory Receptor, OX40," (http://online.liebertpub.com/doi/full/10.1089/nat.2012.0388) the researchers demonstrate that binding of the aptamer to OX40 on activated T cells enhances the cells' ability to proliferate and to produce the immunostimulatory cytokine interferon-gamma. The authors envision future studies that would evaluate the therapeutic potential of the human OX40 aptamer, which could be used to stimulate T cells during the production of patient-specific vaccines for use in cell therapy and personalized medicine.

"The therapeutic potential of aptamers has always been one of their most promising aspects," says Executive Editor Fintan Steele, PhD, SomaLogic, Inc., Boulder, CO. "This
'/>"/>

Contact: Vicki Cohn
vcohn@liebertpub.com
914-740-2100 x2156
Mary Ann Liebert, Inc./Genetic Engineering News
Source:Eurekalert  

0

GOOD

Page: 1 2

Related biology news :

1. Researchers discover novel therapy for Crohns disease
2. New clinical trial explores novel noninvasive colon cancer screening test
3. Notre Dame researchers using novel method to combat malaria drug resistance
4. Unique adaptations to a symbiotic lifestyle reveal novel targets for aphid insecticides
5. Key proteins newly discovered form and function may provide novel cancer treatment target
6. Novel discovery by NUS scientists paves the way for more effective treatment of cancers
7. London researchers discover novel mechanism involved in key immune response
8. Mexican rock heroes trial novel green trading system
9. VTT and GE Healthcare developing novel biomarkers to predict Alzheimers disease
10. Cleveland Clinic researchers receive $5 million grant to discover novel pathways to heart disease
11. Novel nano-structures to realize hydrogens energy potential
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Novel aptamer boosts T cell-based immune response to therapeutic vaccines
(Date:5/24/2013)... Cancer cells spread and grow by avoiding detection and ... system can help to eliminate cancer cells; however, there ... ignore cancer cells. Regulatory T cells are immune cells ... this issue of the Journal of Clinical Investigation ... found that regulatory T cells that infiltrate tumors express ...
(Date:5/23/2013)... Frontiers in Plant Science , ... gene content and promoter evolution among grasses , ... of stretches of DNA that undergo little change in ... not code for any proteins. Some of these evolutionarily ... to regulate the expression of other genes or the ...
(Date:5/23/2013)... discovering the new mechanism by which estrogen suppresses lipid ... a potential new approach toward treating certain liver diseases. ... colleagues believe they are changing long-held views in the ... of the journal Science Signaling . , "The ... has been that only receptors located in the nucleus ...
Breaking Biology News(10 mins):Frontiers news briefs: May 23 2Frontiers news briefs: May 23 3UCI study reveals new mechanism for estrogen suppression of liver lipid synthesis 2
... do it. Bees do it. Even environmentally stressed fish do ... of Zoology is the first in the world to discover ... His research may provide the key to the survival of ... ocean ― currently threatened by global warming. In ...
... been hanging together rather than going it alone much longer ... of Volvox algae made the transition from being ... 200 million years ago, during the Triassic Period. ... included tree ferns, dinosaurs and early mammals. Previous estimates had ...
... flies mate, the females, genes are activated to roughly ... This is shown in a study at Uppsala University ... Journal of Evolutionary Biology .* Using a ... researchers at Uppsala University can show how fruit fly ...
Cached Biology News:Changing sexes on the sea floor 2How Volvox got its groove 2How Volvox got its groove 3
(Date:5/23/2013)... Die Übersetzungen wurden von PRNewswire ... der englischen Version handelt es sich um ... Teilnehmer einer groß angelegten Asthmaumfrage halten ihren Zustand für ... -Definition [1] als kontrolliert gelten können ... von vier Denkweisen zugeordnet werden können, die alle von ...
(Date:5/23/2013)... Graphite Metallizing Corporation announces a series ... stainless steel pillow blocks. This series combines the ... application and installation versatility of pillow blocks. , ... exceptionally well when submerged in water, water-soluble chemicals ... acids, alkalies, hydrocarbons, black liquor, and liquid gases. ...
(Date:5/23/2013)... PI’s new LPS-24 positioners are less ... travel range with closed-loop sensor resolution up to ... new positioners the ideal choice for high precision ... is also available. , More Information: Specifications ... found at: , http://www.physikinstrumente.com/en/products/prdetail.php?sortnr=1000745&prw-lps24 , Reference-Class ...
(Date:5/23/2013)... On April 19th the Center ... search for the growing antibiotic resistant bacteria that may ... year long study were released late last month showing ... over previous years. For those suffering from bacteria driven ... resistant bacteria in food, may eventually help breed acne ...
Breaking Biology Technology:Neue Forschungsergebnisse zeigen Verbindung zwischen suboptimaler Asthmaversorgung und Patienteneinstellungen in Europa auf 2Neue Forschungsergebnisse zeigen Verbindung zwischen suboptimaler Asthmaversorgung und Patienteneinstellungen in Europa auf 3Neue Forschungsergebnisse zeigen Verbindung zwischen suboptimaler Asthmaversorgung und Patienteneinstellungen in Europa auf 4Neue Forschungsergebnisse zeigen Verbindung zwischen suboptimaler Asthmaversorgung und Patienteneinstellungen in Europa auf 5Neue Forschungsergebnisse zeigen Verbindung zwischen suboptimaler Asthmaversorgung und Patienteneinstellungen in Europa auf 6Neue Forschungsergebnisse zeigen Verbindung zwischen suboptimaler Asthmaversorgung und Patienteneinstellungen in Europa auf 7Graphite Metallizing Now Offers GRAPHALLOY® Stainless Steel Pillow Blocks for Success in Submersible Applications 2Graphite Metallizing Now Offers GRAPHALLOY® Stainless Steel Pillow Blocks for Success in Submersible Applications 3Precision Positioning System Uses Miniaturezed Piezo Linear Motor: LPS-24 Linear Stage by PI 2Acne Cream, Probiotic Action Shares News on How Some Food may Breed Acne Causing Bacteria 2
... Oct. 15 /PRNewswire-Asia/ -- Sundia MediTech, a leading,pharmaceutical R&D ... D. Maher has been appointed Senior Vice President of ... Prior to joining Sundia, Mr. Maher was Executive Vice ... Group, a CRO company in,Florida, USA. Azopharma,s CRO ...
... ... pre-IND meeting with the U.S. Food and Drug Administration (FDA) regarding a ... Stemedica,s high potency proprietary allogeneic mesenchymal bone marrow-derived stem cells (adult human) ... 2009 with the FDA, Stemedica is planning to file an IND application ...
... The inaugural Advanced Bioenergy Conference and Expo, scheduled ... in Sacramento, Calif. will feature a number of internationally ... chain. , During the opening plenary session, Doug Cameron, ... & Co., will present The Investment Climate for ...
Cached Biology Technology:Sundia Appoints Charles D. Maher as Senior Vice President of Sales and Marketing 2Stemedica Completes Meeting with the FDA 2Stemedica Completes Meeting with the FDA 3Internationally Recognized Bioenergy Experts Convene in Sacramento 2
... An excellent ion chromatography system . ... twelve ranges from 0.01S to 5000S, houses the ... suppressor module CE 4715, is available. Data ... and software., Solvent delivery is by the high ...
... and other fluid sources for 4 vessels ... of each individual pump is controlled electronically. ... exactly maintained. ,High-precision controlled peristaltic pumps ... which allows flow rates between 0.01 to ...
... The loxP-amp-loxP cassette is designed ... The prokaryotic promoter gb2 driving the ... modified version of the Em7 promoter. It ... used Tn5 promoter. A synthetic polyadenylation signal ...
... the fast and simple integration of FRT-sites ... (for the generation of transgenic mouse models). ... allow neomycin / kanamycin selection in prokaryotic ... promoter (gb2) for expression of kanamycin resistance ...
Biology Products: