Navigation Links
Novel aptamer boosts T cell-based immune response to therapeutic vaccines
Date:1/23/2013

New Rochelle, NY, January 22, 2013A small compound called an aptamer that specifically targets and stimulates a human immune cell can greatly increase the effectiveness of an immunotherapeutic drug designed to destroy malignant or virus-infected cells. The development of a novel apatamer that recognizes activated T-lymphocytes and can boost the therapeutic effect of cell-based vaccines is described in an article in Nucleic Acid Therapeutics, a peer-reviewed journal from Mary Ann Liebert, Inc. publishers (http://www.liebertpub.com). The article is available on the Nucleic Acid Therapeutics website (http://www.liebertpub.com/nat).

Elizabeth Pratico, Bruce Sullenger, and Smita Nair, Duke University Medical Center, Durham, NC, describe the innovative techniques they used to create an aptamera short sequence of nucleic acidsthat binds to the human protein OX40, a costimulatory molecule present on the surface of already activated immune cells.

In the article "Identification and Characterization of an Agonistic Aptamer Against the T Cell Costimulatory Receptor, OX40," (http://online.liebertpub.com/doi/full/10.1089/nat.2012.0388) the researchers demonstrate that binding of the aptamer to OX40 on activated T cells enhances the cells' ability to proliferate and to produce the immunostimulatory cytokine interferon-gamma. The authors envision future studies that would evaluate the therapeutic potential of the human OX40 aptamer, which could be used to stimulate T cells during the production of patient-specific vaccines for use in cell therapy and personalized medicine.

"The therapeutic potential of aptamers has always been one of their most promising aspects," says Executive Editor Fintan Steele, PhD, SomaLogic, Inc., Boulder, CO. "This elegant work by the Duke team underlines that promise while extending it into the critical area of immunotherapy."


'/>"/>
Contact: Vicki Cohn
vcohn@liebertpub.com
914-740-2100 x2156
Mary Ann Liebert, Inc./Genetic Engineering News
Source:Eurekalert  

Related biology news :

1. Researchers discover novel therapy for Crohns disease
2. New clinical trial explores novel noninvasive colon cancer screening test
3. Notre Dame researchers using novel method to combat malaria drug resistance
4. Unique adaptations to a symbiotic lifestyle reveal novel targets for aphid insecticides
5. Key proteins newly discovered form and function may provide novel cancer treatment target
6. Novel discovery by NUS scientists paves the way for more effective treatment of cancers
7. London researchers discover novel mechanism involved in key immune response
8. Mexican rock heroes trial novel green trading system
9. VTT and GE Healthcare developing novel biomarkers to predict Alzheimers disease
10. Cleveland Clinic researchers receive $5 million grant to discover novel pathways to heart disease
11. Novel nano-structures to realize hydrogens energy potential
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Novel aptamer boosts T cell-based immune response to therapeutic vaccines
(Date:4/19/2017)... 19, 2017 The global military ... is marked by the presence of several large global ... by five major players - 3M Cogent, NEC Corporation, ... for nearly 61% of the global military biometric market ... the global military biometrics market boast global presence, which ...
(Date:4/13/2017)... PUNE, India , April 13, 2017 According ... Identity Proofing, Identity Authentication, Identity Analytics, Identity Administration, and Authorization), Service, Authentication ... by MarketsandMarkets™, the IAM Market is expected to grow from USD 14.30 ... Annual Growth Rate (CAGR) of 17.3%. ... ...
(Date:4/11/2017)... NXT-ID, Inc. (NASDAQ:   NXTD ) ... appointment of independent Directors Mr. Robin D. Richards ... Directors, furthering the company,s corporate governance and expertise. ... Gino Pereira , Chief Executive ... their guidance and benefiting from their considerable expertise as we ...
Breaking Biology News(10 mins):
(Date:6/15/2017)... (PRWEB) , ... June 15, 2017 , ... ... Saranas, a promising new medical device startup. Dan Parsley, angelMD’s SVP of Corporate ... angelMD members, and this angelMD syndicate is part of Saranas’ recently announced $4 ...
(Date:6/14/2017)... (PRWEB) , ... June 14, 2017 , ... ... bushing materials for pumps and process equipment, has appointed Andrew Ondish as Territory ... , Ondish holds a B.S. degree in Petroleum Engineering from Colorado School of ...
(Date:6/14/2017)... (PRWEB) , ... June 14, ... ... the completion of its Phase 1 clinical study of AC0058, a novel ... treatment of B cell-related autoimmune diseases, including rheumatoid arthritis and systemic lupus ...
(Date:6/13/2017)... and London UK (PRWEB) , ... June 13, 2017 , ... ... Information and Study on Clinical Trial Participation (CISCRP) and the Society for Clinical Research ... speakers will provide background on the purpose of eConsent and the ability for eConsent ...
Breaking Biology Technology: