Navigation Links
Novel antibody prevents infection by hepatitis C virus
Date:5/5/2009

Boston, Mass. Taking aim at a leading cause of liver failure in the United States, a team of scientists at the Massachusetts Biologic Laboratories (MBL) of the University of Massachusetts Medical School (UMMS) has developed a human monoclonal antibody that neutralizes the Hepatitis C virus (HCV). The new antibody effectively neutralized the virus in culture, and then prevented infection by the virus in a pre-clinical animal model of the disease.

Details of the research were presented April 23 in Copenhagen, Denmark at the 44th Annual Meeting of the European Association for the Study of the Liver (EASL). "We are pleased with the progress of this program," said Donna Ambrosino, MD, executive director of the MBL and a professor of pediatrics at the Medical School. "This antibody shows significant efficacy against the virus."

In the current study, MBL scientists injected transgenic mice (HuMAb Mouse technology, Medarex, Inc.) with elements of HCV and then painstakingly searched for individual human antibodies produced in the mice that would recognize and bind to the HCV's outer coat, known as the glycoprotein. Once they found human antibodies that looked promising, they evaluated in vitro the ability of those antibodies to neutralize the virus and selected a lead candidate antibody for further characterization. Collaborative work with clinical researchers from the Department of Medicine at the Medical School's Worcester campus demonstrated that this antibody, now known as MBL-HCV1, was able to bind tightly with all genotypes of HCV tested from infected patient samples.

MBL-HCV1 was then tested off-site on three non-human primates. In that study, one animal received no antibody, one a low dose of the new antibody, and one a higher dose. Then all three animals were exposed to HCV. The animals with low or no antibody dosages developed HCV infections, but the animal with the higher dose was protected. Subsequently, researchers gave the
'/>"/>

Contact: Michael Cohen
michael.cohen@umassmed.edu
508-868-4778
University of Massachusetts Medical School
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. MGH researchers describe new way to identify, evolve novel enzymes
2. Muscle mass: Scientists identify novel mode of transcriptional regulation during myogenesis
3. Novel 3-D cell culture model shows selective tumor uptake of nanoparticles
4. IdentiPHI Re Launches SAFmodule Software to Secure Novell(R) Networks
5. IdentiPHI Re Launches SAFmodule Software to Secure Novell(R) Networks
6. 454 Sequencing: Science paper describes a novel, highly efficient method of sequencing ancient DNA
7. Scientists discover novel way to remove iron from ferritin
8. Identification of a novel class of (not-so) small RNAs
9. A novel way found to prevent protein plaques implicated in Alzheimers
10. Sirtris unveils promising, novel SIRT1 activators for treating diseases of aging
11. Feinstein researchers develop new genetic method and identify novel genes for schizophrenia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/4/2015)... 2015 Research and Markets ( ... "Global Biometrics Market Forecast and Opportunities, 2020" ... market for biometric authentication systems is projected to ... 2020 The driving forces for this ... government projects and constant development in technology. In ...
(Date:3/2/2015)...  Businesses have a new option for premier ... Enterprises has announced the launch of a brand ... businesses to protect their customers, personal data, as ... Beconux is a biometric transaction processing system recently ... an ATM machine, the new system fuses multiple ...
(Date:2/24/2015)... , Feb. 24, 2015 This report analyzes the ... provides separate comprehensive analytics for the US, Canada ... , Asia-Pacific , Middle ... Annual estimates and forecasts are provided for the period 2013 ... these markets. Market data and analytics are derived from primary ...
Breaking Biology News(10 mins):Global Biometrics Market Forecast and Opportunities, 2020 2Global Biometrics Market Forecast and Opportunities, 2020 3Personal Data Protection Company Launches New Product 2World Iris Biometrics Industry 2World Iris Biometrics Industry 3World Iris Biometrics Industry 4World Iris Biometrics Industry 5World Iris Biometrics Industry 6World Iris Biometrics Industry 7World Iris Biometrics Industry 8World Iris Biometrics Industry 9World Iris Biometrics Industry 10World Iris Biometrics Industry 11
... May 26, 2011 A family of naturally occurring ... associated with Alzheimer,s disease, according to a new study ... alkaloids could potentially be used in therapeutic drugs to ... effects of Alzheimer,s, according to the study published recently ...
... PITTSBURGHNature is just outside your door in your ... of trees down the block. During the week of this ... to create gigapixel imagery of this natural environment as part ... trio of biologists and their partners at Carnegie Mellon University,s ...
... Researchers (and some cat-owners) wanted to know: What do feral ... A two-year study offers a first look at ... territories overlap on the urban, suburban, rural and agricultural edges ... a sophisticated activity-tracking device to capture the haunts and habits ...
Cached Biology News:TGen study identifies compounds that could slow down Alzheimer's disease 2GigaBlitz will turn high-resolution images of nature into global inventory of organisms, habitats 2Researchers track the secret lives of feral and free-roaming house cats 2Researchers track the secret lives of feral and free-roaming house cats 3Researchers track the secret lives of feral and free-roaming house cats 4
(Date:3/4/2015)... 4, 2015 /CNW/ - Resverlogix Corp. (TSX:RVX) (the ... a collaborative research program with Emerald Logic, ... Collective Evolution Technology (FACET), Emerald Logic analyzed ... obtained from each of 798 patients who ... trials ASSERT, SUSTAIN and ASSURE. The objective ...
(Date:3/4/2015)... 2015 AcelRx Pharmaceuticals, Inc. (Nasdaq: ... on the development and commercialization of innovative therapies ... today announced that it will release fourth quarter ... on Monday, March 9th, 2015. AcelRx management will ... Eastern Time (1:30 p.m. Pacific Time) on March ...
(Date:3/4/2015)... Jose, California (PRWEB) March 04, 2015 ... Reaction (PCR) represents one of the fastest growing technologies ... cell biologists in subcellular visualization is driving growth in ... need for deeper understanding of gene expressions will continue ... market. Expanding applications in fields ranging from pharma, biotech, ...
(Date:3/4/2015)... Massachusetts , March 4, 2015 ... präsentiert innovative Entwicklungen für Diagnostik und Therapie, Strahlendosismanagement ...   Royal Philips (NYSE: ... Europäischen Röntgenkongress 2015 (ECR) bekannt, der ... stattfindet. An den Ständen Nr. 102 ...
Breaking Biology Technology:Resverlogix Collaborates with Emerald Logic to Identify Factors Driving Drug Response and Efficacy in Phase 2 Program 2Resverlogix Collaborates with Emerald Logic to Identify Factors Driving Drug Response and Efficacy in Phase 2 Program 3Resverlogix Collaborates with Emerald Logic to Identify Factors Driving Drug Response and Efficacy in Phase 2 Program 4AcelRx Pharmaceuticals to Hold Annual 2014 Financial Results Conference Call and Webcast on Monday, March 9th, 2015 2AcelRx Pharmaceuticals to Hold Annual 2014 Financial Results Conference Call and Webcast on Monday, March 9th, 2015 3Focus on Quantifying Nucleic Acid Molecules Spurs Growth in the qPCR & dPCR Instrumentation Market, According to a New Report by Global Industry Analysts, Inc. 2Focus on Quantifying Nucleic Acid Molecules Spurs Growth in the qPCR & dPCR Instrumentation Market, According to a New Report by Global Industry Analysts, Inc. 3Focus on Quantifying Nucleic Acid Molecules Spurs Growth in the qPCR & dPCR Instrumentation Market, According to a New Report by Global Industry Analysts, Inc. 4Philips stellt integrierte Bildgebungslösungen auf dem Europäischen Röntgenkongress 2015 vor 2Philips stellt integrierte Bildgebungslösungen auf dem Europäischen Röntgenkongress 2015 vor 3Philips stellt integrierte Bildgebungslösungen auf dem Europäischen Röntgenkongress 2015 vor 4Philips stellt integrierte Bildgebungslösungen auf dem Europäischen Röntgenkongress 2015 vor 5Philips stellt integrierte Bildgebungslösungen auf dem Europäischen Röntgenkongress 2015 vor 6
... SAN MATEO, Calif., May 11, 2011 Nile ... that develops novel therapeutics for heart failure patients, today announced ... Capital Market effective with the open of business on May ... trading under the "NLTX" symbol on the OTCQB Marketplace following ...
... 2011 Palatin Technologies, Inc. (NYSE Amex: ... dysfunction indications and PL-3994 for acute asthma and other ... Cranbury, N.J.  Four proposals were submitted to, and approved ... authorized common stock, from 40,000,000 shares to 100,000,000 shares. ...
... JERICHO, N.Y., May 11, 2011 HCCS ... provider of online healthcare compliance and competency training ... an enhanced version of COI-SMART , a ... of Conflict of Interest disclosures. HCCS built this ...
Cached Biology Technology:Nile Therapeutics to Transition to OTCQB Marketplace 2Nile Therapeutics to Transition to OTCQB Marketplace 3Palatin Technologies, Inc. Announces Results of Annual Stockholders' Meeting 2Conflict of Interest Disclosures Tool Updated 2
Includes a choice of any 3 EasySep mouse selection kits and EasySep magnet...
... trypsinizing flasks are used for ... cell suspensions by digestion of ... accepts cotton plugs. Four extra-deep ... Height of Baffles mm ...
... Application: For the efficient enrichment of ... tissue or cell culture. The isolated ... degradation and metabolic pathway analysis. Metabolic ... deficiency in children, cystic fibrosis and ...
Plasmid expressing PLAP reporter gene....
Biology Products: