Navigation Links
Novel NIST connector uses magnets for leak-free microfluidic devices
Date:11/18/2009

Like other users of microfluidic systems, National Institute of Standards and Technology (NIST) researcher Javier Atencia was faced with an annoying engineering problem: how to simply, reliably and most of all, tightly, connect his tiny devices to the external pumps and reservoirs delivering liquids into the system. While pondering this one day, he randomly picked up two magnets and began playing with them. As the magnets pulled apart and then snapped back together, Atencia realized that he had his solution.

In a paper recently published online in Lab on a Chip,* Atencia and colleagues describe the result of that brainstorm: a new, inexpensive, reusable and highly efficient microfluidic connector. The NIST connector employs a ring magnet with a O-ring gasket on its bottom and a tube in its center set directly atop the inlet or outlet port of a microfluidic channel embedded in a glass chip. A disc magnet on the underside of the chip holds the first magnetand its tubingsecurely in place.

Unlike traditional approaches to connectorssuch as gluing the tubing directly to the chip or mounting a male/female connection with the tubing attached to the male portionthe NIST magnetic connector is reusable; can be positioned anywhere on the chip; and eliminates any possibility of broken bonds that leak, chips cracked during heat curing of the glue, or microfluidic devices turned useless by excess glue entering the channels. Additionally, the reliability, flexibility and fast assembly of the NIST connector compares favorably to a recently developed press-fit system (where springs produce the sealing force) but the magnetic connectors cost hundreds of dollars less to build and operate.

As reported in their paper, the NIST researchers demonstrated the viability of their magnetic connector in a microfluidic device designed to generate liposomes (tiny bubble-shaped membranes that can be used to transport drugs throughout the body), a fairly port-intensive task. A solution of lipids suspended in isopropyl alcohol is pumped at a high rate into a microchannel through one inlet and hit with a buffer solution pumped in through four other ports. The convection and diffusion that occurs as the liquid streams mix produces liposomes that exit the microfluidic device through an outlet port. Magnetic connectors at the five inlets and one outlet were removed and reseated numerous times without any visible leakage.

The NIST researchers state that their magnetic connector is suitable for most microfluidic applications except those dealing with iron-containing (ferro) fluids, superparamagnetic particles (particles so small that their magnetic properties decrease with time and fluctuations in temperature), cells tagged with magnetic particles, or high-temperatures (greater than 80 degrees Celsius).


'/>"/>

Contact: Michael E. Newman
michael.newman@nist.gov
301-975-3025
National Institute of Standards and Technology (NIST)
Source:Eurekalert  

Related biology news :

1. UD start-up company prepares to commercialize novel detector for medical, military applications
2. TAXIS Pharmaceuticals licenses novel antimicrobial technology from Rutgers and UMDNJ
3. Novel on-off switch mechanism stops cancer in its tracks
4. University of Miami receives NIH grant to support novel technology for tissue engineering
5. Novel bacterial strains clear algal toxins from drinking water
6. Novel genetic region identified for childhood asthma in Mexicans
7. Novel polymer could improve protein-based drugs
8. Novel mechanism revealed for increasing recombinant protein yield in tobacco
9. La Jolla Institute discovers novel tumor suppressor
10. Got zinc? New zinc research suggests novel therapeutic targets
11. Funxional successfully completes initial clinical trial of FX125L, an anti-inflammatory drug with a novel mechanism of action
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Novel NIST connector uses magnets for leak-free microfluidic devices
(Date:6/21/2016)... 21, 2016 NuData Security announced today that ... of principal product architect and that Jon ... customer development. Both will report directly to ... moves reflect NuData,s strategic growth in its product ... customer demand and customer focus values. ...
(Date:6/9/2016)... Paris Police Prefecture and ... ensure the safety of people and operations in several locations ... Teleste, an international technology group specialised in broadband ... its video security solution will be utilised by ... across the country. The system roll-out is scheduled for the ...
(Date:6/2/2016)... Perimeter Surveillance & Detection Systems, Biometrics & ... & Other Service  The latest report from ... of the global Border Security market . Visiongain ... billion in 2016. Now: In November 2015 ... and hardware technologies for advanced video surveillance. ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... June 23, 2016 , ... UAS ... the launch of their brand, UP4™ Probiotics, into Target stores nationwide. The company, ... proud to add Target to its list of well-respected retailers. This list includes ...
(Date:6/23/2016)... 23, 2016 /PRNewswire/ - FACIT has announced the ... biotechnology company, Propellon Therapeutics Inc. ("Propellon" or ... of a portfolio of first-in-class WDR5 inhibitors for ... as WDR5 represent an exciting class of therapies, ... medicine for cancer patients. Substantial advances have been ...
(Date:6/23/2016)... , June 23, 2016 Houston ... with the Cy-Fair Sports Association to serve as ... the agreement, Houston Methodist Willowbrook will provide sponsorship ... and connectivity with association coaches, volunteers, athletes and ... with the Cy-Fair Sports Association and to bring ...
(Date:6/23/2016)... , June 23, 2016  The Prostate Cancer Foundation (PCF) ... precise treatments and faster cures for prostate cancer. Members of the Class of ... 15 countries. Read More About the Class of 2016 ... ... ...
Breaking Biology Technology: