Novel 3-D cell culture model shows selective tumor uptake of nan... (ices from newborn rats can be cultured f...)

Novel 3-D cell culture model shows selective tumor uptake of nanoparticles

Date:8/22/2007

ices from newborn rats can be cultured for weeks and are an important tool in brain biology. In the cell co-culture model now reported, these two techniques have been brought together for the first time. Brain tumor cell aggregates were labeled with fluorescent iron microparticles and grown on normal newborn rat-brain tissue slices. The double cell labeling technique allowed investigation of tumor cell invasion into brain tissue by either fluorescence or electron microscopy from the same samples. Using these techniques the tumor aggregates were found to invade the brain slices in a similar manner to tumors in the body. Having developed the model then the tumor selective uptake of nanoparticles was demonstrated in the co-culture.

The collaboration on this project has been nurtured by Professor David Walker of the School of Human Development who co-founded the Childrens Brain Tumor Research Group at Nottingham. Understanding the biology of tumors is important if we are to develop effective new treatments said Professor Walker. This work demonstrates how close co-operation between disciplines can help to push forward ideas which could lead to new clinical therapies.

Dr. Steven R. Goodman, Editor-in-Chief of Experimental Biology and Medicine, agrees with Professor Walker. Dr. Goodman stated The convergence of cancer cell biology and nanoscience, exemplified by this study, holds great promise for the future of brain tumor therapy. Experimental Biology and Medicine is a journal dedicated to the publication of multidisciplinary and interdisciplinary research in the biomedical sciences.

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Contact: Dr. Martin Garnett
martin.garnett@nottingham.ac.uk
44-011-595-15045
Society for Experimental Biology and Medicine
Source:Eurekalert

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Novel 3-D cell culture model shows selective tumor uptake of nan...(ices from newborn rats can be cultured f...)