Navigation Links
Novartis and collaborators discover novel antimalarial drug candidate
Date:9/2/2010

Singapore, September 3, 2010 Novartis announced today that scientists at the Novartis Institute for Tropical Diseases (NITD), in collaboration with researchers from the Genomics Institute of the Novartis Research Foundation (GNF), the Swiss Tropical and Public Health Institute and The Scripps Research Institute have discovered a novel compound that shows promise as a next generation treatment for drug resistant malaria. Major support for the project was provided by the Wellcome Trust, the Medicines for Malaria Venture (MMV), A*STAR, Singapore and the U.S. government.

Published this week in Science the findings demonstrate that the antimalarial candidate, spiroindolone NITD609, is effective against both strains of the malaria parasite, Plasmodium (P.) falciparum and P. vivax. Through a novel mechanism NITD609 rapidly clears plasmodium in a malaria mouse model and shows pharmacological properties compatible with a once-daily dosing regimen. Copies of the embargoed Science paper are available at scipak@aaas.org.

According to the World Health Organization (WHO), in 2008 there were approximately 247 million cases of malaria, causing nearly one million deaths, mostly among young children in Africa. Although malaria is preventable and curable, it is estimated that in Africa, a child dies every 45 seconds from the disease.1

"Malaria remains a scourge," said Mark Fishman, president, Novartis Institutes for BioMedical Research. "The parasite has demonstrated a frustrating ability to outwit new medicines, from quinine to today's unsettling increased tolerance to artemisinin derivatives. We are delighted that our scientists could provide this potential new malaria therapy, based on an unprecedented chemical structure and directed to a novel target."

Further regulatory pharmacological and safety evaluation is currently ongoing and, provided the outcome of these studies is
'/>"/>

Contact: Mariellen Gallagher
mariellen.gallagher@novartis.com
001-617-871-7665
Novartis Institutes for BioMedical Research
Source:Eurekalert

0

GOOD

Page: 1 2 3

Related biology news :

1. Novartis awards 2010 Prizes for Immunology in recognition of outstanding contributions to immunology in medical research
2. Clemson and collaborators receive $1.1 million to improve durability of concrete infrastructure
3. K-State researcher, collaborators study virulence of pandemic H1N1 virus
4. Formula discovered for longer plant life
5. Chemical equator discovery will aid pollution mapping
6. Researchers discover that growing up too fast may mean dying young in honey bees
7. Scientists discover why a mothers high-fat diet contributes to obesity in her children
8. Sirtris review of sirtuin therapeutics for diseases of aging in Nature Reviews Drug Discovery
9. Groundbreaking discovery may lead to stronger antibiotics
10. Discovery of natural compounds that could slow blood vessel growth
11. Earliest animal footprints ever found -- discovered in Nevada
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/19/2013)... paper published in the journal Polar Biology, researchers report using ... may be a new type of killer whale ( Orcinus ... unusual-looking killer whales stranded on a New Zealand beach and ... were also taken but it was almost 50 years before ... small white eye-patch and bulbous forehead, was documented alive in ...
(Date:6/19/2013)... DETROIT Insulin is the most potent physiological ... the storage and synthesis of lipids, protein and ... the circulatory system. It also plays a major ... where the glucose is metabolized and removed from ... understanding the precise molecular mechanisms by which insulin ...
(Date:6/19/2013)... floods across the Midwest are expected to contribute to ... Mexico "dead zone," according to a University of Michigan ... along with one for the Chesapeake Bay. , The ... Oceanic and Atmospheric Administration, calls for an oxygen-depleted, or ... which would place it among the 10 largest on ...
Breaking Biology News(10 mins):Breakthrough research of essential molecule reveals important targets in diabetes and obesity 2U-M researcher and colleagues predict possible record-setting Gulf of Mexico 'dead zone' 2U-M researcher and colleagues predict possible record-setting Gulf of Mexico 'dead zone' 3U-M researcher and colleagues predict possible record-setting Gulf of Mexico 'dead zone' 4
... does to an alpine ibex. , According to ... demonstrate a correlation between horn growth and genetic diversity. ... correlates with a greater chance of survival. ... genetic quality of the ibex—and the bigger, the better," ...
... the Abramson Family Cancer Research Institute of the University of ... development leads to premature aging and loss of stem cell ... the body’s response to damaged DNA, and mutations in proteins ... and other disorders in humans. This work appears in the ...
... ovarian tissue, blood vessels, even whole organs available when ... directly comparing slow-freezing techniques, used successfully for decades to ... of cryopreservation that transforms tissues into durable glass-like structures. ... Medical College of Georgia are comparing the two approaches ...
Cached Biology News:Bigger horns equal better genes 2Loss of stem cells correlates with premature aging in animal study 2Studies to find better ways to preserve human eggs, ovarian tissue under way 2Studies to find better ways to preserve human eggs, ovarian tissue under way 3Studies to find better ways to preserve human eggs, ovarian tissue under way 4Studies to find better ways to preserve human eggs, ovarian tissue under way 5
(Date:6/19/2013)... June 19, 2013 India’s vast ... can potentially be worth up to a billion ... the Indian government is taking serious action to ... process. , This presentation will examine:, ... ,     Immediate and long term impacts , ...
(Date:6/18/2013)... Clara, CA (PRWEB) June 18, 2013 ... to standard size SEMs but have limited performance and ... lower resolution. Full size SEMs would normally provide better ... more knowledge to operate and have a higher cost ... address the gap between these two types of ...
(Date:6/18/2013)... MD, USA (PRWEB) June 18, 2013 ... announced the opening of two new offices in Asia—one ... in Singapore will serve as RAPS’ Pan-Asia office ... office will be more focused on audiences within China. ... RAPS announced its partnership with five Singapore government agencies ...
(Date:6/18/2013)... , June 18, 2013 RegeneCure ... the company,s  proprietary AMCA Guided Bone Regeneration (GBR) Dental Membrane ... A common problem encountered when patients have a ... sufficient bone volume to house the implant. Consequently there is ... substitute until the natural bone regenerates. The bone substitute material, ...
Breaking Biology Technology:Nanounity Introduces the Pemtron Range of Compact Scanning Electron Microscopes 2Nanounity Introduces the Pemtron Range of Compact Scanning Electron Microscopes 3RAPS Opens Offices in Singapore and China 2RAPS Opens Offices in Singapore and China 3RegeneCure Starts Clinical Study Using Polymeric Bone Stimulating Membrane for Dental Implants 2RegeneCure Starts Clinical Study Using Polymeric Bone Stimulating Membrane for Dental Implants 3
... Medicine , Susan Huang and colleagues describe the use ... by integrating two freely available software packages, to identify ... data from patients admitted to a 750-bed academic medical ... authors found that the tool identified a number of ...
... ... a US report on Fermenters market. The US market for fermenters is projected to reach ... demand for biological drugs worldwide, and growing use of disposable or single-use fermenters. , ... San Jose, California (PRWEB) February 22, ...
... special ink infused with nanoparticles, Stanford engineer Yi Cui ... lightweight paper batteries and supercapacitors (which, like batteries, store ... well as stretchable, conductive textiles known as "eTextiles" ... of ordinary paper or fabric. While the technology ...
Cached Biology Technology:Tool identifies infection clusters; rate of T cell drop not helpful in decision to start treating HIV 2Tool identifies infection clusters; rate of T cell drop not helpful in decision to start treating HIV 3Tool identifies infection clusters; rate of T cell drop not helpful in decision to start treating HIV 4US Fermenters Market to Reach $180 million by 2015, According to New Report by Global Industry Analysts, Inc. 2US Fermenters Market to Reach $180 million by 2015, According to New Report by Global Industry Analysts, Inc. 3Nanotechnology sparks energy storage on paper and cloth 2Nanotechnology sparks energy storage on paper and cloth 3
Applications: ISH...
...
... Synthetic peptide derived from the N-terminal ... dog and orangutang occludin proteins. ... protein. Reactivity: Human (positive controls: ... rat mouse dog and orangutang is ...
...
Biology Products: