Navigation Links
Nottingham researchers lead world's largest study into pre-eclampsia
Date:5/16/2012

Researchers from The University of Nottingham are leading the largest ever international research project into the genetics of the potentially fatal condition pre-eclampsia.

The research will aim to provide new insights into the prevention, prediction and treatment of the disease, which kills up to 40,000 women and almost one million babies every year worldwide.

As part of the study, DNA collected from thousands of pregnant women, including many from Nottingham, will be studied in an attempt to find genetic clues which may predict which women are more at risk of developing the illness.

Dr Linda Morgan, associate professor in The University of Nottingham's School of Molecular Medical Sciences, said: "We are studying the genes which lead women to develop pre-eclampsia. By understanding which genes cause the disease, it may be possible to prevent pre-eclampsia or improve treatment."

Pre-eclampsia affects around 5% of pregnancies, developing in the second half of pregnancy, often without warning signs, and is detected when the mother is found to have high blood pressure and protein in her urine.

If left untreated, it can have devastating consequences for both mother and child and in the most serious cases can be fatal. It is associated with small babies and premature births and in the mother can lead to convulsions, bleeding and damage to the liver.

Nottingham is co-ordinating the InterPregGen (International Pregnancy Genetics) study, which also involves obstetricians, midwives and geneticists from Finland, Iceland, Kazakhstan, Norway, Uzbekistan and the universities of Leeds and Glasgow, the London School of Hygiene and Tropical Medicine and the Wellcome Trust Sanger Institute in the UK.

Funded with a 6m grant from the European Union, the project will run for four-and-a-half years and will aim to develop our understanding of the genetic link which scientists believe plays a major role in pre-eclampsia.

The condition runs in families a woman whose mother or sister has had pre-eclampsia is at least three times more likely to develop the disease. As babies inherit genes from both parents the study will be looking at the genetic makeup of mother, father and child.

Once the researchers find a gene that is connected with pre-eclampsia, they can identify in detail what that particular gene does and find out when it is active during pregnancy. The academics will then be able to decide whether it is at work in the mother, baby or the placenta. When they understand the genetic mechanisms influencing the condition, they will be in a better position to prevent and treat it.

It will also help to identify women who are at the highest risk of developing the condition during their pregnancy, so that additional ante-natal care can be provided for them.

As part of the international study, researchers will be undertaking whole genome sequencing of people from Central Asia for the first time, in a similar way to the 1,000 Genomes project, which will also provide long-term biological information for future research in these populations.


'/>"/>

Contact: Emma Thorne
emma.thorne@nottingham.ac.uk
44-115-951-5793
University of Nottingham
Source:Eurekalert

Related biology news :

1. Transportation fuels of the future: Nottingham leads the way
2. International prize for Nottingham spine research
3. Nottinghamshire Police First Law Enforcement Agency to Deploy ForensicSoft in United Kingdom
4. 2010 Julian Cole Lectureship awarded to John King, University of Nottingham
5. Microbiology brought to life in Nottingham
6. Nottingham success in green technologies awards
7. Nottingham researchers help bridge the urban and rural divide in the UK and India
8. Nottingham scientists reveal genetic wiring of seeds
9. NC State researchers get to root of parasite genome
10. Researchers find animal with ability to survive climate change
11. Researchers find an essential gene for forming ears of corn
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/20/2016)... MINNEAPOLIS , May 20, 2016  VoiceIt ... technology partnership with VoicePass. By working ... user experience.  Because VoiceIt and VoicePass take slightly ... two engines increases both security and usability. ... expressed excitement about this new partnership. ...
(Date:5/9/2016)... , UAE, May 9, 2016 ... when it comes to expanding freedom for high net ... Even in today,s globally connected world, there is ... conferencing system could ever duplicate sealing your deal with ... obtaining second passports by taking advantage of citizenship via ...
(Date:4/28/2016)... , April 28, 2016 First quarter 2016: ... up 966% compared with the first quarter of 2015 ... SEK 589.1 M (loss: 18.8) and the operating margin was 40% ... 0.32) Cash flow from operations was SEK 249.9 M ... revenue guidance is unchanged, SEK 7,000-8,500 M. The operating ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... 27, 2016 , ... Rolf K. Hoffmann, former senior vice ... University of North Carolina Kenan-Flagler Business School effective June 27. , ... with a focus on the school’s international efforts, leading classes and participating in ...
(Date:6/24/2016)... , June 24, 2016  Regular discussions on a ... take place between the two entities said Poloz. ... Ottawa , he pointed to the country,s ... the federal government. ... said, "Both institutions have common economic goals, why not sit ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Researchers at ... most commonly-identified miRNAs in people with peritoneal or pleural mesothelioma. Their findings are the ... read it now. , Diagnostic biomarkers are signposts in the blood, lung fluid ...
(Date:6/23/2016)... , June 23, 2016   Boston ... of novel compounds designed to target cancer stemness ... has been granted Orphan Drug Designation from the ... treatment of gastric cancer, including gastroesophageal junction (GEJ) ... inhibitor designed to inhibit cancer stemness pathways by ...
Breaking Biology Technology: