Navigation Links
Notre Dame study focuses on protein dynamics
Date:1/21/2010

A discovery by associate professor of chemistry and biochemistry Brian Baker and his research group at the University of Notre Dame reveals the importance of dynamic motion by proteins involved in the body's immune response. Results of the study were published in Immunity, the leading research journal in the field of immunology.

Scientists have long known that receptors on the immune system's T-cells are important for discovering and destroying cells that are infected with viruses or other pathogens. Baker's group studied cross-reactivity, the ability of different T-cell receptors which number perhaps a few hundred million in the body to recognize the vastly larger number of possible antigens produced by other cells. The process is important for dealing with viruses, cancers, autoimmunity, transplant rejection and other issues related to the immune system.

Most past studies considered the receptors on each cell as static components, but in fact the molecules move and adopt multiple structures. Baker's group found that the success or failure of the T-cell receptor to attach to a target cell's antigen involves complex movements in search of a compatible final structure. Different antigens produce different kinds of motion.

"What we're adding to the equation is how motion is involved," Baker said. "It both complicates as well as simplifies how we think about recognition. Different extents of motion can exist when you have different antigens being presented. It complicates our thinking about how diversity is presented to the immune system, yet simplifies our thinking about how diversity is accommodated by the immune system.

"Overall, we've got to consider flexibility when we think about structures in the immune system and structures in biology in general."

The static view long-favored in structural biology is shifting to a greater emphasis on protein dynamics, he says. For example, scientists have discovered that vaccines can help the immune system fight cancer, but vaccines that mimic biological structures can still fail if they do not take into account flexibility and dynamics.

"It probably will be one of the defining areas of biochemistry over the next 10 to 15 years getting at the role of how biological molecules move and how that movement influences biology," Baker said.


'/>"/>

Contact: brian baker
briann-baker@nd.edu
574-631-4311
University of Notre Dame
Source:Eurekalert

Related biology news :

1. Notre Dame researchers describe new tool for evaluating managed relocations
2. Childhood obesity indicates greater risk of school absenteeism, Penn study reveals
3. A study by the MUHC and McGill University opens a new door to understanding cancer
4. Study begins to reveal clues to the cause and progression of sepsis
5. Clones on task serve greater good, evolutionary study shows
6. New study warns limited carbon market puts 20 percent of tropical forest at risk
7. New study examines how rearing environment can alter navigation
8. Study links cat disease to flame retardants in furniture and to pet food
9. New continent and species discovered in Atlantic study
10. Study shows link between alcohol consumption and hiv disease progression
11. Feeling hot, hot, hot: New study suggests ways to control fever-induced seizures
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/16/2017)... , May 16, 2017   Bridge ... health organizations, and MD EMR Systems , ... development partner for GE, have established a partnership ... Portal product and the GE Centricity™ products, including ... EMR. These new integrations will ...
(Date:4/24/2017)... 24, 2017 Janice Kephart , ... Identity Strategy Partners, LLP (IdSP) , today issues ... President Trump,s March 6, 2017 Executive Order: ... vetting can be instilled with greater confidence, enabling ... all refugee applications are suspended by until at ...
(Date:4/18/2017)... 2017  Socionext Inc., a global expert in SoC-based imaging and ... the M820, which features the company,s hybrid codec technology. A demonstration ... Probe, Inc., will be showcased during the upcoming Medtec Japan at ... the Las Vegas Convention Center April 24-27. ... Click here for an ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... AMRI, a global contract ... to improve patient outcomes and quality of life, will now be offering its ... attributed to new regulatory requirements for all new drug products, including the finalization ...
(Date:10/11/2017)... Charlotte, N.C. (PRWEB) , ... October 11, 2017 ... ... ARCS® Foundation President Andi Purple announced Dr. Suneel I. Sheikh, the ... Laboratories ( ASTER Labs ), Inc. has been selected for membership in ...
(Date:10/11/2017)... ... ... a basic first aid supply for any work environment, but most personal eye wash can ... a dangerous substance enters both eyes? It’s one less decision, and likely quicker response time ... , “Whether its dirt and debris, or an acid or alkali, getting anything in your ...
(Date:10/11/2017)... , ... October 11, 2017 , ... ... announced today it will be hosting a Webinar titled, “Pathology is going digital. ... Associates , on digital pathology adoption best practices and how Proscia improves lab ...
Breaking Biology Technology: