Navigation Links
Notre Dame study focuses on protein dynamics
Date:1/21/2010

A discovery by associate professor of chemistry and biochemistry Brian Baker and his research group at the University of Notre Dame reveals the importance of dynamic motion by proteins involved in the body's immune response. Results of the study were published in Immunity, the leading research journal in the field of immunology.

Scientists have long known that receptors on the immune system's T-cells are important for discovering and destroying cells that are infected with viruses or other pathogens. Baker's group studied cross-reactivity, the ability of different T-cell receptors which number perhaps a few hundred million in the body to recognize the vastly larger number of possible antigens produced by other cells. The process is important for dealing with viruses, cancers, autoimmunity, transplant rejection and other issues related to the immune system.

Most past studies considered the receptors on each cell as static components, but in fact the molecules move and adopt multiple structures. Baker's group found that the success or failure of the T-cell receptor to attach to a target cell's antigen involves complex movements in search of a compatible final structure. Different antigens produce different kinds of motion.

"What we're adding to the equation is how motion is involved," Baker said. "It both complicates as well as simplifies how we think about recognition. Different extents of motion can exist when you have different antigens being presented. It complicates our thinking about how diversity is presented to the immune system, yet simplifies our thinking about how diversity is accommodated by the immune system.

"Overall, we've got to consider flexibility when we think about structures in the immune system and structures in biology in general."

The static view long-favored in structural biology is shifting to a greater emphasis on protein dynamics, he says. For example, scientists have discovered that
'/>"/>

Contact: brian baker
briann-baker@nd.edu
574-631-4311
University of Notre Dame
Source:Eurekalert

Page: 1 2

Related biology news :

1. Notre Dame researchers describe new tool for evaluating managed relocations
2. Childhood obesity indicates greater risk of school absenteeism, Penn study reveals
3. A study by the MUHC and McGill University opens a new door to understanding cancer
4. Study begins to reveal clues to the cause and progression of sepsis
5. Clones on task serve greater good, evolutionary study shows
6. New study warns limited carbon market puts 20 percent of tropical forest at risk
7. New study examines how rearing environment can alter navigation
8. Study links cat disease to flame retardants in furniture and to pet food
9. New continent and species discovered in Atlantic study
10. Study shows link between alcohol consumption and hiv disease progression
11. Feeling hot, hot, hot: New study suggests ways to control fever-induced seizures
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/16/2014)... such as buying clothing not made in a sweat ... their own bags when they go shopping? According to ... Research , ethical consumption is motivated by a need ... into action. , "Advocates of ethical consumerism suggest that ... the products they choose, but unfortunately only a small ...
(Date:9/16/2014)... Sept. 16, 2014  Cross Match Technologies, a ... announced today the launch of its Verifier ® ... identity of an individual using their secure credentials ... rapidly reads credential documents with embedded biometric data ... the biometric to a live scan of their ...
(Date:9/15/2014)... (September 15, 2014) The so-called central dogma ... proteinhas long provided a simplified explanation for how ... organisms. , In reality, of course, the ... first articulated nearly 60 years ago by Nobel ... structure. For one, there are multiple types of ...
Breaking Biology News(10 mins):Why are consumers willing to spend more money on ethical products? 2Cross Match Launches New Identity Management Handheld Solution 2Scientists discover RNA modifications in some unexpected places 2
... discovery by UNC scientists describes how cells infected by ... called exosomes, changing their cellular "cargo" of proteins and ... the growth of recipient cells from benign to cancer-producing. ... effects and potentially manipulate other cells throughout the body. ...
... University of California, San Diego School of Medicine and ... approved drugs to more than 1,000 proteins in Mycobacterium ... avenues to repurpose these drugs to treat TB. ... Computational Biology . "Tuberculosis is currently one of ...
... study by researchers at the Johns Hopkins Bloomberg School of ... disease among male clients of the commercial sex industry in ... drug use as the primary transmission mode of all HIV ... of publication in the journal Sexually Transmitted Infections . ...
Cached Biology News:UNC scientists identify cellular communicators for cancer virus 2TB-drugome provides new targets for anti-tuberculosis drug discovery 2Study examines risk of heterosexual HIV transmission in China 2
(Date:9/17/2014)... 17, 2014 The Pistoia Alliance, ... lowering the barriers to innovation in life sciences ... of Carmen Nitsche as Executive Director Business Development ... its global reach. , Carmen joins the Pistoia ... Corporate Development. At Accelrys, she managed various life ...
(Date:9/16/2014)... This report analyzes the worldwide markets for Bioinformatics ... and Biocontent. The report provides separate comprehensive analytics for the ... , Europe , Asia-Pacific ... World. Annual estimates and forecasts are provided for the period ... for these markets. Market data and analytics are derived from ...
(Date:9/16/2014)... D.C., September 16, 2014 --The emerging field of ... to the next level, enabling the construction of ... efficient devices, individual molecules would take on the ... transistors. , A team of researchers from five ... candidate for use in small-scale electronics: a molecule ...
(Date:9/16/2014)... BlueInGreen® , a water quality company offering ... gases into liquids, announced the addition of ... firm to its sales network. H2Flow will promote ... wastewater applications in the Canadian provinces of Ontario ... and serves Quebec and Ontario markets for water, ...
Breaking Biology Technology:Pistoia Alliance Expands Business Development with Appointment of Carmen Nitsche 2Global Bioinformatics Industry 2Global Bioinformatics Industry 3Global Bioinformatics Industry 4Global Bioinformatics Industry 5Global Bioinformatics Industry 6Global Bioinformatics Industry 7Global Bioinformatics Industry 8Global Bioinformatics Industry 9Global Bioinformatics Industry 10Global Bioinformatics Industry 11Global Bioinformatics Industry 12Global Bioinformatics Industry 13Global Bioinformatics Industry 14Global Bioinformatics Industry 15Global Bioinformatics Industry 16Global Bioinformatics Industry 17Global Bioinformatics Industry 18Global Bioinformatics Industry 19Global Bioinformatics Industry 20Global Bioinformatics Industry 21Global Bioinformatics Industry 22Global Bioinformatics Industry 23The future face of molecular electronics 2BlueInGreen® Expands into Canada – Signs Representative Agreement with H2Flow Equipment Inc. 2
... engine dedicated to recruiting exceptional talent to jobs at ... the most rewarding careers on the planet, but they ... StartUpHire website, www.startuphire.com , lists thousands of jobs ... investor, and more. Search agents allow users to ...
... (Pink Sheets: SYNJ), Reports that it has engaged in ... The job of the Director will be to coordinate ... Pinnacle Energy Division. The Company is currently considering ventures ... production, and microwave plasma physics. To that end, the ...
... NOVATO, Calif., March 18 BioMarin Pharmaceutical Inc. (Nasdaq: ... for clinical trial authorization (CTA) for BMN 110 or ... lysosomal storage disorder Mucopolysaccharidosis Type IVA (MPS IVA), or ... Kingdom Medicines and Healthcare Products Regulatory Agency (MHRA). BioMarin ...
Cached Biology Technology:StartUpHire Launches Comprehensive Search Engine for Jobs at Venture-Backed Companies 2StartUpHire Launches Comprehensive Search Engine for Jobs at Venture-Backed Companies 3Syndication Inc. Seeks 'DIRECTOR OF TECHNICAL ENGINEERING' for 'PINNACLE ENERGY' - Its New Alternative Energy Subsidiary 2BioMarin's Clinical Trial Application for GALNS for Morquio A Syndrome Accepted by the MHRA 2BioMarin's Clinical Trial Application for GALNS for Morquio A Syndrome Accepted by the MHRA 3BioMarin's Clinical Trial Application for GALNS for Morquio A Syndrome Accepted by the MHRA 4