Navigation Links
Notre Dame researchers report progress on compound to treat neurological diseases
Date:10/7/2011

Results of a study by a group of University of Notre Dame researchers represent a promising step on the road to developing new drugs for a variety of neurological diseases.

The group from the University's Departments of Chemistry and Biochemistry and Biological Sciences and the Friemann Life Sciences Center focused on the design, synthesis and evaluation of water-soluble "gelatinase inhibitor" compounds.

Gelatinases, a class of enzymes, have been implicated in a host of human diseases from cancer to cardiovascular conditions and in particular neurological conditions such as stroke, aneurysm and traumatic brain injury. Researchers have increasingly focused on developing potent gelatinase inhibitor drugs to treat acute gelatinase-dependent diseases.

The Notre Dame group has been investigating variants of a compound called "SB-3CT," which shows promise as a selective and potent gelatinase inhibitor. SB-3CT has exhibited potent efficacy in animal models for a variety of neurological and cancer diseases.

The preferred method of treatment for acute gelatinase-dependent diseases is intravenous infusion. Intravenous administration requires that the compound be water soluble. Unfortunately SB-3CT has poor water solubility and poor drug-like properties..

In a new approach, the Notre Dame researchers used a prodrug strategy to address this issue. A prodrug is an inactive precursor of a drug that is converted into its active form in the body by normal metabolic processes.

The prodrug strategy produced a greater than 5,000-fold increase in water solubility compared to SB-3CT. In addition to its high water solubility, the prodrug (referred to as ND-478) was chemically stable, non-toxic and was quickly converted to the active drug in the blood.. These favorable properties of ND-478 make it suitable for intravenous administration in the treatment of acute gelatinase-dependent diseases. Such a compound offers the possibility of translation into the
'/>"/>

Contact: Mayland Chang
mchang@nd.edu
574-631-2965
University of Notre Dame
Source:Eurekalert

Page: 1 2

Related biology news :

1. Notre Dame researchers demonstrate antibiotic sensing event central to MSRA antibiotic resistance
2. Notre Dame research reveals brain network connections
3. Breakthrough in Niemann-Pick Type C research reported by Notre Dame and Cornell scientists
4. Notre Dame research offers important clues about grasshopper population explosions
5. Notre Dame biologists call for regulation of rare plant sales
6. Notre Dame researcher helps discover walking properties of bacteria
7. Notre Dame and Wyoming scientists genetically engineer silkworms to produce artificial spider silk
8. Twins are intriguing research subjects for Notre Dame biometircs researchers
9. Notre Dame study focuses on protein dynamics
10. Notre Dame researchers describe new tool for evaluating managed relocations
11. UNH researchers: Multibeam sonar can map undersea gas seeps
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/23/2014)... culinary herbs oregano and rosemary are packed with healthful ... in much the same way as prescription anti-diabetic medication, ... Journal of Agricultural and Food Chemistry , they ... difference, and they also identified which compounds contribute the ... Mejia and colleagues point out that in 2012, type-2 ...
(Date:7/23/2014)... degradation and blood-brain barrier damage appear after ... functioning. Matrix metalloproteinase-9 is able to degrade ... around cerebral blood vessels and to mediate ... and colleagues from the First Affiliated Hospital ... China induced cerebral infarction in stroke-prone spontaneously ...
(Date:7/23/2014)... the brain is important for encoding environment ... mechanisms are unclear. Dr. Zhouyan Feng and ... activity of hippocampal neurons in rats using ... the neuronal responses. Somatosensory stimulation, in the ... potentials into theta rhythm-dominated waveforms, decreased the ...
Breaking Biology News(10 mins):
... biologists at Rutgers, Waksman Institute of Microbiology are ... an unassuming name. Now they have convinced the ... tremendous potential for cleaning up pollution, combating global ... builds upon Rutgers, burgeoning energy and environmental research ...
... in Spanish . , Barcelona, Spain: Research ... women undergo assisted reproduction technology (ART) shows that for younger ... two attempts, whereas women over the age of 40 had ... throughout their first four attempts. Mr Simon Hong ...
... available in Spanish . , Barcelona, Spain: ... into an egg to fertilise it, is increasingly used to ... the procedure may appear quite normal, researchers in the US ... damage, which can decrease the chances of pregnancy. Mr. ...
Cached Biology News:Duckweed genome sequencing has global implications 2Failure of the 1st attempt at assisted reproduction justifies at least 1 additional cycle 2Failure of the 1st attempt at assisted reproduction justifies at least 1 additional cycle 3Normal-looking sperm may have serious damage; scientists urge more care in selection 2Normal-looking sperm may have serious damage; scientists urge more care in selection 3
(Date:7/23/2014)... Israel , July 23, 2014 ... a portfolio company of Trendlines Agtech , ... of Israel,s leading agricultural ... , Valentis,s technology combines nanocrystalline cellulose ... pulp waste, with additional nanoparticles to produce highly ...
(Date:7/23/2014)... 2014 Shire plc (LSE: ... specialty biopharmaceutical company, and ArmaGen, a US privately ... and collaboration agreement for AGT-182, an investigational enzyme ... both the central nervous system (CNS) and somatic ... This collaboration strengthens Shire,s rare disease pipeline of ...
(Date:7/23/2014)... California (PRWEB) July 23, 2014 With the ... in HD resolution for more than 15 minutes, Fastec Imaging ... the world of high speed imaging. “Finally, a high speed ... camera we use in our everyday lives.” proclaims Matt Kearney, ... Fastec has always been to demystify and simplify the traditionally ...
(Date:7/23/2014)... 2014 Astra Nova Training ... consultancy and pharma training services, and the ... , a non-profit integrating the expertise and investments ... a global system for clinical trials, are pleased ... the expertise of industry professionals through improved and ...
Breaking Biology Technology:Valentis Nanotech Signs MOU to Integrate Technology in Thermoplastics Production 2Shire Enters Strategic Licensing and Collaboration Agreement With ArmaGen 2Shire Enters Strategic Licensing and Collaboration Agreement With ArmaGen 3Shire Enters Strategic Licensing and Collaboration Agreement With ArmaGen 4Shire Enters Strategic Licensing and Collaboration Agreement With ArmaGen 5Fastec Imaging Introduces the First High Speed Camcorder 2Fastec Imaging Introduces the First High Speed Camcorder 3Astra Nova and ACRES Partner on Quality and Access of Training for Research Professionals 2Astra Nova and ACRES Partner on Quality and Access of Training for Research Professionals 3
... the Molecular Bioassays Market , , MOUNTAIN ... recent analysis of the molecular bioassays market, Frost ... Frost & Sullivan North America Technology Innovation of ... for cell surface receptor investigation, in particular G ...
... Case Studies and Patient Reported Outcome Strategies , ... the industry leader in electronic patient reported outcomes (ePRO) ... its 2009 ePROficiency(TM) Web seminar series on Patient Reported ... series is a continuation of invivodata,s educational initiative which ...
... MAO-B at Maximum Approved Dose , , KANSAS ... presented results from a clinical pharmacology study in which ... tyramine sensitivity at the maximum approved dose of 1 ... Congress of Parkinson,s Disease and Movement Disorders in Paris, ...
Cached Biology Technology:Frost & Sullivan Recognizes Cisbio Bioassays for Technology Innovation 2Frost & Sullivan Recognizes Cisbio Bioassays for Technology Innovation 3Frost & Sullivan Recognizes Cisbio Bioassays for Technology Innovation 4Frost & Sullivan Recognizes Cisbio Bioassays for Technology Innovation 5invivodata Announces ePROficiency 2009 Web Seminar Series 2Clinical Pharmacology Study With AZILECT(R) (Rasagiline Tablets) Demonstrated It Does Not Increase Tyramine Sensitivity 2Clinical Pharmacology Study With AZILECT(R) (Rasagiline Tablets) Demonstrated It Does Not Increase Tyramine Sensitivity 3Clinical Pharmacology Study With AZILECT(R) (Rasagiline Tablets) Demonstrated It Does Not Increase Tyramine Sensitivity 4Clinical Pharmacology Study With AZILECT(R) (Rasagiline Tablets) Demonstrated It Does Not Increase Tyramine Sensitivity 5
... dispensers save space and organize gloves, ... garb. They are the perfect benchtop ... in labs, processing and manufacturing. Clear ... the particles they attract. Many other ...
... for genome-wide microRNA expression profiling and ... Paraflo microfluidic on-chip synthesis platform. These ... our comprehensive microRNA Expression Profiling Service. ... Rice microRNA Microarray contains all known ...
... research-grade spectrofluorometer with a minimum 1 nm ... 200 or greater for the Raman band ... to keep in mind in order to ... titration, or anisotropic measurements. ,The FP-6500 is ...
... microRNA expression profiling and built on ... on-chip synthesis platform. These microarrays are ... microRNA Expression Profiling Service. ... Microarray contains all known fish microRNAs ...
Biology Products: