The research is a culmination of prior studies that Serianni's research group has conducted on saccharide degradation and rearrangement. In 1982, his group discovered the first stereospecific C1-C2 transposition reaction of saccharides, catalyzed by molybdate ion, that resulted in a process called C2 epimerization. This work led to new and convenient synthetic pathways for the 13C-labeling of saccharides upon which a commercial business as founded.
Serianni's lab has also promoted the use of 13C and other isotopes as tools to investigate new chemical and biochemical reactions, to probe biological metabolism, and to develop new clinical and diagnostic tools and tests.
"In this sense, the glucosone work fits nicely into our overall research mission," Serianni said.
The glucosone research was described in a study that appeared in the Journal of the American Chemical Society and was supported by the National Institute of Diabetes and Digestive and Kidney Disease.
|Contact: Anthony S. Serianni|
University of Notre Dame