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Notre Dame paper sheds light on genetic and physiological basis for metabolic diseases
Date:9/23/2013

behavioral and physiological evidence supporting a role for Id2 in the function of glucose homeostasis and circadian control of feeding and locomotor activity.

The researchers also established a circadian and metabolic phenotype that is defined by sex and age.

"We observed profound changes in their feeding behavior," Duffield said. "This is interesting since the timing and 24-hour pattern of feeding in mice and in humans is thought to contribute to the development of obesity and metabolic disease. These knockout mice are lean, and are highly sensitive to the hormone insulin, and especially interesting is that the insulin sensitivity property is only found in the male animals. These sex-specific aspects of glucose metabolism add yet another layer of complexity on the genetic basis for developing metabolic disorders."

Some of the research involved imaging of metabolic activity in living mice using positron emission tomography, where they could pinpoint very precisely where in fact the changes in physiology are occurring (see also related press release 'Notre Dame-Bruker partnership promotes advancements in imaging' http://news.nd.edu/news/41308-notre-dame-bruker-partnership-promotes-advancements-in-molecular-imaging/). The researchers discovered higher levels of glucose taken up by skeletal muscle and brown adipose tissue, but again only in the male knockout mice.

"Brown adipose tissue, once thought to be absent in adult humans but in fact recently shown to occur in a proportion of women and men, generates body heat from metabolizing nutrients, such as sugars and fats," Duffield said. "Because it can divert nutrients to heat synthesis, rather than fat storage, and under the right conditions white adipose tissue can actually be converted to brown-type adipose tissue (also known as beige fat), it has been proposed tha
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Contact: Giles Duffield
Duffield.2@nd.edu
574-631-1834
University of Notre Dame
Source:Eurekalert

Page: 1 2 3 4

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