Navigation Links
Notre Dame paper sheds light on genetic and physiological basis for metabolic diseases
Date:9/23/2013

behavioral and physiological evidence supporting a role for Id2 in the function of glucose homeostasis and circadian control of feeding and locomotor activity.

The researchers also established a circadian and metabolic phenotype that is defined by sex and age.

"We observed profound changes in their feeding behavior," Duffield said. "This is interesting since the timing and 24-hour pattern of feeding in mice and in humans is thought to contribute to the development of obesity and metabolic disease. These knockout mice are lean, and are highly sensitive to the hormone insulin, and especially interesting is that the insulin sensitivity property is only found in the male animals. These sex-specific aspects of glucose metabolism add yet another layer of complexity on the genetic basis for developing metabolic disorders."

Some of the research involved imaging of metabolic activity in living mice using positron emission tomography, where they could pinpoint very precisely where in fact the changes in physiology are occurring (see also related press release 'Notre Dame-Bruker partnership promotes advancements in imaging' http://news.nd.edu/news/41308-notre-dame-bruker-partnership-promotes-advancements-in-molecular-imaging/). The researchers discovered higher levels of glucose taken up by skeletal muscle and brown adipose tissue, but again only in the male knockout mice.

"Brown adipose tissue, once thought to be absent in adult humans but in fact recently shown to occur in a proportion of women and men, generates body heat from metabolizing nutrients, such as sugars and fats," Duffield said. "Because it can divert nutrients to heat synthesis, rather than fat storage, and under the right conditions white adipose tissue can actually be converted to brown-type adipose tissue (also known as beige fat), it has been proposed tha
'/>"/>

Contact: Giles Duffield
Duffield.2@nd.edu
574-631-1834
University of Notre Dame
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Notre Dame researchers develop system that uses a big data approach to personalized healthcare
2. Notre Dame study finds Asian carp DNA not widespread in the Great Lakes
3. Notre Dame researcher is studying role small dams play in pollution control
4. Notre Dame researchers are using new technologies to combat invasive species
5. Notre Dame research may have important implications for combating diabetes
6. Cargill expands support of Notre Dame Haiti Program
7. Notre Dame research reveals migrating Great Lakes salmon carry contaminants upstream
8. Notre Dame research could improve sustainability and cost effectiveness of wastewater treatment
9. Notre Dame research could provide new insights into tuberculosis and other diseases
10. Notre Dame researcher is shedding light on how jaws evolve
11. Notre Dame establishes professorships in adult stem cell research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... people are too stressed they are often grouchy, grumpy, ... Institute (BMI) at EPFL have just highlighted a fundamental ... and the loss of social skills and cognitive impairment. ... regulatory molecule in the brain. This was revealed by ... , Carmen Sandi,s team went to look for answers ...
(Date:9/18/2014)... the ideal animal in which to study the genes ... into tens of thousands of freshwater streams and lakes ... adapt to the new environment. , Breeding studies between ... up one of the genes that controls tooth number, ... regulation in a freshwater population is associated with a ...
(Date:9/18/2014)... invisible is probably the ultimate form of camouflage: you ... And this strategy is not as uncommon as you ... Baltimore County, USA, explains that the larval life stages ... one part of the anatomy that most creatures cannot ... eyes have to shield each individual eye unit with ...
Breaking Biology News(10 mins):How stress tears us apart 2Counting fish teeth reveals regulatory DNA changes behind rapid evolution, adaptation 2Counting fish teeth reveals regulatory DNA changes behind rapid evolution, adaptation 3Transparent larvae hide opaque eyes behind reflections 2
... five times as likely as U.S-born children to suffer from ... Health Department study, and the risk is highest among the ... lead poisoning in 2002, published online in the American Journal ... lived abroad within the previous six months were 11 times ...
... WASHINGTON, DECEMBER 19, 2007 - The National Fish ... grant to the Manomet Center for Conservation Sciences ... programs that address the decline of shorebird populations ... will be conducted by the Western Hemisphere Shorebird ...
... rattlesnake skin and smear it on their fur to ... study by researchers at UC Davis. Barbara Clucas, ... observed ground squirrels (Spermophilus beecheyi) and rock squirrels (Spermophilus ... pieces of shed snakeskin, chewing it and then licking ...
Cached Biology News:Study shows immigrant children are at increased risk of lead poisoning 2Study shows immigrant children are at increased risk of lead poisoning 3Manomet Center awarded major NFWF grant to foster shorebird conservation 2Manomet Center awarded major NFWF grant to foster shorebird conservation 3
(Date:9/18/2014)... the ultimate memory device for computing may have just ... College of New York led by chemist Stephen O,Brien ... and ferroelectric properties. , Combining both properties is very ... them and for the devices that might ultimately be ... properties in a single material, however, has proved difficult ...
(Date:9/17/2014)... -- PDL BioPharma, Inc. (PDL) (NASDAQ: PDLI ) was ... Young LLP ("EY") that it was resigning effective September 11, ... the Company on September 15, 2014 and reported in PDL,s ... PDL has issued the following statement in response to the ... on the reason for the resignation of EY.  We were ...
(Date:9/17/2014)... DIEGO and PRINCETON, N.J. ... (NASDAQ: OTCQB:AEMD), the pioneer in developing targeted therapeutic devices ... and its diagnostic subsidiary, Exosome Sciences, Inc. (ESI), disclosed ... 2014 Exosomes & SingleCell Analysis Summit. On ... Exosome Sciences will give a presentation entitled: "Exosomes: A ...
(Date:9/17/2014)... NEWTOWN, Pa. , Sept. 17, 2014 ... services and eClinical Solutions, today announced three of its ... Conference for Clinical Data Management to be held ... Vegas, Nevada . The Company also announced the ... to raise overall quality in clinical trials acquired earlier ...
Breaking Biology Technology:Oxides discovered by CCNY team could advance memory devices 2PDL BioPharma Issues Statement on Resignation of Ernst and Young as Corporate Auditors 2PDL BioPharma Issues Statement on Resignation of Ernst and Young as Corporate Auditors 3Aethlon Medical and Exosome Sciences To Present at the Exosomes & SingleCell Analysis Summit 2Aethlon Medical and Exosome Sciences To Present at the Exosomes & SingleCell Analysis Summit 3BioClinica to Present at 20th Annual SCDM Conference 2BioClinica to Present at 20th Annual SCDM Conference 3
... broad corporate changes are ... ... Board: AVNA) today reported financial results for its first,quarter ended March ... Company refocused its business model from managing the,development of a portfolio ...
... Technology Distributors ... 2007., PLEASANTON, Calif., May 19 Direct Medical ... distribution network covering all,of Russia. This partnership has resulted ... volume sales to a number of medical,providers in Russia., ...
... W. Freston Single Topic Conference Series for ... Gastroenterology ... (AGA) Foundation for Digestive Health and Nutrition (FDHN),announced a gift ... Fund within the AGA Foundation,s overall endowment.,Interest earned from The ...
Cached Biology Technology:Advance Nanotech Reports First Quarter 2008 Financial Results 2Advance Nanotech Reports First Quarter 2008 Financial Results 3Advance Nanotech Reports First Quarter 2008 Financial Results 4Advance Nanotech Reports First Quarter 2008 Financial Results 5Advance Nanotech Reports First Quarter 2008 Financial Results 6Advance Nanotech Reports First Quarter 2008 Financial Results 7Advance Nanotech Reports First Quarter 2008 Financial Results 8Advance Nanotech Reports First Quarter 2008 Financial Results 9Advance Nanotech Reports First Quarter 2008 Financial Results 10Direct Medical Systems Reaches Profitability in 2-1/2 Years, as a Result of Sales of the World's Smallest and Lightest Ultrasound System, the InNovaSound USB Ultrasound. 2Takeda Pharmaceuticals Establishes $3 Million Endowment with AGA Foundation 2Takeda Pharmaceuticals Establishes $3 Million Endowment with AGA Foundation 3Takeda Pharmaceuticals Establishes $3 Million Endowment with AGA Foundation 4
Request Info...
... Bean Nuclease catalyzes the degradation of single-stranded ... terminated products. While the nuclease prefers ssDNA ... concentrations the enzyme degrades double-stranded DNA from ... been used for transcript mapping studies (3,4), ...
... fosmid (40kb), and large plasmid insert (10-20kb) ... BAC vector. On command 20-50 fold copy ... DNA purification. Available with blue-white screening (pEZ ... the highest insert stability. Kits include electrocompetent ...
...
Biology Products: