Navigation Links
Notre Dame chemists discover new class of antibiotics
Date:3/7/2014

A team of University of Notre Dame researchers led by Mayland Chang and Shahriar Mobashery have discovered a new class of antibiotics to fight bacteria such as methicillin-resistant Staphylococcus aureus (MRSA) and other drug-resistant bacteria that threaten public health. Their research is published in the Journal of the American Chemical Society in an article titled "Discovery of a New Class of Non-beta-lactam Inhibitors of Penicillin-Binding Proteins with Gram-Positive Antibacterial Activity."

The new class, called oxadiazoles, was discovered in silico (by computer) screening and has shown promise in the treatment of MRSA in mouse models of infection. Researchers who screened 1.2 million compounds found that the oxadiazole inhibits a penicillin-binding protein, PBP2a, and the biosynthesis of the cell wall that enables MRSA to resist other drugs. The oxadiazoles are also effective when taken orally. This is an important feature as there is only one marketed antibiotic for MRSA that can be taken orally.

MRSA has become a global public-health problem since the 1960s because of its resistance to antibiotics. In the United States alone, 278,000 people are hospitalized and 19,000 die each year from infections caused by MRSA. Only three drugs currently are effective treatments, and resistance to each of those drugs already exists.

The researchers have been seeking a solution to MRSA for years. "Professor Mobashery has been working on the mechanisms of resistance in MRSA for a very long time," Chang said. "As we understand what the mechanisms are, we can devise strategies to develop compounds against MRSA."

"Mayland Chang and Shahriar Mobashery's discovery of a class of compounds that combat drug resistant bacteria such as MRSA could save thousands of lives around the world. We are grateful for their leadership and persistence in fighting drug resistance," said Greg Crawford, dean of the College of Science at the University of Notre Dame.


'/>"/>
Contact: Mayland Chang
mchang@nd.edu
574-631-2965
University of Notre Dame
Source:Eurekalert

Related biology news :

1. Notre Dame paper sheds light on genetic and physiological basis for metabolic diseases
2. Notre Dame researchers develop system that uses a big data approach to personalized healthcare
3. Notre Dame study finds Asian carp DNA not widespread in the Great Lakes
4. Notre Dame researcher is studying role small dams play in pollution control
5. Notre Dame researchers are using new technologies to combat invasive species
6. Notre Dame research may have important implications for combating diabetes
7. Cargill expands support of Notre Dame Haiti Program
8. Notre Dame research reveals migrating Great Lakes salmon carry contaminants upstream
9. Notre Dame research could improve sustainability and cost effectiveness of wastewater treatment
10. Notre Dame research could provide new insights into tuberculosis and other diseases
11. Notre Dame researcher is shedding light on how jaws evolve
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/11/2017)... PALM BEACH GARDENS, Fla. , April 11, ... biometric identity management and secure authentication solutions, today ... million contract by Intelligence Advanced Research Projects Activity ... technologies for IARPA,s Thor program. "Innovation ... the onset and IARPA,s Thor program will allow ...
(Date:4/5/2017)... , April 5, 2017  The Allen Institute ... Allen Cell Explorer: a one-of-a-kind portal and dynamic digital ... 3D imaging data, the first application of deep learning ... human stem cell lines and a growing suite of ... platform for these and future publicly available resources created ...
(Date:3/30/2017)... -- On April 6-7, 2017, Sequencing.com will host the world,s ... at Microsoft,s headquarters in Redmond, Washington ... health and wellness apps that provide a unique, personalized ... is the first hackathon for personal genomics and the ... the genomics, tech and health industries are sending teams ...
Breaking Biology News(10 mins):
(Date:9/14/2017)... ... September 14, 2017 , ... Cambridge Semantics ... today announced that its Anzo Smart Data Lake has been named a ... and solutions that help organizations succeed in surpassing their knowledge management goals. KMWorld ...
(Date:9/12/2017)... ... September 12, 2017 , ... ... of their latest product LabCODE™, a novel Lab Information Management System (LIMS) ... capabilities for Biobanking, Pharmacokinetics, Pharmacogenetics, Next Generation Sequencing, Flow Cytometry, Pathology, and ...
(Date:9/12/2017)... Wayne, PA (PRWEB) , ... September 12, 2017 , ... ... and growing life sciences teams, today announced that Tobias Massa, PhD has joined the ... pharmaceuticals, biotech, life sciences, and technology to his Board position. Most recently he served ...
(Date:9/12/2017)... Philadelphia PA and London UK (PRWEB) , ... ... ... company, continues to strengthen its position as the clinical technology provider for small ... unified clinical trial suite. , Sponsors unfamiliar with DrugDev Spark can experience solutions ...
Breaking Biology Technology: