Navigation Links
Notre Dame chemists discover new class of antibiotics
Date:3/7/2014

A team of University of Notre Dame researchers led by Mayland Chang and Shahriar Mobashery have discovered a new class of antibiotics to fight bacteria such as methicillin-resistant Staphylococcus aureus (MRSA) and other drug-resistant bacteria that threaten public health. Their research is published in the Journal of the American Chemical Society in an article titled "Discovery of a New Class of Non-beta-lactam Inhibitors of Penicillin-Binding Proteins with Gram-Positive Antibacterial Activity."

The new class, called oxadiazoles, was discovered in silico (by computer) screening and has shown promise in the treatment of MRSA in mouse models of infection. Researchers who screened 1.2 million compounds found that the oxadiazole inhibits a penicillin-binding protein, PBP2a, and the biosynthesis of the cell wall that enables MRSA to resist other drugs. The oxadiazoles are also effective when taken orally. This is an important feature as there is only one marketed antibiotic for MRSA that can be taken orally.

MRSA has become a global public-health problem since the 1960s because of its resistance to antibiotics. In the United States alone, 278,000 people are hospitalized and 19,000 die each year from infections caused by MRSA. Only three drugs currently are effective treatments, and resistance to each of those drugs already exists.

The researchers have been seeking a solution to MRSA for years. "Professor Mobashery has been working on the mechanisms of resistance in MRSA for a very long time," Chang said. "As we understand what the mechanisms are, we can devise strategies to develop compounds against MRSA."

"Mayland Chang and Shahriar Mobashery's discovery of a class of compounds that combat drug resistant bacteria such as MRSA could save thousands of lives around the world. We are grateful for their leadership and persistence in fighting drug resistance," said Greg Crawford, dean of the College of Science at the University of Notre Dame.


'/>"/>
Contact: Mayland Chang
mchang@nd.edu
574-631-2965
University of Notre Dame
Source:Eurekalert

Related biology news :

1. Notre Dame paper sheds light on genetic and physiological basis for metabolic diseases
2. Notre Dame researchers develop system that uses a big data approach to personalized healthcare
3. Notre Dame study finds Asian carp DNA not widespread in the Great Lakes
4. Notre Dame researcher is studying role small dams play in pollution control
5. Notre Dame researchers are using new technologies to combat invasive species
6. Notre Dame research may have important implications for combating diabetes
7. Cargill expands support of Notre Dame Haiti Program
8. Notre Dame research reveals migrating Great Lakes salmon carry contaminants upstream
9. Notre Dame research could improve sustainability and cost effectiveness of wastewater treatment
10. Notre Dame research could provide new insights into tuberculosis and other diseases
11. Notre Dame researcher is shedding light on how jaws evolve
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/11/2017)... , Apr. 11, 2017 Research and ... Market 2017-2021" report to their offering. ... The global eye tracking market to grow at a ... report, Global Eye Tracking Market 2017-2021, has been prepared based on ... covers the market landscape and its growth prospects over the coming ...
(Date:4/5/2017)... April 5, 2017 Today HYPR Corp. ... the server component of the HYPR platform is officially ... the end-to-end security architecture that empowers biometric authentication across ... has already secured over 15 million users across the ... of connected home product suites and physical access represent ...
(Date:3/30/2017)... , March 30, 2017 The research team ... for three-dimensional (3D) fingerprint identification by adopting ground breaking 3D fingerprint ... new realm of speed and accuracy for use in identification, crime ... affordable cost. ... A ...
Breaking Biology News(10 mins):
(Date:5/24/2017)... ... May 24, 2017 , ... Today, the ... Water Recovery’s Advanced Biological Nutrient Recovery (ABNR™) technology at its 4,000,000 gallon per ... plant upgrade to sustainably meet current and future nutrient discharge regulations. The ABNR ...
(Date:5/24/2017)... 23, 2017 As Ebola resurfaces in the ... and 20 suspected cases now reported, a new analysis of ... showed a correlation between the 2014 and 2017 outbreaks of ... sharply in 2012-13, which preceded the 2014 outbreak. An analysis ... gene Replikin counts in 2014-15, which again precedes the current ...
(Date:5/23/2017)... (PRWEB) , ... May 23, 2017 , ... ... celebrates this month its 20th anniversary, marking the occasion with a strong presence ... the meeting’s Welcome Reception and further extends an invitation to all attendees to ...
(Date:5/23/2017)... ... May 23, 2017 , ... ... applications, has announced a facility expansion to accommodate its rapid growth. , The ... new workspace and renovation of the existing areas. The expansion includes, a state-of-the-art ...
Breaking Biology Technology: