Navigation Links
Notre Dame chemists discover new class of antibiotics
Date:3/7/2014

A team of University of Notre Dame researchers led by Mayland Chang and Shahriar Mobashery have discovered a new class of antibiotics to fight bacteria such as methicillin-resistant Staphylococcus aureus (MRSA) and other drug-resistant bacteria that threaten public health. Their research is published in the Journal of the American Chemical Society in an article titled "Discovery of a New Class of Non-beta-lactam Inhibitors of Penicillin-Binding Proteins with Gram-Positive Antibacterial Activity."

The new class, called oxadiazoles, was discovered in silico (by computer) screening and has shown promise in the treatment of MRSA in mouse models of infection. Researchers who screened 1.2 million compounds found that the oxadiazole inhibits a penicillin-binding protein, PBP2a, and the biosynthesis of the cell wall that enables MRSA to resist other drugs. The oxadiazoles are also effective when taken orally. This is an important feature as there is only one marketed antibiotic for MRSA that can be taken orally.

MRSA has become a global public-health problem since the 1960s because of its resistance to antibiotics. In the United States alone, 278,000 people are hospitalized and 19,000 die each year from infections caused by MRSA. Only three drugs currently are effective treatments, and resistance to each of those drugs already exists.

The researchers have been seeking a solution to MRSA for years. "Professor Mobashery has been working on the mechanisms of resistance in MRSA for a very long time," Chang said. "As we understand what the mechanisms are, we can devise strategies to develop compounds against MRSA."

"Mayland Chang and Shahriar Mobashery's discovery of a class of compounds that combat drug resistant bacteria such as MRSA could save thousands of lives around the world. We are grateful for their leadership and persistence in fighting drug resistance," said Greg Crawford, dean of the College of Science at the University of Notre Dame.


'/>"/>
Contact: Mayland Chang
mchang@nd.edu
574-631-2965
University of Notre Dame
Source:Eurekalert

Related biology news :

1. Notre Dame paper sheds light on genetic and physiological basis for metabolic diseases
2. Notre Dame researchers develop system that uses a big data approach to personalized healthcare
3. Notre Dame study finds Asian carp DNA not widespread in the Great Lakes
4. Notre Dame researcher is studying role small dams play in pollution control
5. Notre Dame researchers are using new technologies to combat invasive species
6. Notre Dame research may have important implications for combating diabetes
7. Cargill expands support of Notre Dame Haiti Program
8. Notre Dame research reveals migrating Great Lakes salmon carry contaminants upstream
9. Notre Dame research could improve sustainability and cost effectiveness of wastewater treatment
10. Notre Dame research could provide new insights into tuberculosis and other diseases
11. Notre Dame researcher is shedding light on how jaws evolve
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/18/2016)... --> --> Competitive Landscape ... Vehicles, Physical infrastructure and Perimeter Surveillance & Detection Systems ... market and the continuing migration crisis in the ... has led visiongain to publish this unique report, which is ... & security companies in the border security market and ...
(Date:3/15/2016)... March 15, 2016 --> ... by Transparency Market Research "Digital Door Lock Systems Market - ... - 2023," the global digital door lock systems market in ... 2014 and is forecast to grow at a CAGR of ... small and medium enterprises (MSMEs) across the world and high ...
(Date:3/14/2016)... NXTD ) ("NXT-ID" or the "Company"), a company ... of a new series of commercials on Time Warner Cable ... .  The commercials will air on Bloomberg TV, Fox Business ... show. --> NXTD ) ("NXT-ID" or the "Company"), ... the airing of a new series of commercials on Time ...
Breaking Biology News(10 mins):
(Date:4/28/2016)... ... April 28, 2016 , ... Morris Midwest ( ... for regional manufacturers at its Maple Grove, Minnesota technical center, May 11-12. ... and Trumpf. Almost 20 leading suppliers of tooling, accessories, software and other ...
(Date:4/27/2016)... ... 27, 2016 , ... Shimadzu Scientific Instruments (SSI) will be ... Business Conference and Expo. Shimadzu’s high-performance instruments enable laboratories to test cannabis products ... can stop by booth 1021 to learn how Shimadzu’s instruments can help improve ...
(Date:4/27/2016)... (PRWEB) , ... April 27, 2016 , ... ... Touch screen mobile devices with fingerprint recognition for secure access, voice recognition ... only a few ways consumers are interacting with biometrics technology today. But ...
(Date:4/27/2016)... SILVER SPRING, Md. and RESEARCH ... -- United Therapeutics Corporation (NASDAQ: UTHR ) announced ... Co-Chief Executive Officer, of United Therapeutics will provide an ... Deutsche Bank 41 st Annual Health Care Conference. ... May 5, 2016, at 10:00 a.m. Eastern Time, and ...
Breaking Biology Technology: