Navigation Links
Not quite 'roid rage
Date:9/29/2011

Fruit fly aggression is correlated with smaller brain parts, involves complex interactions between networks of important genes, and often cannot be controlled with mood-altering drugs like lithium.

Those are the results of a painstaking study conducted by researchers at North Carolina State University and colleagues in Belgium who are trying to discover what happens in the genes and brains of hyper-aggressive flies and how that differs from what takes place in more passive fly cousins.

Dr. Trudy Mackay, William Neal Reynolds Distinguished University Professor of Genetics and a co-lead author of a paper published this week in Proceedings of the National Academy of Sciences, says that the findings in the fruit fly could one day lead to helping humans think of Alzheimer's patients who suddenly become more aggressive by providing a framework of how complex gene interactions affect behavior. Fruit flies are model organisms for studying genes and traits like aggression.

In the study, the researchers showed that making changes, or mutations, to a handful of genes made some passive flies aggressive and made some aggressive flies really aggressive. They also showed the effects of mating flies with different mutations to see which mutant combinations had larger effects on aggression.

The researchers also showed that certain portions of the fly brain the so-called mushroom bodies, which affect locomotion, experience and memory were smaller in the hyper-aggressive flies.

The study also showed that calming did not necessarily come through chemistry, as doses of lithium soothed some but not all of the aggressive flies. These mixed results were also evident when flies were given two other types of calming drugs.

"This study shows that these brain networks are not simple, and that you can't look at just one gene at a time," says study co-author Dr. Robert Anholt, William Neal Reynolds Professor of Biology at NC State.

The researchers measured aggression by watching for fly actions that include, in order from less aggressive to more aggressive: chasing other flies; puffing up their wings in a "wing threat" position; kicking other flies; and, for the roughest flies, standing on their back legs and boxing other flies with front legs.


'/>"/>

Contact: Dr. Trudy Mackay
trudy_mackay@ncsu.edu
919-515-5810
North Carolina State University
Source:Eurekalert  

Related biology news :

1. Induced neural stem cells: Not quite ready for prime time
2. Preventing cancer, quite naturally
3. Anabolic steroids provide a competitive edge in power lifting years after doping has ended
4. Extinction by asteroid a rarity
5. Smoking during pregnancy may impair thyroid function of mom and fetus
6. Study finds rescue course of antenatal steroids improves outcome in premature babies
7. First comprehensive guidelines for managing medullary thyroid carcinoma published in Thyroid journal
8. Plants on steroids: Key missing link discovered
9. Stem cell success points to way to regenerate parathyroid glands
10. Proposed mission would return sample from asteroid time capsule
11. The fight against uterine fibroid tumors
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Not quite 'roid rage
(Date:1/12/2017)... 12, 2017  Trovagene, Inc. (NASDAQ: TROV ... today announced that it has signed agreements with seven ... the Middle East for commercialization ... the first wave of international distribution agreements for Trovagene,s ... samples. The initial partners will introduce Trovagene,s ...
(Date:1/11/2017)... DES MOINES, Iowa , Jan. 11, 2017 /PRNewswire/ ... another industry first with the release of its patent-pending ... to quickly and reliably perform calibrations, securely upload data ... more flexibility for the customer. "Fighting drunk ... not only for the public at large, but also ...
(Date:1/6/2017)... 5, 2017  SomaLogic announced today that it ... established by iCarbonX, the China ... "Global Digital Health Ecosystem that can define each ... individual,s biological, behavioral and psychological data, the Internet ... companies, SomaLogic will provide proteomics data and applications ...
Breaking Biology News(10 mins):
(Date:1/18/2017)... , ... January 18, 2017 , ... ... essential device-to-computer interconnect using USB or PCI Express, announced the ZEM5310 USB 3.0 ... E FPGA into a compact business-card sized form factor suitable for prototyping, testing, ...
(Date:1/18/2017)... , ... January 18, 2017 , ... ... Clinical Ops Executives 2017 in its continued commitment to the advancement of the ... to discuss current issues related to clinical trial planning and management. , ...
(Date:1/18/2017)... ... ... a new study are stating that if levels of the blood test called prostate ... is still remaining prostate cancer cells that are more likely to come back, spreading and ... indicator of whether a man’s prostate cancer is growing or not,” stated Dr. Samadi. ...
(Date:1/18/2017)... 18, 2017 Shareholder rights law firm Johnson ... the board members of CoLucid Pharmaceuticals, Inc. (NASDAQ: ... with the proposed sale of the Company to Eli ... develops small molecules for the acute treatment of migraines. ... had signed a definitive merger agreement with Eli Lilly. ...
Breaking Biology Technology: