Navigation Links
Not just bleach: Hydrogen peroxide may tell time for living cells
Date:11/3/2009

out to find the signal by probing the action of an enzyme in mitochondria that converts toxic by-products of the body's combustion process into hydrogen peroxide, itself a harmful but less toxic substance which other defenses later break down further.

Tower and his team had noticed that overexpression of the enzyme, known as superoxide dismutase (SOD), boosted the activity level of fruit flies and even increased the life span of certain genetically engineered strains.

Tower suspected that hydrogen peroxide was the key ingredient in SOD's action.

"Hydrogen peroxide is a great candidate for a signaling molecule that would be involved in rhythms and behaviors. It's the most stable and diffusible of the reactive oxygen species (by-products of combustion), but no one had demonstrated a role for it."

As a test, Tower's group administered hydrogen peroxide directly to fruit flies through feeding and injection.

The researchers observed similar effects from the direct administration of hydrogen peroxide and the over-expression of the SOD enzyme.

Both strategies increased the activity levels of adult flies. Long-term direct treatment with hydrogen peroxide suppressed daily rhythms, while SOD over-expression altered those rhythms.

Tower explained that he had not expected identical results from direct treatment versus genetic over-expression.

"I think it's just a little too crude of an intervention, to feed them or inject them with the drug," he said, because those effects will not be rhythmic, whereas production of hydrogen peroxide by the mitochondria and by SOD is expected to be rhythmic and to correspond to the rhythm of metabolism.

Still, the similarities in the flies' reactions to direct treatment and to SOD over-expression suggested to the researchers that hydrogen peroxide is the crucial chemical.

"It's a very exciting result for us that our data now start to point to hydrogen
'/>"/>

Contact: Carl Marziali
marziali@usc.edu
213-740-4751
University of Southern California
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Accolade for solar-hydrogen project
2. Synthetic catalyst mimics natures hydrogen economy
3. Weizmann Institute scientists develop a unique approach for splitting water into hydrogen and oxygen
4. Revealing new applications for carbon nanomaterials in hydrogen storage
5. Hydrogen tank lighter than battery
6. The viability of hydrogen transportation markets: Chicken or egg?
7. A better way to make hydrogen from biofuels
8. Closing the hydrogen economic loop
9. Algae could one day be major hydrogen fuel source
10. Tiny buckyballs squeeze hydrogen like giant Jupiter
11. Project focuses on production of hydrogen from bacteria and sunlight
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/21/2015)... Passwords have proven futile for securing ... U.S. Office of Personnel Management breach. Biometric authentication ... but developers and end-users are concerned about how ... Biometrics-as-a-Service provider HYPR Corp. announced today the general ... party integration. A video overview ...
(Date:7/13/2015)... , Jul. 13, 2015 NXT-ID, Inc. (NASDAQ: ... biometric authentication company focused on the growing mobile ... provisional patent 62/188684 for BEHAVIORAL-DIRECTED AUTHENTIATION ... new convenient and secure method to make payments.  ... payment methods, introduced with its groundbreaking voice-direct payment ...
(Date:7/9/2015)... , July 9, 2015  Unchained Labs ... announcing its acquisition of Avid Nano. Avid Nano ... scattering (DLS) systems.    Also today, ... fastest and easiest to use protein sizing system. ... measures a protein,s hydrodynamic size, size distribution, aggregation ...
Breaking Biology News(10 mins):HYPR Corp. Launches Industry First Biometric Tokenization Platform 2HYPR Corp. Launches Industry First Biometric Tokenization Platform 3HYPR Corp. Launches Industry First Biometric Tokenization Platform 4NXT-ID Patents Behavior-Directed Payments 2NXT-ID Patents Behavior-Directed Payments 3NXT-ID Patents Behavior-Directed Payments 4Unchained Labs just can't get enough, acquires Avid Nano, rocks out the new pUNk! 2
... be having a negative effect on pinyon pine reproduction, ... same woodland ecosystems, says a University of Colorado Boulder-led ... seed cone production declined by an average of about ... and northwestern Oklahoma over the past four decades, said ...
... in the Journal of Applied Physiology, Nutrition, and ... high fructose corn syrup (HFCS) and sucrose (table sugar) at ... fat in humans, a leading cause of non-alcoholic fatty liver ... body of science that high fructose corn syrup and table ...
... techniques may be increasing the severity of an outbreak ... in Central America and Mexico, according to a University ... current outbreak of coffee rust is the worst seen ... arrived in the region more than 40 years ago. ...
Cached Biology News:Southwest regional warming likely cause of pinyon pine cone decline, says CU study 2Southwest regional warming likely cause of pinyon pine cone decline, says CU study 3New study finds neither HFCS nor table sugar increases liver fat under 'real world' conditions 2Modern growing methods may be culprit of 'coffee rust' fungal outbreak 2Modern growing methods may be culprit of 'coffee rust' fungal outbreak 3
(Date:7/30/2015)... ... July 30, 2015 , ... The 2015 Market Research Report ... the current state of the global Propanol market with a focus on the Chinese ... Dow, Carboclor, Mitsui Chemicals, Oxea, ISU Chemical, Sanofi, Royal Dutch Shell, LG Chem and ...
(Date:7/30/2015)... Senomyx , Inc. (NASDAQ: SNMX ), a leading ... and commercialize novel flavor ingredients for the food, beverage, ... the second quarter 2015. "Moving into ... to achieve our commercial and financial goals," stated John ... "Since our last quarterly earnings report, our two partners ...
(Date:7/30/2015)... 2015  Discovery Laboratories, Inc. (Nasdaq: DSCO ... second $1.0M tranche under a previously awarded Phase ... at up to $3.0 million to support continued ... a potential medical countermeasure to mitigate acute and ... an initial $1.0 million under this grant in ...
(Date:7/29/2015)... July 30, 2015 Sanofi, ... publie ses résultats pour le premier semestre 2015. ... les résultats. Visionner l,interview vidéo et ... Au sommaire de l,interview :  ... Moteurs de croissance - Diabète ...
Breaking Biology Technology:Global Propanol Market Technical Data and Manufacturing Analysis 2020 2Global Propanol Market Technical Data and Manufacturing Analysis 2020 3SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 2SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 3SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 4SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 5SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 6SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 7SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 8SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 9Discovery Labs Receives $1.0 million under an SBIR Grant in Continuing Support of the Development of Aerosolized KL4 Surfactant to Address Radiation-Induced Lung Injury 2Discovery Labs Receives $1.0 million under an SBIR Grant in Continuing Support of the Development of Aerosolized KL4 Surfactant to Address Radiation-Induced Lung Injury 3
... of the Israeli,scientists, in a recent survey on creativity, ... them into a creative state and keep,them in this ... Project Mind Foundation and conducted by TNS Teleseker, the,survey ... was raised,one fifth of the total sample expressed a ...
... AMDL, Inc.,(Amex: ADL ), headquartered in ... Jilin, China, is a vertically integrated specialty,pharmaceutical ... Inc. ("JPI"), AMDL engages in the research, ... AMDL announced,that it has entered into an ...
... 2008 BioSpace, the world,s,leading online bioscience job board ... NC(TM) Career Fair on Thursday, May 1, 2008. The ... 11 am to 4 pm., (Logo: http://www.newscom.com/cgi-bin/prnh/20080222/CLF013LOGO ... Carolina will attend the,biotech job fair to meet in ...
Cached Biology Technology:Project Mind Survey of Israeli Ph.D. Scientists Favors a New Standard of Creativity in Science 2Project Mind Survey of Israeli Ph.D. Scientists Favors a New Standard of Creativity in Science 3AMDL Signs Exclusive Licensing Agreement for Human Papilloma Virus Diagnostic Test Kit in Certain Asian Countries 2AMDL Signs Exclusive Licensing Agreement for Human Papilloma Virus Diagnostic Test Kit in Certain Asian Countries 3Bioscience Career Fair in North Carolina Expected to Attract Well Qualified Job Seekers 2
This monoclonal antibody recognizes the light chain of human Factor XII and at 100 nM inhibits 50% of Factor XII activity. It may be used in ELISA to detect human Factor XII and in coagulation assay...
Chicken polyclonal to DCTD ( Abpromise for all tested applications). Antigen: Full length protein (Human) Entrez GeneID: 1635 Swiss Protein ID: P32321...
Mouse monoclonal [SPM325] to Xanthine Oxidase, prediluted ( Abpromise for all tested applications). Antigen: C terminal 358 amino acid fragment of human xanthine oxidase. Entrez Gene ID: 749...
Mouse monoclonal [2G1] to Vancomycin ( Abpromise for all tested applications)....
Biology Products: