Navigation Links
Not by DNA alone: How the epigenetics revolution is fostering new medicines
Date:4/18/2012

Scientific insights that expand on the teachings of Mendel, Watson and Crick, and underpinnings of the Human Genome Project are moving drug companies along the path to development of new medicines based on deeper insights into how factors other than the genetic code influence health and disease. That's the topic of the cover story in the current edition of Chemical & Engineering News (C&EN), the weekly newsmagazine of the American Chemical Society (ACS), the world's largest scientific society.

The article, by C&EN Senior Editor Lisa M. Jarvis, focuses on the quiet revolution in epigenetics that has been sweeping through biology, chemistry and other scientific fields for the last several years. It explains how scientists initially believed that cracking the genetic code, achieved a decade ago, would lay out a straight path for inventing new medicines: Identify the genetic mutation behind a disease and then find a drug that overcomes it. But scientists now know that another layer of biochemical controls, an epigenetics layer, influences how and when genes work in health and disease without changing DNA itself. Early epigenetics research already produced four drugs currently approved to treat blood cancer. But these treatments lack selectivity, limiting their effectiveness.

Now, Jarvis explains, companies like GlaxoSmithKline, Epizyme and Constellation Pharmaceuticals are moving ahead to develop the next generation of epigenetic drugs, particularly for cancer. Armed with a better understanding of how specific epigenetic enzymes are implicated in disease, they are designing compounds to block the activity of those enzymes. The article describes GSK's announcement earlier this month of an epigenetic inhibitor it has developed that might fight lymphoma. "Although no one will know the value of the new epigenetic compounds until they are tested in humans, scientists are confident that the field is moving forward with the right balance of caution and enthusiasm," Jarvis concludes.


'/>"/>

Contact: Michael Bernstein
m_bernstein@acs.org
202-872-6042
American Chemical Society
Source:Eurekalert

Related biology news :

1. Ongoing global biodiversity loss unstoppable with protected areas alone: Study
2. Ali Shilatifard and colleagues aim to clarify the definition of epigenetics
3. New nucleotide could revolutionize epigenetics
4. New piece found in the puzzle of epigenetics
5. Epigenetics could help researchers determine any risks associated with low-dose radiation
6. Study finds diet and alcohol alter epigenetics of breast cancer
7. Largest ever epigenetics project launched
8. Adult stem cells carry their own baggage: Epigenetics guides stem cell fate
9. New international Ph.D. program on Dynamics of Gene Regulation, Epigenetics and DNA Damage Response
10. Inherited epigenetics produced record fast evolution
11. Epigenetics and epidemiology -- hip, hype and science
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/3/2017)... VEGAS , Jan. 3, 2017 Onitor, ... the introduction of Onitor Track, an innovative biometric data-driven ... men, showcasing this month at the 2017 Consumer Electronics ... In the U.S., the World Health ... more than two-thirds of adults who are overweight or ...
(Date:12/20/2016)... Dec, 20, 2016   Valencell , the ... and STMicroelectronics (NYSE: STM), a global semiconductor ... applications, announced today the launch of a new, ... wearables that includes ST,s compact SensorTile ... biometric sensor system. Together, SensorTile and Benchmark ...
(Date:12/16/2016)... YORK , Dec. 16, 2016 The global wearable ... USD 12.14 billion by 2021 from USD 5.31 billion in 2016, ... ... is mainly driven by technological advancements in medical devices, launch of ... rising preference for wireless connectivity among healthcare providers, and increasing focus ...
Breaking Biology News(10 mins):
(Date:1/12/2017)... ... January 12, 2017 , ... Huffman Engineering, Inc. , a ... will work in the company’s Lincoln office as a chemical engineer. In his ... systems for customers in the life science manufacturing and water/wastewater industries. , Prior to ...
(Date:1/12/2017)... -- The report "Direct-Fed Microbials Market by Type (Lactic Acid Bacteria and Bacillus), ... - Global Forecast to 2022", published by MarketsandMarkets, the global market is estimated ... USD 1,399.6 Million by 2022, at a CAGR of 6.96% from 2016. ... ... MarketsandMarkets Logo ...
(Date:1/11/2017)... ... January 11, 2017 , ... ... optics and photonics , are commending the U.S. Congress and President Obama for ... by the President of the American Innovation and Competitiveness Act (AICA). , The ...
(Date:1/11/2017)... (PRWEB) , ... January 11, 2017 , ... ... company developing an innovative cellular response analysis platform to measure the proteomic function ... Phase I Small Business Innovation Research (SBIR) grant from the National Institute on ...
Breaking Biology Technology: