Navigation Links
Not all women in breast cancer families share high risk
Date:11/1/2011

Mothers, sisters and daughters from breast cancer families with known genetic mutations do not all share the same high risk of developing the disease, according to a new international study involving the University of Melbourne.

Women with the breast cancer genetic mutations BRCA1 or BRCA2 are at least 10 times more likely to develop breast cancer than the average woman.

The new study found that women who do not have a genetic mutation, but are closely related to women who do have genetic mutations are at an average risk of developing the disease.

Professor John Hopper from the School of Population Health, University of Melbourne, who led the Australian component of the study, said some women in this scenario were worrying unnecessarily.

"Our study revealed that these women have an average risk of developing the disease as opposed to the high risk of their mutation-carrying close relatives and hence do not need to worry unnecessarily and over screen to detect the disease," he said.

"These findings go against a 2007 clinic-based study in the UK which claimed that all women in breast cancer families with known genetic mutations are at increased risk of developing the disease even if they don't carry the family-specific mutation," he said.

"Our results revealed there was no evidence of increased breast cancer risk for non-carriers of the genetic mutations, certainly not the five-fold increased risk suggested by the authors of the 2007 study."

The international study is the largest analysis to date of breast cancer risk for non-carriers of family specific breast cancer mutations. It was led by Professor Alice Whittemore from Stanford University School of Medicine, USA and was published today in the Journal of Clinical Oncology.

More than 3000 breast cancer families from the population at large were analysed for their genetic risk of the disease. Researchers compared the risk of breast cancer among first-degree relatives of breast cancer patients who did and did not carry a BRCA1 or BRCA2 mutation.

Women were recruited from an international consortium, the Breast Cancer Family Registry, which used population cancer registries in USA, Australia and Canada. The Australian component involved the Australian Breast Cancer Family Registry, led by Professor John Hopper.

Professor Hopper said genetic testing could help to clarify which women are at high or average risk.

"Genetic testing will give women a clearer indication of their real risk level and hence clarify what they could or should not do to reduce their risks of developing beast cancer," he said.

Women who think they might be at increased risk for breast cancer due to a strong family history of the disease can attend Family Cancer Clinics around Australia for genetic testing.


'/>"/>

Contact: Rebecca Scott
rebeccas@unimelb.edu.au
61-383-440-181
University of Melbourne
Source:Eurekalert

Related biology news :

1. Improved living environments can reduce health problems for women and children
2. Womens heart disease tied to small blood vessels
3. 11 women scientists announced as winners of Elsevier Foundation OWSD awards
4. Innovating to improve women and childrens health
5. Increased celiac disease prevalence in women with unexplained infertility
6. SUNY Downstate researchers identify possible new targets for treating pain in women
7. Pregnant women in Vancouver may not be getting enough vitamin D
8. B-cell discovery suggests why women suffer more autoimmune disease
9. U of M researchers may have discovered key to help women fight infections during pregnancy
10. Greater seizure frequency seen in women with epilepsy during anovulatory cycle
11. PSA test for men could get a second life for breast cancer in women
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/20/2016)... DALLAS , June 20, 2016 ... criminal justice technology solutions for public safety, investigation, ... by the prisons involved, it has secured the ... Corrections (DOC) facilities for Managed Access Systems (MAS) ... (4) additional facilities to be installed by October, ...
(Date:6/15/2016)... New York , June 15, 2016 /PRNewswire/ ... a new market report titled "Gesture Recognition Market by ... and Forecast, 2016 - 2024". According to the report, ... USD 11.60 billion in 2015 and is estimated ... reach USD 48.56 billion by 2024.  ...
(Date:6/9/2016)... , June 9, 2016 ... Police deploy Teleste,s video security solution to ensure the safety ... France during the major tournament Teleste, ... communications systems and services, announced today that its video security ... to back up public safety across the country. ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... (PRWEB) , ... June 23, 2016 , ... ... the release of its second eBook, “Clinical Trials Patient Recruitment and Retention Tips.” ... and retention in this eBook by providing practical tips, tools, and strategies for ...
(Date:6/23/2016)... June 23, 2016 Houston Methodist Willowbrook ... Cy-Fair Sports Association to serve as their official ... Houston Methodist Willowbrook will provide sponsorship support, athletic ... with association coaches, volunteers, athletes and families. ... Cy-Fair Sports Association and to bring Houston Methodist ...
(Date:6/23/2016)... ... June 23, 2016 , ... Supplyframe, the Industry Network ... Supplyframe Design Lab . Located in Pasadena, Calif., the Design Lab’s mission is ... projects are designed, built and brought to market. , The Design Lab is ...
(Date:6/23/2016)... Andrew D Zelenetz ... Published recently in Oncology ... touchONCOLOGY, Andrew D Zelenetz , discusses the ... is placing an increasing burden on healthcare systems ... With the patents on many biologics expiring, interest ...
Breaking Biology Technology: