Navigation Links
Not all women in breast cancer families share high risk
Date:11/1/2011

Mothers, sisters and daughters from breast cancer families with known genetic mutations do not all share the same high risk of developing the disease, according to a new international study involving the University of Melbourne.

Women with the breast cancer genetic mutations BRCA1 or BRCA2 are at least 10 times more likely to develop breast cancer than the average woman.

The new study found that women who do not have a genetic mutation, but are closely related to women who do have genetic mutations are at an average risk of developing the disease.

Professor John Hopper from the School of Population Health, University of Melbourne, who led the Australian component of the study, said some women in this scenario were worrying unnecessarily.

"Our study revealed that these women have an average risk of developing the disease as opposed to the high risk of their mutation-carrying close relatives and hence do not need to worry unnecessarily and over screen to detect the disease," he said.

"These findings go against a 2007 clinic-based study in the UK which claimed that all women in breast cancer families with known genetic mutations are at increased risk of developing the disease even if they don't carry the family-specific mutation," he said.

"Our results revealed there was no evidence of increased breast cancer risk for non-carriers of the genetic mutations, certainly not the five-fold increased risk suggested by the authors of the 2007 study."

The international study is the largest analysis to date of breast cancer risk for non-carriers of family specific breast cancer mutations. It was led by Professor Alice Whittemore from Stanford University School of Medicine, USA and was published today in the Journal of Clinical Oncology.

More than 3000 breast cancer families from the population at large were analysed for their genetic risk of the disease. Researchers compared the risk of br
'/>"/>

Contact: Rebecca Scott
rebeccas@unimelb.edu.au
61-383-440-181
University of Melbourne
Source:Eurekalert

Page: 1 2

Related biology news :

1. Improved living environments can reduce health problems for women and children
2. Womens heart disease tied to small blood vessels
3. 11 women scientists announced as winners of Elsevier Foundation OWSD awards
4. Innovating to improve women and childrens health
5. Increased celiac disease prevalence in women with unexplained infertility
6. SUNY Downstate researchers identify possible new targets for treating pain in women
7. Pregnant women in Vancouver may not be getting enough vitamin D
8. B-cell discovery suggests why women suffer more autoimmune disease
9. U of M researchers may have discovered key to help women fight infections during pregnancy
10. Greater seizure frequency seen in women with epilepsy during anovulatory cycle
11. PSA test for men could get a second life for breast cancer in women
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/17/2014)... in German . ... day in order to reproduce? And why are there two ... the latest issue of the research journal Molecular Human ... Steven Ramm from Bielefeld University Bielefeld has compiled this special ... for a female to copulate with several males in quick ...
(Date:10/17/2014)... in German . ... drugs. When treating overdoses, doctors are often limited to supportive ... there is a combination of drugs involved. So what can ... his grandmother,s pills? ETH professor Jean-Christophe Leroux from the Institute ... answer to this question. "The task was to develop an ...
(Date:10/16/2014)... of Marine Science have received a 3-year, $392,773 ... the streams and wetlands most vulnerable to sea-level ... governments and citizens conserve these important ecosystems. , ... tidal-marsh observations first gathered by VIMS scientists in ... today,s researchers accurately map the slow but inexorable ...
Breaking Biology News(10 mins):Sperm wars 2Emergency aid for overdoses 2Emergency aid for overdoses 3EPA grant will help localities conserve headwater wetlands 2EPA grant will help localities conserve headwater wetlands 3
... one of the less common types of skin cancer but it ... percent). The five-year survival rate for early stage melanoma is ... cancer is detected late or there is recurrence. So a ... the goal is to remove as little tissue as possible while ...
... University of Maryland, in partnership with the University of ... received a $7.9 million federal grant to acquire a ... will help researchers unravel the mysteries of molecules and ... diseases. The grant is among the largest of ...
... Instructor in Medicine, University of Washington, and Associate, Human ... been chosen by the American Society for Microbiology (ASM) ... her outstanding work elucidating the role of neutralizing antibodies ... Health Division, this award recognizes an early career scientist ...
Cached Biology News:Seeing melanoma 2Seeing melanoma 3University of Maryland partnership receives $7.9M from NIH for superconducting research magnet 2University of Maryland partnership receives $7.9M from NIH for superconducting research magnet 3
(Date:10/25/2014)... (PRWEB) October 24, 2014 Today, Nerium ... announced the winners of its “Reflect Your Youth” contest, ... not only seen a difference in their skin since ... a new outlook on life as a result of ... originated as an effort by Nerium International to inspire ...
(Date:10/25/2014)... NEW YORK , Oct. 24, 2014 ... Access Pharmaceuticals, Inc. (ACCP), a biopharmaceutical company advancing ... implemented a 1-for-50 reverse split of its common ... Friday, October 24, 2014. PlasmaTech,s common stock will ... number 72754H109 and temporary ticker symbol "ACCPD". After ...
(Date:10/22/2014)... NEW YORK , Oct. 22, 2014 ... growth in the in vitro diagnostic (IVD) test industry, ... Kalorama Information. The healthcare market researcher listed more than 25 ... that could be the future of IVD products. Kalorama details ... industry, The Worldwide Market for In Vitro Diagnostic ...
(Date:10/22/2014)... Shimadzu Scientific Instruments introduces its Open ... the pain management and clinical markets. The software increases ... by allowing users to highlight and review results that ... allows analysts to filter results by group or based ... eliminating the need to sift through analytes of no ...
Breaking Biology Technology:Nerium International™ Inspires Conversation About the Journey of Aging with “Reflect Your Youth” Contest 2PlasmaTech Biopharmaceuticals, Inc. Announces Reverse Stock Split, Ticker Change and Launches New Corporate Website 2Report: Radical New IVD Test Approaches Key To Growth 2Report: Radical New IVD Test Approaches Key To Growth 3Shimadzu Releases QuantAnalytics Open Access LCMS Software Package for Clinical Applications 2
... This week Jonathan Watson will become the first student to ... engineering dual degree program . , ,Watson, a native of ... UW-Eau Claire and his bachelors degree in engineering from the ... great advantage in preparing for engineering course work because I ...
... and PowerPoint slides online is not enough, faculty and staff ... audio to liven up their course Web pages thanks to ... grant. , ,The services web site, Streaming Media at ... the production of streaming video and audio, comparisons of different ...
... has a new home: Health Sciences Learning Center ... health sciences on the UW-Madison campus. , ,Part of this ... DeLuca , associate dean for research and graduate studies at ... nursing, pharmacy and physical therapy students in one facility. DeLuca ...
Cached Biology Technology:Student to graduate in the Dual Degree Physics and Engineering Program 2University of Wisconsin enriches course web sites with streaming media 2UW Medical School to build Health Sciences Learning Center 2
... Extracts are optimized for maximum packaging efficiencies ... high efficiency extracts (> 109 pfu/g with ... a library containing at least 5 ... extracts are made from a specially designed ...
... 6 delivers enhanced statistics and statistical ... quality improvement managers. As an accepted ... 6 simplifies statistics for novice users ... by experts. It offers a powerful ...
... Mouse anti-Yersinia pestis F1 antigen, Monoclonal ... ELISA: Use at an ... an assay dependent dilution. WB: Use ... molecular weight: 18 kDa. Not tested ...
...
Biology Products: