Navigation Links
Northwestern study tests drug against Parkinson's disease
Date:4/1/2014

CHICAGO --- Tanya Simuni, M.D., medical director of Northwestern University's Parkinson's Disease and Movement Disorders Center, was awarded a grant from the National Institutes of Health (NIH) to conduct a $16 million phase III study of the safety and efficacy of the drug isradipine as a potential neuroprotective agent in Parkinson's disease.

This is the only phase III Parkinson's neuroprotective study currently funded by the National Institute of Neurological Disorders and Stroke at NIH. The research is being conducted by Northwestern University Feinberg School of Medicine in partnership with the University of Rochester Medical Center. The study will be carried out at 56 Parkinson Study Group centers in North America over five years.

"If this drug proves to be safe and effective, it will change the way we treat Parkinson's disease," said Simuni, the principal investigator of the study. "The major advantage is isradipine is already widely available and inexpensive and will allow for rapid translation of our research into clinical practice. Although we now have very effective symptomatic treatments to manage Parkinson's, the development of a disease-modifying intervention remains the Holy Grail."

Simuni is the Arthur C. Nielsen, Jr. Research Professor in Parkinson's Disease and Movement Disorders at Feinberg and a neurologist at Northwestern Memorial Hospital.

Parkinson's is the second most common neurodegenerative disease. Prominent traits include tremor, stiffness of the limbs and trunk, slowness of movement and impaired balance and coordination. While there are pharmaceutical and alternative therapies available to manage the disease, there are currently no cures or treatments that definitively slow its progression. Researchers are looking for treatments to delay disease progression. If isradipine proves effective, the drug could revolutionize the treatment of Parkinson's.

Isradipine has been approved by the Food and Drug Administration as a calcium-channel blocker to treat hypertension (high blood pressure). By inhibiting the excessive flow of calcium, it may also stunt certain adverse cellular functions.

Researchers have speculated that imbalances in calcium may contribute to cellular toxicity and the death of dopamine-producing neurons in the brain that lead to Parkinson's. Dopamine is a critical chemical messenger in the brain that directs a person's ability to move. It is hypothesized that isradipine will slow the progression of the disease by protecting dopamine-producing neurons from toxicity over an extended period of time.

Academic colleagues at Feinberg will collaborate with Simuni on this study, including D. James Surmeier, the Nathan Smith Davis Professor of Physiology and director of the Udall Center of Excellence for Parkinson's Disease Research. Surmeier, the chair of physiology, and his team of researchers discovered the possible relationship between isradipine and Parkinson's disease. The physiology department Surmeier heads is one of the nation's premier groups studying the physiology of movement disorders.


'/>"/>

Contact: Marla Paul
marla-paul@northwestern.edu
312-503-8928
Northwestern University
Source:Eurekalert

Related biology news :

1. Grants add to Northwestern-Qatar partnership
2. UCSB scientists compile first study of potential for tsunamis in northwestern California
3. Northwestern scientists create chemical brain
4. Northwestern researchers examine mechanical bases for the emergence of undulatory swimmers
5. Fish species unique to Hawaii dominate deep coral reefs in Northwestern Hawaiian Islands
6. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
7. Law that regulates shark fishery is too liberal: UBC study
8. New study will help protect vulnerable birds from impacts of climate change
9. Study jointly led by UCSB researcher supports theory of extraterrestrial impact
10. BYU study: Using a gun in bear encounters doesnt make you safer
11. 15-year study: When it comes to creating wetlands, Mother Nature is in charge
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2016)... SAN FRANCISCO and BANGALORE, India ... part of EdgeVerve Systems, a product subsidiary of Infosys (NYSE: ... service provider, today announced a global partnership that ... convenient way to use mobile banking and payment services. ... Mobility is a key innovation area for financial services, but ...
(Date:4/26/2016)... 2016 Research and Markets has ... Market 2016-2020"  report to their offering.  , ,     ... The analysts forecast the global multimodal biometrics market ... the period 2016-2020.  Multimodal biometrics is ... as the healthcare, BFSI, transportation, automotive, and government ...
(Date:4/15/2016)... -- Research and Markets has announced the ...  report to their offering.  ,      ... gait biometrics market is expected to grow at ... Gait analysis generates multiple variables such ... compute factors that are not or cannot be ...
Breaking Biology News(10 mins):
(Date:5/4/2016)... ... May 05, 2016 , ... CereScan, ... the National Stroke Association during National Stroke Awareness Month in May. An ... pages throughout the month. CereScan will donate $1 up to a maximum ...
(Date:5/4/2016)... ... May 04, 2016 , ... The Children’s Tumor Foundation announced its annual month-long ... grow on nerves throughout the body. It affects 1 in 3,000 people of all ... during the month of May, as well as online activities, Neurofibromatosis Awareness Month and ...
(Date:5/3/2016)... PUNE, India , May 3, 2016 ... Type (DNA Chip (Genomics, Drug Discovery, Gene ... Chips), End user (Academics Institutes, Diagnostics Centers), ... 2020" published by MarketsandMarkets, the market is ... 2020 from USD 7.63 Billion in 2015, ...
(Date:5/3/2016)... ... 2016 , ... Flagship Biosciences, the leader in tissue ... of Directors. Dr. Gillett recently retired from Charles River Laboratories (CRL), where, in ... Officer. A board-certified veterinary pathologist, Dr. Gillett joined Charles River in 1999 through ...
Breaking Biology Technology: