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Northwestern Memorial trial may wean kidney transplant patients off antirejection drugs
Date:1/23/2008

lled leukopheresis, happening one day apart, where stem cells mobilized from the marrow are collected so that they can be given to the kidney recipient to help his body acclimate to the transplant.

Approximately one month before the transplant surgery, the recipient undergoes leukopheresis to draw white blood cells which are stored in a lab for later testing. After transplant surgery, the recipient receives four separate infusions of donor stem cells.

The stem cells are infused into the transplant recipient via an IV in a procedure that lasts about 15 minutes. The first infusion is five days after surgery, the next is about three months after surgery, then six months and finally nine months after the transplant. During this time the recipient is treated with Campath-1H, a potent antibody used extensively at Northwestern to prevent rejection, in addition to the other standard anti-rejection medications. About a year after the surgery, the subject is weaned off of one anti-rejection drug, then another. There are also ongoing tests to ensure the recipient is tolerating the kidney.

This is an exciting area of research which holds a great deal of promise if successful, says Dr. Abecassis. We are excited to be the only center in the region offering this to qualifying patients.


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Contact: Amy Dobrozsi
adobrozs@nmh.org
312-926-5900
Northwestern Memorial Hospital
Source:Eurekalert

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