Navigation Links
Northwestern Memorial trial may wean kidney transplant patients off antirejection drugs
Date:1/23/2008

CHICAGO After a transplant surgery, anti-rejection drugs for the organ recipient are a must, but with prolonged use can have serious side effects, including infections, heart disease and cancer. A team led by Joshua Miller, MD, a researcher at Northwestern Universitys Feinberg School of Medicine, is working with Northwestern Memorial Hospitals department of organ transplantation to enroll qualifying subjects in a new research study that seeks to transplant stem cells from a kidney donors bone marrow into the recipient, with the hope of gradually eliminating the need for anti-rejection drugs. If research proves successful, it would mean a dramatic change in the post-transplant quality of life for the transplant recipient.

Northwestern is the only center in Chicago and one of four centers nationally looking at this topic. The Feinberg School of Medicine has received a four-year, $2.5 million grant from the National Institutes of Health to enroll 20 patients in the study, which is called "Donor Stem Cells, Campath, T/B Cell Regulation In HLA-Identical Renal Transplants."

The first subjects to participate in the study underwent kidney transplant surgery on Thursday, Jan. 10. Sharon Flood of Pingree Grove, Ill. donated her kidney to her brother Steven Yelk of Gurnee, Ill., who suffers from polycystic kidney disease (PKD), which causes cysts filled with fluid to form throughout the kidneys. Eventually, these cysts take over the healthy kidney tissue and the kidneys fail. Our family is very close and there are seven brothers and sisters, I was thrilled to learn that I was a match and would be able to help Steven, Sharon commented before the surgery.

Joseph Leventhal, MD, PhD, transplant surgeon, associate professor of surgery and director of the Living Donor Renal Transplant Program at Northwestern Universitys Feinberg School of Medicine, preformed the kidney donors surgery and Michael Abecassis, MD, MBA, chief of the division of transplantation, and dean of clinical affairs for Northwestern Universitys Feinberg School of Medicine, performed the recipients surgery.

The surgery was successful, everything went according to plan and the new kidney is functioning well, said Dr. Abecassis. From here, the kidney recipient will begin the experimental portion of the study.

This study is open to HLA-identical sibling kidney donor and recipient pairs. HLA, or human leukocyte antigen, is one of a group of proteins found on the surface of white blood cells and other cells that play an important part in the body's immune response to foreign substances. These antigens vary from person to person, and an HLA compatibility test is performed before organ transplantation to find out if tissues match between a donor and a recipient.

The study is limited to only HLA-identical sibling pairs because these siblings genetically have a more similar set of immunologic markers than a non-related HLA-identical pair. Because this population has the closest genetic relationship, they have the best chance for success with the study. Overall, HLA-identical siblings have very low rejection rates for kidney transplants but until now have still required immunosuppressive drugs to be taken for life.

How does it work?

Stem cells are formed at the marrow and are common blood cells from which other specialized blood cells, like immune cells, develop. These stem cells are considered important to help prevent rejection of the kidney transplant. By transplanting these cells from the kidney donor into the recipient, the study seeks to prove that the stem cells will mature in the recipients body and will allow his immune system to accept the new organ as his own.

For the kidney donor, the laparoscopic surgery occurs in the standard manner. After the kidney is removed, bone marrow is drawn from the donors hip bone. About three months following the surgery, the donor undergoes two procedures called leukopheresis, happening one day apart, where stem cells mobilized from the marrow are collected so that they can be given to the kidney recipient to help his body acclimate to the transplant.

Approximately one month before the transplant surgery, the recipient undergoes leukopheresis to draw white blood cells which are stored in a lab for later testing. After transplant surgery, the recipient receives four separate infusions of donor stem cells.

The stem cells are infused into the transplant recipient via an IV in a procedure that lasts about 15 minutes. The first infusion is five days after surgery, the next is about three months after surgery, then six months and finally nine months after the transplant. During this time the recipient is treated with Campath-1H, a potent antibody used extensively at Northwestern to prevent rejection, in addition to the other standard anti-rejection medications. About a year after the surgery, the subject is weaned off of one anti-rejection drug, then another. There are also ongoing tests to ensure the recipient is tolerating the kidney.

This is an exciting area of research which holds a great deal of promise if successful, says Dr. Abecassis. We are excited to be the only center in the region offering this to qualifying patients.


'/>"/>

Contact: Amy Dobrozsi
adobrozs@nmh.org
312-926-5900
Northwestern Memorial Hospital
Source:Eurekalert

Related biology news :

1. Northwestern study looks at sensing, movement and behavior
2. Northwestern to expose most deadly infectious diseases in 3-D
3. Researchers at Sarasota Memorial Health Care System to study airway bypass treatment for emphysema
4. Nucleonics initiates hepatitis B clinical trial with expressed interfering RNA therapeutic
5. New clinical trial results show how personalized medicine will alter treatment of genetic disorders
6. New model revises estimates of terrestrial carbon dioxide uptake
7. Study of African traditional medicine will begin world-first clinical trial
8. Small-scale fishing in Mexico rivals industrial fisheries in accidental turtle deaths
9. Contrast agent trials in swine
10. The industrial space age
11. Trial seeks genetic fingerprint for predicting drug effectiveness
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/20/2016)... -- Securus Technologies, a leading provider of civil ... investigation, corrections and monitoring announced that after exhaustive ... the final acceptance by all three (3) Department ... (MAS) installed. Furthermore, Securus will have contracts for ... October, 2016. MAS distinguishes between legitimate wireless device ...
(Date:6/9/2016)... 2016 Paris Police Prefecture ... security solution to ensure the safety of people and operations ... the major tournament Teleste, an international technology group ... announced today that its video security solution will be utilised ... up public safety across the country. The system roll-out is ...
(Date:6/2/2016)... YORK , June 2, 2016   The Weather ... is announcing Watson Ads, an industry-first capability in which consumers ... by being able to ask questions via voice or text ... Marketers have long sought ... the consumer, that can be personal, relevant and valuable; and ...
Breaking Biology News(10 mins):
(Date:11/30/2016)... Nov. 30, 2016  GenomOncology today announced the appointment of ... Medical Affairs.  Dr. Coleman will oversee clinical ... proprietary knowledge-enabled platform. The GenomOncology software suite empowers molecular pathologists ... data and clinical decision support, from quality control through reporting. ... , , ...
(Date:11/30/2016)... , Nov. 30, 2016 Biotest Pharmaceuticals Corporation ... pleased to announce the addition of its newest plasma ... Kearney, Nebraska . The 15,200 square foot state-of-the-art ... 29th, 2016 and brings the total number of BPC,s ... Ileana Carlisle , BPC,s Chief Executive Officer said "We ...
(Date:11/30/2016)... 2016  Tempus, a technology company focused on ... Abramson Cancer Center have partnered to better determine ... immunotherapy treatment based on next generation genomic and ... a research collaboration, Tempus will provide sequencing and ... data to Penn. Utilizing next-generation sequencing, machine learning ...
(Date:11/30/2016)... GREENWICH, Connecticut , November 30, 2016 ...   ... Aptuit, LLC today announced ... screening library. An additional 150,000 novel compounds have increased the ... selected to broaden the hit discovery capabilities of the company. ...
Breaking Biology Technology: