Navigation Links
North Carolina-based genetic resources fuel big scientific progress
Date:2/16/2012

A series of 15 scientific papers published this week in the journals of the Genetics Society of America (Genetics and G3: Genes|Genomes|Genetics) put North Carolina at the epicenter of a scientific resource called the Collaborative Cross a "library" of genetic diversity that scientists believe can help fast-track important discoveries about genetics and disease into new discoveries, tests, and treatments that impact human health.

Researchers have long been frustrated by promising lab results that hit obstacles on the road to human application. Sometimes this is because research in other living organisms is very limited in terms of what conclusions scientists can safely extrapolate to the human population as a whole. One reason for this problem is that organisms studied in the laboratory lack the genetic diversity of humans.

To overcome this obstacle, scientists have begun to create libraries of genetic material. These libraries called Genetic Resource Panels (GRPs) enable researchers to look at how genetic variation impacts living systems in a careful and systematic manner an approach that they think will help draw more robust conclusions, often more quickly.

The Collaborative Cross, a project aimed at mirroring the diversity of human genetics in the laboratory mouse population, is one such GRP. The Collaborative Cross contains ten times the genetic diversity of a typical laboratory mouse population a level equivalent to the natural genetic variation in humans. Furthermore, the genetic diversity is spread out across the genome of the Collaborative Cross, while the limited ancestry of typical laboratory mice means that about half of the genome lacks good data for geneticists. The Collaborative Cross fills in those gaps, and the result for scientists is a fast track to understanding and testing new treatment and prevention approaches for numerous human diseases with an underlying genetic component.

Th
'/>"/>

Contact: Ellen de Graffenreid
edegraff@med.unc.edu
919-962-3405
University of North Carolina School of Medicine
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Research around the North Pole
2. Northwest climate change is target of $3.2M in grants to University of Oregon
3. Genetic evidence for avian influenza movement from Asia to North America via wild birds
4. North American environmental commission launches trinational vaquita conservation plan
5. West Niles North American spread described
6. Dried mushrooms slow climate warming in Northern forests
7. Wildfires result in loss of forests reserved by Northwest Forest Plan
8. Queens University biologists find new environmental threat in North American lakes
9. GKSS to invest 12 million euros ($15.48 million) in a new observation system for the North Sea
10. Methyl bromide alternatives indicated for North Carolina tomato production
11. Darwin anniversary heralds new conservation research era for Northern Ireland
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... Clinic researcher and his collaborators have developed an online ... process of re-engineering cells for biomedical investigation. CellNet is ... to aid stem cell engineering. Details of CellNet and ... two back-to-back papers in the journal Cell . ... uses for all types of cell-based investigations and can ...
(Date:8/28/2014)... MD FASEB MARC (Maximizing Access to Research ... for the Genetics Society of America,s 27th Annual ... October 3, 2014 in Pacific Grove, California. ... of students, post doctorates and scientists from underrepresented ... community and to encourage the participation of young ...
(Date:8/28/2014)... -- Scientists have identified the developmental on-off switch for ... produce more than two-thirds of the world,s naturally derived ... to see whether it is possible to manipulate this ... , The study, appearing August 28 in Cell ... molecule called cyclic-di-GMP and a larger protein called BldD ...
Breaking Biology News(10 mins):New tool aids stem cell engineering for medical research 2Small molecule acts as on-off switch for nature's antibiotic factory 2Small molecule acts as on-off switch for nature's antibiotic factory 3
... The World Science Festival launches its first full day with ... will feature a keynote address by Harold Varmus, co-chair of ... well as a live simulcast of the announcement of the ... Oslo, Norway. A panel discussion follows, moderated by Elizabeth ...
... (May 14, 2010)--The New York Stem Cell Foundation (NYSCF) ... Robertson Foundation, established by Julian and Josie Robertson. ... will provide funding for NYSCF-Robertson Investigators in NYSCF,s new ... the NYSCF-Robertson Stem Cell Prize. This award ...
... 2010 The same digital technology that enables young people ... immerse them in a simulated coral reef environment where they ... project led by Field Museum scientists will link students from ... reef environments in the Pacific Ocean, engage in the scientific ...
Cached Biology News:Field Museum technology project wins prestigious award 2
(Date:8/29/2014)... , Aug. 29, 2014 /PRNewswire/ - iCo Therapeutics ... today reported financial results for the six months ... are expressed in Canadian dollars and presented under ... Quarter 2014 Highlights , Announced top-line ... (VA) primary endpoint for subjects enrolled in the ...
(Date:8/29/2014)... 2014 Three Lawrence Livermore researchers ... Hydrogen Production R&D Award for their research ... using sunlight. , Shared with collaborators from the ... of Nevada, Las Vegas (UNLV), the award recognizes ... photoelectrochemical solar-hydrogen production and corrosion processes. , These ...
(Date:8/29/2014)... 2014 A major challenge before new ... dense realm of Boston-Cambridge, is gaining visibility that can ... Sherley, the Director of Boston’s Adult Stem Cell Technology ... national visibility of his company an important priority since ... addition to a social media marketing campaign ...
(Date:8/28/2014)... SAN DIEGO, California, USA (PRWEB) August 28, 2014 ... at the Department of Physics and Optical Science and ... at the University of North Carolina at Charlotte, and ... has been elected to serve as the 2015 Vice ... photonics. , SPIE 2014 President Philip Stahl announced recent ...
Breaking Biology Technology:iCo Therapeutics Announces Second Quarter 2014 Financial Results 2iCo Therapeutics Announces Second Quarter 2014 Financial Results 3iCo Therapeutics Announces Second Quarter 2014 Financial Results 4Livermore Team Awarded for Hydrogen Production Research 2The Adult Stem Cell Technology Center, LLC Participates in Multiple Stem Cell and Regenerative Medicine Conferences Before Year End 2The Adult Stem Cell Technology Center, LLC Participates in Multiple Stem Cell and Regenerative Medicine Conferences Before Year End 3The Adult Stem Cell Technology Center, LLC Participates in Multiple Stem Cell and Regenerative Medicine Conferences Before Year End 4Glenn Boreman, UNC Professor and Plasmonics Co-Founder, Elected to SPIE Presidential Chain 2
... Veteran healthcare executive brings solid experience with international ... healthcare and technology companies, ... management tools, announced the appointment of,Guillermo Moreno as its vice ... for developing and implementing strategic,initiatives to grow the company,s business ...
... Corporation,(Nasdaq: SIAL ) will be presenting at the ... at 8:30 AM ET at the Grand Hyatt in,New ... broadcast over the,Internet available at http://ir.sigmaaldrich.com . Users ... the webcast on, http://ir.sigmaaldrich.com users will need to ...
... FREMONT, Calif., Sept. 17 Quark ... and developing novel,RNA interference (RNAi)-based therapeutics, ... the 5th Annual RNAi Europe, taking ... Three of Quark,s scientists,Igor Mett, Hagar ...
Cached Biology Technology:Guillermo Moreno Named Aurillion's Vice President of Sales and Marketing 2Quark Pharmaceuticals Announces Poster Presentations at RNAi Europe 2008 2Quark Pharmaceuticals Announces Poster Presentations at RNAi Europe 2008 3
... Isothermal Block is an anodized aluminum, solvent-resistant ... and to provide efficient thermal transfer to ... design of the HT96 Isothermal Block replaces ... product design allowing for compatibility with robotic ...
Human monocyte-derived dendritic cells, For immunohistochemistry (IHC) Cell Chip with Human Peripheral Blood Dendritic Cells and EPCs...
...
...
Biology Products: