Navigation Links
Normal-looking sperm may have serious damage; scientists urge more care in selection
Date:7/8/2008

on by fluorescence microscopy. The sperm morphology was evaluated in 400 randomly selected cells per sample. When a sperm with normal morphology was found, the light was switched to fluorescence to determine DNA integrity. Sperm with normal morphology from the fertile group showed no evidence of DNA fragmentation. But in the infertile men, between 20 and 66% of normal-looking sperm had DNA damage.

"The origin of DNA fragmentation can be multi factorial," said Mr. Avendao. "Oxidative stress (mainly due to reproductive tract infections) and apoptosis are the most studied, but other factors as age, smoking, exposure to air pollution and abnormal testicular warming are believed to increase the proportion of sperm DNA fragmentation."

The researchers are now applying DNA fragmentation evaluation to couples with male factor infertility. "Our preliminary results using this new evaluation method show a clear negative correlation between the percentage of DNA fragmented sperm and the embryo quality and pregnancy outcome," said Mr. Avendao.

"Different research groups have shown that in addition to affecting normal embryonic development, fertilisation with damaged spermatozoa resulting in a live-born infant can be associated with increased chromosomal abnormalities, minor or major birth defects, and even childhood cancer," said Mr. Avendao. "Our work has shown that normal sperm morphology alone should not be used as the unique attribute for the selection of sperm for ICSI. New methods that allow an accurate separation of sperm with intact DNA should be sought."

Sperm biology has received less attention since the introduction and success of the ICSI technique, say the researchers. "While the ICSI procedure bypasses the natural sperm selection, we believe that the deleterious effects of injecting a DNA-fragmented sperm should and can be avoided. Further research into sperm biology is essential if we are to avoid problems in the future," said
'/>"/>

Contact: Mary Rice
mary@mrcommunication.org
34-932-308-810
European Society for Human Reproduction and Embryology
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Wiggle room: Cornell researcher borrows idea from sperm to provide energy for nanoscale robots
2. Mutant sperm guide clinicians to new diseases
3. Primate sperm competition: speed matters
4. Bacterial slime helps cause serious disease
5. Oceanic sharks worldwide at serious risk from high-seas fishing, rising demand for shark products
6. West Nile virus spread through nerve cells linked to serious complication
7. Study finds blocking angiogenesis signaling from inside cell may lead to serious health problems
8. Biodiversity maps developed by UCSD scientists will help guide conservation measures in East Africa
9. Scientists integrate data in three dimensions to study climate effects on young fish
10. Scientists set out to measure how we perceive naturalness
11. Scientists reveal the key mechanisms for affinity between transient binding proteins
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... Using spider toxins to study the proteins that let ... say they have stumbled upon a biological tactic that ... insect plagues in a safe and environmentally responsible way. ... be lethal for one species and harmless for a ... target specific pests without harming beneficial species like bees. ...
(Date:7/10/2014)... June 27, 2014  The American Academy of ... of Standards and Technology (NIST) and the Department ... research and forensic science expert members to the ... an element of the NIST,s Organization of Scientific ... the first appointments made to the new FSSB ...
(Date:7/10/2014)... 1, 2014 Smart technology emphasis grows ... and improved security: NXT-ID, Inc. (OTCBB: NXTD), eBay Inc. (NASDAQ: ... ), Apple Inc. (NASDAQ: AAPL ), Visa Inc. ... NXT-ID, Inc., (OTCQB: NXTD) a biometric authentication company focused ... the second series of 30 second spots on CNBC for ...
Breaking Biology News(10 mins):Potent spider toxin 'electrocutes' German, not American, cockroaches 2Potent spider toxin 'electrocutes' German, not American, cockroaches 3Ten Members of the American Academy of Forensic Sciences Appointed to Forensic Science Standards Board (FSSB) 2Ten Members of the American Academy of Forensic Sciences Appointed to Forensic Science Standards Board (FSSB) 3Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 2Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 3Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 4Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 5
... four genes newly associated with severe childhood obesity. They ... in severely obese children. The team found that ... to maintain protein receptors known to be involved in ... for the development of new drugs against obesity. ...
... UNTIL 1 P.M. EDT, APRIL 7, 2013, Cleveland: A compound ... popular energy drinks has been found to promote atherosclerosis ... to Cleveland Clinic research published online this week in the ... that bacteria living in the human digestive tract metabolize the ...
... Kidney stones usually make their presence known suddenly, often ... Each year in the U.S. more than a million ... nephrolithiasis. The total annual cost of treatment exceeds $2.1 ... Information Clearinghouse. Although kidney stone pain may ...
Cached Biology News:Finding genes for childhood obesity 2Cleveland Clinic researchers discover new link between heart disease and red meat 2Cleveland Clinic researchers discover new link between heart disease and red meat 3Flies reveal kidney stones in-the-making 2Flies reveal kidney stones in-the-making 3
(Date:7/10/2014)... PETERSBURG, Russia , July 10, 2014 ... Russian Federation Dmitry Medvedev , presented ... biopharmaceutical company BIOCAD . The Company is developing ... scope of MabNext project BIOCAD develops a number of ... cancer and autoimmune diseases. The ceremony took place at ...
(Date:7/10/2014)...   Ceres, Inc . (Nasdaq: CERE ... financial results for the three months ended May 31, ... Ceres reported that the company and its customers ... season in Brazil, which concluded in June, despite dry ... areas for part of the growing season. Yields of ...
(Date:7/10/2014)... published today in the journal PNAS (Proceedings of ... time of day and sleep deprivation have a significant ... when looking at the best time of day to ... and for administering medicines effectively. , Researchers from the ... London, investigated the links between sleep deprivation, body clock ...
(Date:7/10/2014)... upside down forever. Nanophysics makes sure of that. Mechanics researchers ... published in Physical Review E . Knowledge that can ... seem to be able to sit still forever, and walk ... We will soon be able to buy smart new fasteners ... the fact is, sooner or later the grip is lost, ...
Breaking Biology Technology:Dmitry Medvedev Presented BIOCAD the First National "Industry" Award 2Ceres Announces Fiscal Third Quarter 2014 Financial Results 2Ceres Announces Fiscal Third Quarter 2014 Financial Results 3Ceres Announces Fiscal Third Quarter 2014 Financial Results 4Ceres Announces Fiscal Third Quarter 2014 Financial Results 5Ceres Announces Fiscal Third Quarter 2014 Financial Results 6Ceres Announces Fiscal Third Quarter 2014 Financial Results 7Ceres Announces Fiscal Third Quarter 2014 Financial Results 8Ceres Announces Fiscal Third Quarter 2014 Financial Results 9Time of day crucial to accurately test for diseases, new research finds 2Even geckos can lose their grip 2
... 27 Warner Chilcott Limited (Nasdaq: WCRX ... Inc. has submitted a New Drug Application for WC ... and Drug Administration. About Warner Chilcott ... currently focused on the women,s healthcare and dermatology segments ...
... Record and A Year,s Supply of Breathalicious ... Sweet at the White HouseLOS ANGELES, March ... Bulletin Board: FVRL), which through its wholly-owned ... consumer-controlled Personal Health Records ("PHRs") ( www.mymedicalrecords.com ...
... to stockholders through liquidationA decisive victory for stockholder ... L.P. ("BVF"), today announced that stockholders of Avigen ... remove the existing Board of Directors of Avigen ... took place earlier today at the special meeting ...
Cached Biology Technology:Warner Chilcott Announces NDA Submission for Low Dose Oral Contraceptive 2Warner Chilcott Announces NDA Submission for Low Dose Oral Contraceptive 3MMR and Dancing Paws to Participate in Joint Sales Effort to Provide Personal Health Records for Pets 2MMR and Dancing Paws to Participate in Joint Sales Effort to Provide Personal Health Records for Pets 3MMR and Dancing Paws to Participate in Joint Sales Effort to Provide Personal Health Records for Pets 4Biotechnology Value Fund, L.P. Announces Overwhelming Support to Remove the Board of Directors of Avigen, Inc. at Special Meeting of Stockholders 2
... II xi cell, 16 cm, is used for ... proteins in agarose gels. The cell is supplied ... central cooling core with gaskets, lower buffer chamber, ... 4 sandwich clamps, upper buffer dam, casting stand ...
CleanCut agarose is used to prepare genomic DNA plugs for use in pulsed field gel electrophoresis (PFGE) applications. Supplied as a 12 ml solution of 2% agarose....
...
... uses the Adept CE 4100 high pressure dual ... dual wavelength detector for added flexibility. ... software and interface unit, CE 4901., The CE ... also be used with Windows 98 and 2000, ...
Biology Products: