Navigation Links
'Normal' cells far from cancer give nanosignals of trouble
Date:7/7/2009

A new Northwestern University-led study of human colon, pancreatic and lung cells is the first to report that cancer cells and their non-cancerous cell neighbors, although quite different under the microscope, share very similar structural abnormalities on the nanoscale level.

The findings, obtained using an optical technique that can detect features as small as 20 nanometers, validate the "field effect," a biological phenomenon in which cells located some distance from a malignant or premalignant tumor undergo molecular and other kinds of abnormal changes.

The most striking findings were that these nanoscale alterations occurred at some distance from the tumor and, importantly, could be identified by assessing more easily accessible tissue, such as the cheek for lung cancer detection.

The partial wave spectroscopy (PWS) technique, once optimized, could be used to detect cell abnormalities early and help physicians assess who might be at risk for developing cancer. Like a pap smear of the cervix, a simple brushing of cells is all that is needed to get the specimen required for testing.

Using PWS, the researchers made another important discovery: the abnormalities found in the nanoarchitecture of the colon cells are the same abnormalities as those found in the pancreas and lung, illustrating commonality across three very different organs.

The results are published online by the journal Cancer Research. Authors of the paper include researchers from Northwestern and NorthShore University HealthSystem.

"Our data provide a strong argument that these nanoscale changes are general phenomena in carcinogenesis and occur early in the process," says Vadim Backman, professor of biomedical engineering at the McCormick School of Engineering and Applied Science and the paper's senior author. "These changes occur not only in cancer cells but in cells far from the tumor site and are the same in at least three differ
'/>"/>

Contact: Megan Fellman
fellman@northwestern.edu
847-491-3115
Northwestern University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Abnormal fat metabolism underlies heart problems in diabetic patients
2. Diverse genetic abnormalities lead to NF-κB activation in multiple myeloma
3. Grant supports study of abnormal ring-shaped chromosomes
4. Study identifies pathway required for normal reproductive development
5. Intravenous gene therapy protects normal tissue of mice during whole-body radiation
6. Using nanotechnology, UCLA researchers discover cancer cells feel much softer than normal cells
7. Study examines genetic defects linked to body abnormalities in patients with childhood cancer
8. New study points to agriculture in frog sexual abnormalities
9. Normal-looking sperm may have serious damage; scientists urge more care in selection
10. Obese men have less semen, more sperm abnormalities, and should lose weight before trying for a baby
11. Largest study of its kind implicates gene abnormalities in bipolar disorder
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... Cancer Institute (HCI) at the University of Utah have ... encodes BCR-ABL, the unregulated enzyme driving the blood cancer ... Society, nearly 6,000 new cases of CML will be ... tyrosine kinase inhibitors (TKIs), target BCR-ABL and are effective ... but control it in a way that allows patients ...
(Date:8/20/2014)... Using population-based screening outcomes of approximately 3 million ... four researchers at the University of Massachusetts Medical School, ... (SCID) can be successfully implemented across public health newborn ... in the Aug. 20 issue of the Journal ... showed the rate of SCID in newborns is higher ...
(Date:8/20/2014)... of sunscreen and seawater signals a relaxing trip to ... idyllic beach vacation comes with an environmental hitch. When ... sea, they can become toxic to some of the ... many other marine animals. Their study appears in the ... Antonio Tovar-Sanchez and David Snchez-Quiles point out that other ...
Breaking Biology News(10 mins):Blueprint for next generation of chronic myeloid leukemia treatment 2Newborn screening expansion offers early diagnosis and treatment to infants with SCID 2Newborn screening expansion offers early diagnosis and treatment to infants with SCID 3
... TORONTO, ON Researchers from the University of Toronto and ... the genes in the fungus that causes Dutch Elm Disease. ... 30 million DNA letters for the fungus Ophiostoma ulmi ... online journal BMC Genomics , could help scientists figure ...
... recently voted to scrap the controversial discards policy, which ... fish waste back into the sea because they have ... could have a negative impact on some seabirds, which ... are increasingly reliant on their discards., But they say ...
... syndrome who wonder if stress aggravates their intestinal disorder, a ... all in their head. Researchers revealed that while ... and induces the intestinal inflammation that often leads to severe ... Stress has a way of suppressing an important component ...
Cached Biology News:Discards ban could impact seabird populations 2Study: Probiotics reduce stress-induced intestinal flare-ups 2
(Date:8/21/2014)... HONG KONG , Aug. 21, 2014  China Cord ... today announced its plan to release financial results for ... August 28, 2014, after market close in the US.  ... call at 8:00 a.m. ET on Friday, August 29, ... brief overview of the Company,s recent developments, followed by ...
(Date:8/21/2014)... St. Louis, MO (PRWEB) August 21, 2014 ... premier, full service biopharmaceutical contract development and manufacturing ... selected by Progenics Pharmaceuticals, Inc., an oncology company ... targeting and treating cancer, to manufacture the anti-prostate ... Progenics’ PSMA ADC product candidate. Under the ...
(Date:8/20/2014)... An analysis of patented university inventions licensed to ... path to commercialization. To open these roadblocks, the ... results during the discovery stage could lead to ... are frequently derived from discoveries made in university ... well known during clinical trials, which have a ...
(Date:8/20/2014)... California (PRWEB) August 20, 2014 ... develop and apply the most complete climate and ... and demanding climate change issues. , Eight national ... forces with the National Center for Atmospheric Research, ... the new effort. Other participating national laboratories include ...
Breaking Biology Technology:China Cord Blood Corporation to Report First Quarter of Fiscal 2015 Financial Results 2Gallus Enters Agreement with Progenics Pharmaceuticals, Inc. for Manufacture of Anti-PSMA Monoclonal Antibody 2Gallus Enters Agreement with Progenics Pharmaceuticals, Inc. for Manufacture of Anti-PSMA Monoclonal Antibody 3Early bottlenecks in developing biopharmaceutical products delay commercialization 2Early bottlenecks in developing biopharmaceutical products delay commercialization 3New Project Is the ACME of Addressing Climate Change 2New Project Is the ACME of Addressing Climate Change 3
... ST. LOUIS, May 16 Stereotaxis, Inc. (Nasdaq:,STXS), ... Officer, will,present at the Seventh Annual JMP Securities ... 2008 at 12:00 p.m. Pacific Time., Attendance ... audio,presentation will be webcast live and remain available ...
... shown that they can use a red blood cell ... , "It turns around the rules of nanotechnology, by ... assistant professor in the Department of Biomedical Engineering at ... student Chawin Ounkomol. , An atomic force microscope uses ...
... esophagus eliminated in 90 percent ... ... Inc., the,global technology leader for treating precancerous conditions of the,digestive tract, ... study were free of the highest-risk of Barrett,s,esophagus after having a ...
Cached Biology Technology:New Study Reports That Ablative Therapy With HALO360 Device Effectively Treats Highest-Risk Category of Barrett's Esophagus 2New Study Reports That Ablative Therapy With HALO360 Device Effectively Treats Highest-Risk Category of Barrett's Esophagus 3
... sealed isolation chamber provides a safe, ... sterile pharmaceuticals, in accord with USP-797 ... 100 (ISO 5) cleanliness conditions in ... IV rod and tilt-up front panel ...
... siRNA Tracker Intracellular Localization Kit with ... forward approach to directly label and ... an efficient yet non-destructive manner, for ... and functional inhibition of target gene ...
... The Label IT siRNA Tracker Intracellular ... provides a straight forward approach to ... your design, in an efficient yet ... experiments. Subcellular localization and functional inhibition ...
Selective media for Salmonella...
Biology Products: