Navigation Links
Noninvasive advanced image analysis could lead to better patient care

PHOENIX, Ariz. July 2, 2014 Lung cancer patients could receive more precise treatment, and their progress could be better tracked, using a new high-tech method of non-invasive medical imaging analysis, according to a study published today by the journal PLOS ONE.

Genetic changes increasingly are recognized as driving cancer development. But obtaining evidence of these changes usually requires a biopsy, which can be problematic for sensitive regions of the body such as the lungs.

Based on a review of 48 patients with non-small cell lung cancer (NSCLC), the study found that by scanning their tumor cells using "quantitative computed tomography based texture analysis" (QTA), researchers could determine with nearly 90 percent accuracy whether the patient's tumor had a cancer-causing K-ras gene mutation.

The study was led by investigators at the Translational Genomics Research Institute (TGen), the Virginia G. Piper Cancer Center at Scottsdale Healthcare, and Cancer Treatment Centers of America (CTCA).

NSCLC represents more than 85 percent of all lung cancers, which will kill an estimated 159,000 Americans this year, making it the leading cause of cancer-related death. It has a five-year survival rate less than 10 percent.

QTA was shown to be an accurate and non-invasive alternative to surgical biopsy and other invasive means of collecting and analyzing biological samples, the study said. This method of making genomic distinctions may help physicians determine the best type of treatment to administer to each patient.

"The ability to rapidly and non-invasively characterize NSCLC tumors would be a great asset to clinical oncologists," said Dr. Glen Weiss, the study's lead author, Director of Clinical Research and Medical Oncologist at Cancer Treatment Centers of America's Western Regional Medical Center in Phoenix, and a Clinical Associate Professor in TGen's Cancer and Cell Biology Division.

"QTA applied to molecularly defined NSCLC cases may have a broader application to precision medicine by offering a non-invasive way of identifying the best therapies for each patient," said Dr. Weiss.

Dr. Ronald Korn, Medical Director of Scottsdale Healthcare's Virginia G. Piper Cancer Center and the study's senior author, described QTA as a substantial step forward in the use of medical imaging: "Non-invasive characterization of a tumor's molecular features could enhance treatment management. Non-invasive QTA can differentiate the presence of K-ras mutation from pan-wildtype NSCLC."

Dr. Korn also is CEO and Medical Director of Imaging Endpoints, a leading imaging core lab that provides centralized image handling and advanced image interpretations for clinical trials. Through Scottsdale Healthcare Research Institute, and in collaboration with Imaging Endpoints Core Lab, this team has developed one of the only global radiology research laboratories that specializes in rapid detection and assessment of response (also known as the RADAR program).

"Although, more studies are needed to move our RADAR program forward towards routine medical use, our core lab remains focused upon characterizing tumors non-invasively through imaging and then using these technologies to help determine, as soon as possible, whether cancer treatments are working, sometimes within days to weeks after the start of therapy" said Dr. Korn.

Dr. Weiss said future studies using QTA also could help identify other genomic sub-types of NSCLC.


Contact: Steve Yozwiak
The Translational Genomics Research Institute

Related biology news :

1. New clinical trial explores novel noninvasive colon cancer screening test
2. New study evaluates noninvasive technology to determine heart disease
3. Biomarker identification may lead to new noninvasive test for colorectal cancer detection
4. Novel noninvasive therapy prevents breast cancer formation in mice
5. Noninvasive brain control
6. Tokai Pharmaceuticals galeterone well-tolerated in patients with advanced prostate cancer
7. New analysis helps guide use of erlotinib in advanced non-small cell lung cancer
8. MARC travel awards announced for the AAI 2012 Advanced Course in Immunology
9. Advanced Photon Source and Canadian Light Source strengthen ties
10. Adoption of advanced techniques could propel crop improvement
11. Advanced Membrane Technology V Conference
Post Your Comments:
(Date:11/19/2015)... VIEW, Calif. , Nov. 19, 2015  Based ... market, Frost & Sullivan recognizes BIO-key with the 2015 ... Leadership. Each year, Frost & Sullivan presents this award ... product line catering to the needs of the market ... the product line meets and expands on customer base ...
(Date:11/18/2015)... New York , November 18, 2015 ... Market Research has published a new market report titled ... Growth, Trends, and Forecast, 2015 - 2021. According to the ... in 2014 and is anticipated to reach US$29.1 bn ... to 2021. North America ...
(Date:11/17/2015)... LIVERMORE, Calif. , Nov. 17, 2015  Vigilant ... has joined its Board of Directors. ... Vigilant,s Board after recently retiring from the partnership at ... owning 107 companies with over $140 Billion in revenue.  ... performance improvement across all the TPG companies, from 1997 ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... ... , ... The United States Golf Association (USGA) today announced Dr. Bruce Clarke, ... annually since 1961, the USGA Green Section Award recognizes an individual’s distinguished service to ... Clarke, of Iselin, N.J., is an extension specialist of turfgrass pathology in the department ...
(Date:11/24/2015)... Mass. (PRWEB) , ... November 24, 2015 , ... ... to maintain healthy metabolism. But unless it is bound to proteins, copper is ... of Health (NIH), researchers at Worcester Polytechnic Institute (WPI) will conduct a systematic ...
(Date:11/24/2015)... , November 24, 2015 ... new market research report "Oligonucleotide Synthesis Market by Product ... (PCR, Gene Synthesis, Diagnostic, DNA, RNAi), End-User (Research, Pharmaceutical ... published by MarketsandMarkets, the market is expected to reach ... in 2015, at a CAGR of 10.1% during the ...
(Date:11/24/2015)... York , November 24, 2015 ... a recent market research report released by Transparency Market ... to expand at a CAGR of 17.5% during the ... Prenatal Testing Market - Global Industry Analysis, Size, Volume, ... the global non-invasive prenatal testing market to reach a ...
Breaking Biology Technology: