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Noninvasive MR imaging of blood vessel growth in tumors using nanosized contrast agents
Date:7/23/2010

eatly improved MRI sensitivity over conventional small molecular agents. The nanoprobe surface was functionalized with integrins that are a cyclic peptide that can specifically bind to overexpressed on the tumor endothelial cells. The nanoprobes also had a fluorescent moiety used for the validation of targeted delivery to the tumor endothelial cells. Studies in cancer cells validated the increased uptake of nanoprobes compared to non-targeted-nanoparticles. In collaboration with Dr. Masaya Takahashi and coworkers in the Advanced Imaging Research Center at UT Southwestern Medical Center, the research team employed a 3D high resolution acquisition method to visualize the accumulation of the micelle nanoprobes in tumors.

Dr. Gao said "Conventional image analysis of angiogenesis relies on the evaluation of 'hot spot' densities in 2D images. The 3D high resolution method allowed for the connection of the isolated 'hot spots' in 2D slices into 3D network structures, which greatly improves the accuracy of vessel identification and quantification."

In preclinical animal tumor models, MR imaging of the targeted contrast probes yielded vascularized network structures in 3D tumor images. The enhanced visualization allowed for a more accurate quantification of tumor angiogenesis. The results showed significant increase of contrast specificity of angiogenic vessels by the targeted nanoprobes over non-targeted micelles. These targeted nanoprobes may provide a useful contrast probe design for the clinical diagnosis of tumor angiogenesis.

Steven R. Goodman, Editor-in-Chief of Experimental Biology and Medicine, said "Kessinger et al working at the interface of nanotechnology, material science, and the clinical imaging modality MRI have created a nanosized probe capable of noninvasively visualizing and quantifying the blood vessel growth in tumors in a preclinical model. This should be an important tool for clinical observation of tumor angiogene
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Contact: Dr. Jinming Gao
jinming.gao@utsouthwestern.edu
214-645-6370
Society for Experimental Biology and Medicine
Source:Eurekalert

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