Navigation Links
Noninvasive MR imaging of blood vessel growth in tumors using nanosized contrast agents
Date:7/23/2010

eatly improved MRI sensitivity over conventional small molecular agents. The nanoprobe surface was functionalized with integrins that are a cyclic peptide that can specifically bind to overexpressed on the tumor endothelial cells. The nanoprobes also had a fluorescent moiety used for the validation of targeted delivery to the tumor endothelial cells. Studies in cancer cells validated the increased uptake of nanoprobes compared to non-targeted-nanoparticles. In collaboration with Dr. Masaya Takahashi and coworkers in the Advanced Imaging Research Center at UT Southwestern Medical Center, the research team employed a 3D high resolution acquisition method to visualize the accumulation of the micelle nanoprobes in tumors.

Dr. Gao said "Conventional image analysis of angiogenesis relies on the evaluation of 'hot spot' densities in 2D images. The 3D high resolution method allowed for the connection of the isolated 'hot spots' in 2D slices into 3D network structures, which greatly improves the accuracy of vessel identification and quantification."

In preclinical animal tumor models, MR imaging of the targeted contrast probes yielded vascularized network structures in 3D tumor images. The enhanced visualization allowed for a more accurate quantification of tumor angiogenesis. The results showed significant increase of contrast specificity of angiogenic vessels by the targeted nanoprobes over non-targeted micelles. These targeted nanoprobes may provide a useful contrast probe design for the clinical diagnosis of tumor angiogenesis.

Steven R. Goodman, Editor-in-Chief of Experimental Biology and Medicine, said "Kessinger et al working at the interface of nanotechnology, material science, and the clinical imaging modality MRI have created a nanosized probe capable of noninvasively visualizing and quantifying the blood vessel growth in tumors in a preclinical model. This should be an important tool for clinical observation of tumor angiogene
'/>"/>

Contact: Dr. Jinming Gao
jinming.gao@utsouthwestern.edu
214-645-6370
Society for Experimental Biology and Medicine
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Frost & Sullivan Recognizes AOptix Technologies for its Pioneering Contribution to Security through Noninvasive Biometrics
2. Star Trek-like technology offers noninvasive monitor for patients and athletes
3. Humble garden pea helps Kew scientists develop cool, noninvasive diagnostic test of seed quality
4. Cheap, simple, noninvasive blood test may replace invasive diagnostic techniques in early pregnancy
5. SNM releases new fact sheet on breast cancer and molecular imaging
6. Cheskin Added Value EVP Lee Shupp Discusses Evolving Dynamics of Consumers and Imaging Tech at 6Sight
7. MU brain imaging center provides research for autism, schizophrenia and Parkinsons disease
8. Similarities in imaging the human body, Earths crust focus of conference at UH
9. UNC expands brain imaging study of infants at risk for autism
10. Studies on imaging and tracking transplanted cells
11. Fattysaurus or thinnysaurus? How dinosaurs measure up with laser imaging
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... SHENZHEN , Chine, 31 juillet 2015 /PRNewswire/ ... (ICG-10, www.icg-10.org ) sera organisée par le ... Shenzhen en Chine. ... année. Depuis son inauguration en 2006, l,ICG est ... influentes dans le domaine des « omiques » et c,est ...
(Date:7/31/2015)... Die 10. internationale Konferenz zu Genomik (ICG-10, ... vom 22. bis 25. Oktober 2015 in ... Die Konferenz feiert in diesem Jahr ihr ... ICG weltweit zu einem der einflussreichsten jährlichen Treffen ... dynamischsten, enthusiastischsten und angenehmsten wissenschaftlichen Zusammentreffen. ...
(Date:7/31/2015)... The 10 th International Conference on Genomics ... 22-25, 2015, in Shenzhen , ... 10 th anniversary this year. Since its inauguration in ... annual meetings in the ,omics, fields, and is one of ... ICG-10 focuses on recent breakthroughs and advances in ,omics, ...
Breaking Biology News(10 mins):La 10e International Conference on Genomics (ICG-10) doit s'ouvrir en octobre 2La 10e International Conference on Genomics (ICG-10) doit s'ouvrir en octobre 3Die 10. internationale Konferenz zu Genomik (ICG-10) beginnt im Oktober 2Die 10. internationale Konferenz zu Genomik (ICG-10) beginnt im Oktober 3The 10th International Conference on Genomics (ICG-10) to Open in October 2
... Colorado (CU) has signed exclusive, worldwide licensing and ... Ltd to develop an enzyme replacement therapy for ... metabolic disease that is often fatal at a ... and includes sponsored-research funding by OT to continue ...
... during a record-setting expedition have yielded new insights about ... the cold, dark, and highly pressurized habitats of the ... Natalya Gallo of Scripps Institution of Oceanography at UC ... CHALLENGE expedition, a project led by James Cameron in ...
... virologist Masahiro Niikura and his doctoral student Nicole Bance are ... new class of molecular compounds capable of killing the influenza ... of a good thing can be a killer, the scientists ... is key to how influenza replicates and spreads. , ...
Cached Biology News:University of Colorado and Orphan Technologies sign agreement 2University of Colorado and Orphan Technologies sign agreement 3Vibrant mix of marine life found at extreme ocean depths, Scripps analysis reveals 2Vibrant mix of marine life found at extreme ocean depths, Scripps analysis reveals 3Influenza study: Meet virus' new enemy 2
(Date:8/27/2015)... , Aug. 27, 2015  Neogen Corporation (NASDAQ: ... stock of United Kingdom -based Lab ... culture media and diagnostic systems. Lab ... a leading provider of microbial testing and diagnostic products ... markets. The company currently sells into more than 70 ...
(Date:8/27/2015)... , Aug. 27, 2015 HUYA Bioscience International ... of the Japan Society of HTLV-1, held this week ... The purpose of the Society is to promote research ... development of medical technology and research related to these ... "HUYA is proud to support this prestigious ...
(Date:8/27/2015)... ... August 27, 2015 , ... Proove Biosciences, a ... the relationship of genetics and hypertension at the International Academy of Cardiology ... British Columbia, Canada. The event, which boasts an extensive overview of the latest ...
(Date:8/26/2015)... -- The Diabetes Research Institute (DRI), a Center of ... of Medicine, announced today that the first patient ... first time a novel transplant technique for insulin-producing ... I/II study builds upon decades of progress in ... step toward the development of the DRI BioHub, ...
Breaking Biology Technology:Neogen acquires U.K.-based Lab M Holdings 2HUYA Bioscience International Sponsors Japan Society Of HTLV-1 Annual Meeting 2HUYA Bioscience International Sponsors Japan Society Of HTLV-1 Annual Meeting 3HUYA Bioscience International Sponsors Japan Society Of HTLV-1 Annual Meeting 4Proove Biosciences Presents Ground-Breaking Data on Genetics and Heart Disease at 20th World Congress on Heart Disease 2Proove Biosciences Presents Ground-Breaking Data on Genetics and Heart Disease at 20th World Congress on Heart Disease 3Diabetes Research Institute Successfully Transplants First Patient In Pilot BioHub Trial 2Diabetes Research Institute Successfully Transplants First Patient In Pilot BioHub Trial 3Diabetes Research Institute Successfully Transplants First Patient In Pilot BioHub Trial 4
... , BEIJING, June 8 /PRNewswire-Asia/ -- Sinovac ... provider of vaccines in China, announced today that it,begins the production ... received from US CDC and was delivered to the company on ... Chairman, President and CEO of Sinovac, commented, ,In,the midst of a ...
... Offering AccuVein,s AV300 Hand-Held Vein Illumination Device to Membership , ... AccuVein LLC today announced a three year agreement with ... hand-held, non-contact vein illumination device to its members. The ... skin revealing vein position to help the healthcare professional locate ...
... Pasteuria Bioscience announced that it has received registration from ... usgae . This is a critical step towards the ... prevalent in soil that have long been recognized as promising ... , "We,re very pleased to receive this EPA registration," said ...
Cached Biology Technology:Sinovac Begins the Production of Influenza A (H1N1) Vaccine 2Sinovac Begins the Production of Influenza A (H1N1) Vaccine 3AccuVein Inks National Three-Year Group Purchasing Deal With Amerinet 2Pasteuria Bioscience Receives EPA Registration for Nematode Control 2
capacity 250 mL...
... to MSY2/YBOX2 ( Abpromise for ... Antigen: Synthetic peptide derived from ... of human YBX2. (Note: the ... Entrez ...
... CLS number is a ... to easily match Cornings ... no availability yet, please ... Sigma-Aldrich number (Z35,347-7) or ...
Standard Fluka For microscopy (Bact., Hist.)...
Biology Products: