Navigation Links
Noninvasive MR imaging of blood vessel growth in tumors using nanosized contrast agents
Date:7/23/2010

This release is also available in Chinese.

Formation of new blood vessels, also known as angiogenesis, is crucial for sustained tumor growth and cancer metastasis. Recently, clinically available therapies to suppress the growth of these vessels have been available to improve patient survival in some cancer types. Accurate detection and quantification of blood vessel growth using nonsurgical methods would greatly complement current therapies and allow physicians to quickly assess treatment regimens and adjust them as necessary. In the work published in the August issue of Experimental Biology and Medicine, Kessinger and coworkers have incorporated nanotechnology, material science, and the clinical imaging modality MRI, to create a nanosized probe capable of noninvasively visualizing and quantifying the blood vessel growth in tumors in a preclinical model. The work was carried out by Chase Kessinger, as part of his PhD thesis in cancer molecular imaging, working together with Jinming Gao and other colleagues, at the University of Texas Southwestern Medical Center at Dallas.

Dr. Gao stated "Imaging tumor angiogenesis is important in early detection, tumor stratification and post-therapy assessment of antiangiogenic drugs. Current clinical modality for angiogenesis imaging utilizes dynamic contrast enhancement MRI by small molecular contrast agents. The method is based on the measurement of permeability of the contrast probes in well-established solid tumors and is not very specific to detect the early on-set of vessel formation. The dual functional nanoprobes aim to image angiogenesis-specific tumor markers that are overly expressed in the tumor vasculature during the early phase of angiogenesis."

Together, the research team relied on nanotechnology and established super paramagnetic micellar nanoprobes (50-70 nm in diameter) with greatly improved MRI sensitivity over conventional small molecular agents. The nanoprobe surface was functionalized with integrins that are a cyclic peptide that can specifically bind to overexpressed on the tumor endothelial cells. The nanoprobes also had a fluorescent moiety used for the validation of targeted delivery to the tumor endothelial cells. Studies in cancer cells validated the increased uptake of nanoprobes compared to non-targeted-nanoparticles. In collaboration with Dr. Masaya Takahashi and coworkers in the Advanced Imaging Research Center at UT Southwestern Medical Center, the research team employed a 3D high resolution acquisition method to visualize the accumulation of the micelle nanoprobes in tumors.

Dr. Gao said "Conventional image analysis of angiogenesis relies on the evaluation of 'hot spot' densities in 2D images. The 3D high resolution method allowed for the connection of the isolated 'hot spots' in 2D slices into 3D network structures, which greatly improves the accuracy of vessel identification and quantification."

In preclinical animal tumor models, MR imaging of the targeted contrast probes yielded vascularized network structures in 3D tumor images. The enhanced visualization allowed for a more accurate quantification of tumor angiogenesis. The results showed significant increase of contrast specificity of angiogenic vessels by the targeted nanoprobes over non-targeted micelles. These targeted nanoprobes may provide a useful contrast probe design for the clinical diagnosis of tumor angiogenesis.

Steven R. Goodman, Editor-in-Chief of Experimental Biology and Medicine, said "Kessinger et al working at the interface of nanotechnology, material science, and the clinical imaging modality MRI have created a nanosized probe capable of noninvasively visualizing and quantifying the blood vessel growth in tumors in a preclinical model. This should be an important tool for clinical observation of tumor angiogenesis".


'/>"/>

Contact: Dr. Jinming Gao
jinming.gao@utsouthwestern.edu
214-645-6370
Society for Experimental Biology and Medicine
Source:Eurekalert

Related biology news :

1. Frost & Sullivan Recognizes AOptix Technologies for its Pioneering Contribution to Security through Noninvasive Biometrics
2. Star Trek-like technology offers noninvasive monitor for patients and athletes
3. Humble garden pea helps Kew scientists develop cool, noninvasive diagnostic test of seed quality
4. Cheap, simple, noninvasive blood test may replace invasive diagnostic techniques in early pregnancy
5. SNM releases new fact sheet on breast cancer and molecular imaging
6. Cheskin Added Value EVP Lee Shupp Discusses Evolving Dynamics of Consumers and Imaging Tech at 6Sight
7. MU brain imaging center provides research for autism, schizophrenia and Parkinsons disease
8. Similarities in imaging the human body, Earths crust focus of conference at UH
9. UNC expands brain imaging study of infants at risk for autism
10. Studies on imaging and tracking transplanted cells
11. Fattysaurus or thinnysaurus? How dinosaurs measure up with laser imaging
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/30/2017)... KONG , March 30, 2017 The ... a system for three-dimensional (3D) fingerprint identification by adopting ground breaking ... into a new realm of speed and accuracy for use in ... at an affordable cost. ... ...
(Date:3/28/2017)... India , March 28, 2017 ... IP, Biometrics), Hardware (Camera, Monitors, Servers, Storage Devices), Software ... Vertical, and Region - Global Forecast to 2022", published ... Billion in 2016 and is projected to reach USD ... between 2017 and 2022. The base year considered for ...
(Date:3/24/2017)... 24, 2017 Research and Markets has announced ... Analysis & Trends - Industry Forecast to 2025" report to ... The ... a CAGR of around 15.1% over the next decade to reach ... analyzes the market estimates and forecasts for all the given segments ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... LAGUNA HILLS, Calif. , Oct. 11, 2017 /PRNewswire/ ... London (ICR) and University of ... tool to risk-stratify patients with multiple myeloma (MM), in a ... . The University of Leeds is ... Myeloma UK, and ICR will perform the testing services to ...
(Date:10/11/2017)... , ... October 11, 2017 , ... ... the implantation and pregnancy rates in frozen and fresh in vitro fertilization ... progesterone and maternal age to IVF success. , After comparing the results from ...
(Date:10/10/2017)... ... October 10, 2017 , ... San Diego-based team building and cooking events ... announced today. The bold new look is part of a transformation to increase ... a significant growth period. , It will also expand its service offering from its ...
(Date:10/10/2017)... ... October 10, 2017 , ... ... FirstHand program has won a US2020 STEM Mentoring Award. Representatives of the FirstHand ... Excellence in Volunteer Experience from US2020. , US2020’s mission is to change the ...
Breaking Biology Technology: