Navigation Links
Nonagenarian researcher petitions FDA to ban trans fats

CHAMPAIGN, Ill. "I request to ban trans fats from the American diet."

Thus begins a 3,000-word petition to the Food and Drug Administration, the work of a man on a dogged, decades-old crusade to eradicate trans fats from food.

Fred Kummerow, a 94-year-old University of Illinois veterinary biosciences professor emeritus who still conducts research on the health effects of trans fats in the diet, filed the petition with the FDA last month. The petition is now posted on the FDA Web site, and public comments are invited. (See below for information on viewing the petition and making a comment.)

"Everybody should read my petition because it will scare the hell out of them," Kummerow said.

Trans fats contribute to the two main causes of heart disease: blood clots in the coronary arteries that can lead to sudden death from a heart attack, and atherosclerosis, the buildup of plaque in the arteries that interferes with blood flow, he said. Trans fats are also known to increase low-density lipoproteins (LDLs) in the blood and to spur inflammation, both of which contribute to heart disease.

Trans fats displace the essential fatty acids linoleic acid (omega-6) and linolenic acid (omega-3), which the body needs for a variety of functions. Kummerow's own research, published last month in the journal Atherosclerosis, found that trans fats also interfere with the function of a key enzyme essential to blood flow regulation.

An earlier study from Kummerow's lab found that pregnant sows fed a diet that included trans fats passed significant quantities of the trans fats to their offspring during nursing. The piglets' plasma levels of trans fats increased from 5 percent three days after birth to 15.3 percent at 6 weeks of age.

Kummerow believes the FDA's requirement (begun in 2006) that trans fats be included on food labels is inadequate and misleading. Anything less than one-half gram of trans fats per serving can be listed as zero grams. This means that people are getting the mistaken impression that their food is trans fat-free, he said.

Although Kummerow began publishing on trans fats in 1957, his efforts against trans fats in food began in earnest in 1968, when he urged the American Heart Association to ask the Institute of Shortening and Edible Oils to have its members decrease the amount of trans fatty acids in shortenings and margarines, replacing them with essential fatty acids.

"Even then, there was strong evidence that trans fatty acids increased plasma cholesterol levels," Kummerow said.

The food oil industry reluctantly agreed to lower the trans fatty acid content and increase essential fatty acids in its products. That change coincided with a dramatic decline in coronary heart disease mortality after 1968. Kummerow believes the decline in the dietary intake of trans fats and the increase in linoleic acid could explain at least part of the reduction in mortality due to heart disease.

To reinforce his message, Kummerow keeps in his lab a sample of human arteries that are clogged with atherosclerotic plaque. Another unfortunate characteristic of trans fats is that they cause cells to increase calcium in the blood, which builds up in and narrows the arteries, the main symptom of atherosclerosis.

Atherosclerosis makes the arteries "look like old scrub boards," Kummerow said. "They look corrugated. This corrugation builds up to the point where it will stop blood flow."

Kummerow's petition was filed Aug. 7, 2009. The FDA has 180 days to respond.

"According to American Heart Association data, nearly 2,400 Americans die of heart disease each day," Kummerow said. "This statistic shows the importance of a quick response."


Contact: Diana Yates
University of Illinois at Urbana-Champaign

Related biology news :

1. UT Southwestern researchers examine mechanisms that help cancer cells proliferate
2. Marine biomedicine researchers decode structure of promising sea compound
3. Researchers report gene associated with language, speech and reading disorders
4. Bats use love songs during mating, researchers say
5. Idaho researchers win grant to explore DNA frontier
6. Case Western Reserve University researcher demonstrates that messenger RNA are lost in translation
7. UCSF researchers identify 2 key pathways in adaptive response
8. NASA researcher nets first measure of Africas coastal forests
9. Disrupting a destructive duo: U of T Mississauga researchers inhibit cancer proteins
10. Researchers boost production of biofuel that could replace gasoline
11. Researcher says microchannels could advance tissue engineering methods
Post Your Comments:
Related Image:
Nonagenarian researcher petitions FDA to ban trans fats
(Date:11/18/2015)... York , November 18, 2015 ... Research has published a new market report titled  Gesture ... Trends, and Forecast, 2015 - 2021. According to the report, ... 2014 and is anticipated to reach US$29.1 bn by ... 2021. North America dominated ...
(Date:11/17/2015)... 2015 Pressure BioSciences, Inc. (OTCQB: PBIO) ("PBI" ... sale of broadly enabling, pressure cycling technology ("PCT")-based sample ... announced it has received gross proceeds of $745,000 from ... (the "Offering"), increasing the total amount raised to date ... closings are expected in the near future. ...
(Date:11/12/2015)... 11, 2015   Growing need for low-cost, ... has been paving the way for use of ... discrete analytes in clinical, agricultural, environmental, food and ... used in medical applications, however, their adoption is ... to continuous emphasis on improving product quality and ...
Breaking Biology News(10 mins):
(Date:11/25/2015)... 2015 Studies reveal the differences ... and pave the way for more effective treatment for one ...   --> --> ... problems in cats, yet relatively little was understood about the ... have been conducted by researchers from the WALTHAM Centre for ...
(Date:11/25/2015)... IN (PRWEB) , ... November 25, 2015 , ... ... (AMA) and the Organization of Black Aerospace Professionals (OPBAP) has been formalized with ... and other AMA team leaders met with OPBAP leaders Capt. Karl Minter and ...
(Date:11/24/2015)... , Nov. 24, 2015  Asia-Pacific (APAC) ... research organisation (CRO) market. The trend of outsourcing ... lower margins but higher volume share for the ... and scale, however, margins in the CRO industry ... (CRO) Market ( ), finds that ...
(Date:11/24/2015)... , Nov. 24, 2015 /CNW/ - iCo Therapeutics ("iCo" ... reported financial results for the quarter ended September ... in Canadian dollars and presented under International Financial ... States ," said Andrew Rae , ... regarding iCo-008 are not only value enriching for ...
Breaking Biology Technology: