Navigation Links
Non-wovens as scaffolds for artificial tissue
Date:5/13/2009

This release is available in German.

When someone's knee hurts with every step it's a sign that the cartilage has been so badly damaged that the bones rub together when walking. Medical scientists are developing a technique to produce cartilage tissue artificially so that patients with such knee problems can walk free of pain again. The aim is also to make tendons and blood vessels in the laboratory. The research scientists place cells on a porous scaffold material, for example a non-woven made of polymer fibers. The cells can then grow on this frame and form tissue. Whether the cells will grow properly into tissue, however, depends on many factors. For instance, the cells only form cartilage if they are subjected to loads comparable with those in the body. To form cartilage the tissue needs to experience the pressure applied by every step. By contrast, blood vessel tissue needs the pulsation of the blood. The scientists reproduce these loads in the cell culture. When the artificial cartilage is inserted in the patient's knee the supporting scaffold is gradually resorbed and only the cartilage tissue remains.

While it is quite easy to produce npn-wovens from thin polymer fibers, it is difficult to describe these materials experimentally and theoretically. What forces do the cells experience when the non-woven is pulled or when a liquid passes through the fibre network? How do cells penetrate the non-woven? How do liquids permeate the non-woven? Research scientists at the Fraunhofer Institute for Mechanics of Materials IWM in Freiburg and Halle have developed a simulation model which answers these questions and characterizes the fleeces. "The simulation reproduces the mechanical properties of the fleeces and the transport processes the software can therefore also calculate how nutrients are transported to the cells and metabolic products are transported away from the cells when a liquid flows by," explains Dr. Raimund Jaeger, group manager at the IWM. "Understanding these processes can be helpful for cell culture." To produce the model, the research scientists initially studied the mechanical properties of the individual polymer fibers and for this purpose developed a special apparatus. On a silicon chip measuring one square centimeter, the scientists in Halle etched approximately 50 "microtesting machines". They then placed and fastened the fibers over the testing machines. Under the microscope the researchers were able to observe how the fibers behave when they are pulled, how far they stretch and when they snap. As fiber-like structures are frequently encountered in nature and technology, suitable experimental techniques and simulation methods have a wide range of applications.


'/>"/>

Contact: Dr. Raimund Jaeger
raimund.jaeger@iwm.fraunhofer.de
49-761-514-2284
Fraunhofer-Gesellschaft
Source:Eurekalert  

Related biology news :

1. Smart scaffolds may help heal broken hearts
2. Development of an artificial simulator of the nervous system to do research into diseases
3. Red pandas reveal an unexpected (artificial) sweet tooth
4. Artificial cells, simple model for complex structure
5. TECNALIA uses artificial vision to improve recycling of electronic scrap metal
6. Biomedical researchers create artificial human bone marrow in a test tube
7. Scientists identify cell changes leading to impaired artificial kidney function
8. Evolved Machines Selected as a Prime Contractor for DARPA Program to Engineer an Artificial Olfaction System
9. Researchers design artificial cells that could power medical implants
10. Taking the next step toward advanced artificial limbs
11. Complex ocean behavior studied with artificial upwelling
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Non-wovens as scaffolds for artificial tissue
(Date:4/19/2016)... , UAE, April 20, 2016 ... implemented as a compact web-based "all-in-one" system solution for ... biometric fingerprint reader or the door interface with integration ... modern access control systems. The minimal dimensions of the ... readers into the building installations offer considerable freedom of ...
(Date:4/13/2016)... 13, 2016  IMPOWER physicians supporting Medicaid patients in ... new clinical standard in telehealth thanks to a new ... higi platform, IMPOWER patients can routinely track key health ... mass index, and, when they opt in, share them ... to a local retail location at no cost. By ...
(Date:3/23/2016)... , March 23, 2016 ... Interesse erhöhter Sicherheit Gesichts- und Stimmerkennung mit ... Inc. (NASDAQ: MESG ), ein ... dass das Unternehmen mit SpeechPro zusammenarbeitet, um ... der Finanzdienstleistungsbranche, wird die Möglichkeit angeboten, im ...
Breaking Biology News(10 mins):
(Date:5/2/2016)... (PRWEB) , ... May 02, 2016 , ... ... with its clients in mind, the fresh look and added functionality give the ... “Recent years have seen a dynamic shift in agriculture – from precision farming ...
(Date:5/2/2016)... (PRWEB) , ... May 02, 2016 , ... ... to report on the pre-launch success of their revolutionary, veterinarian-designed product for indoor ... to stalk, trap, and play with their food the way nature intended. NoBowls ...
(Date:4/29/2016)... Irvine, CA (PRWEB) , ... April 29, 2016 ... ... research leader in personalized pain medicine, is excited to announce the launch of ... to supporting public health studies, volunteerism, and education to promote the use of ...
(Date:4/29/2016)... , April 29, 2016 ... by Transparency Market Research "Separation Systems for Commercial ... Growth, Trends, and Forecast 2015 - 2023", the ... at US$ 10,665.5 Mn in 2014 and is ... from 2015 to 2023 to reach US$ 19,227.8 ...
Breaking Biology Technology: