Navigation Links
Non-coding DNA implicated in type 2 diabetes
Date:1/12/2014

Variations in non-coding sections of the genome might be important contributors to type 2 diabetes risk, according to a new study.

DNA sequences that don't encode proteins were once dismissed as "junk DNA", but scientists are increasingly discovering that some regions are important for controlling which genes are switched on.

The new study, published in Nature Genetics, is one of the first to show how such regions, called regulatory elements, can influence people's risk of disease.

Type 2 diabetes affects over 300 million people worldwide. Genetic factors have long been known to have an important role in determining a person's risk of type 2 diabetes, alongside other factors such as body weight, diet and age.

Many studies have identified regions of the genome where variations are linked to diabetes risk, but the function of many of these regions is unknown, making it difficult for scientists to glean insights into how and why the disease develops. Only around two per cent of the genome is made up of genes: the sequences that contain code for making proteins. Most of the remainder is shrouded in mystery.

"Non-coding DNA, or junk DNA as it is sometimes known, is the dark matter of the genome. We're only just beginning to unravel what it does," said leading author Professor Jorge Ferrer, a Wellcome Trust Senior Investigator from the Department of Medicine at Imperial College London.

In the new study scientists mapped the regulatory elements that orchestrate gene activity in the cells of the pancreas that produce insulin, a hormone that regulates blood sugar.

In type 2 diabetes, the tissues become less responsive to insulin, resulting in blood sugar levels being too high. Most people can compensate when this happens by producing more insulin, but in people with type 2 diabetes, the pancreas cannot cope with this increased demand.

"The cells that produce insulin appear to be progra
'/>"/>

Contact: Sam Wong
sam.wong@imperial.ac.uk
44-207-594-2198
Imperial College London
Source:Eurekalert

Page: 1 2

Related biology news :

1. Garvan Institute receives grant to research role of long non-coding RNAs in Parkinsons disease
2. A hallmark for the development of testicular tumors found in the aberrant regulation of small non-coding RNA
3. Immune system implicated in prematurity complication
4. Protein involved in nerve-cell migration implicated in spread of brain cancer
5. BROCA sequencing approach evaluates all 24 genes implicated in breast cancer
6. Diabetes Research Institute develops oxygen-generating biomaterial
7. New study shines light on barriers to diabetes care in NYC Bangladeshi community
8. Commonly used diabetes drug may help to prevent primary liver cancer
9. Approach to diabetes self-management too narrow, study suggests
10. Gut microbiota transplantation may prevent development of diabetes and fatty liver disease
11. From feast to famine: A metabolic switch that may help diabetes treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/29/2014)... methods and applications for imaging and manipulation of the ... were the inspiration behind Neurophotonics , a new ... optics and photonics. , The first issue coincides with ... States, and a special section features articles that lay ... impact that optics and photonics will have on advancing ...
(Date:7/29/2014)... you,ve ever ordered the wrong food at a restaurant, don,t ... have less to do with what you want and more ... analyzing 217 menus and the selections of over 300 diners, ... Journal of Hospitality Management showed that when it comes ... what you see on the menu and how you imagine ...
(Date:7/29/2014)... the edge of science, Clment Vidal takes on big ... the End: Does our universe have a beginning and ... in the universe? What is the role of intelligent ... and committed to philosophical rigor, the book presents an ... not an accident, but may well be the key ...
Breaking Biology News(10 mins):SPIE launches Neurophotonics journal with special section on BRAIN Initiative 2SPIE launches Neurophotonics journal with special section on BRAIN Initiative 3Menu secrets that can make you slim by design 2Book: 'The Beginning and the End' 2
... The naked mole rat, a curiously strange, hairless rodent, ... Scientists at The University of Texas Health Science Center San ... explore this mystery. On May 2 a Barshop Institute ... protein disposal called proteasome assemblies differ in composition ...
... UPTON, NY Hydrogen gas offers one of ... fuels. But traditional methods of producing pure hydrogen face ... releasing harmful carbon dioxide into the atmosphere or requiring ... Now, scientists at the U.S. Department of Energy,s (DOE) ...
... announced today that it is a Grand Challenges Explorations winner, ... Dr. Gregor Reid and his team are the first ... The research project will study the impact of ... on the health outcomes of pregnant women and their children. ...
Cached Biology News:Scientists find differences in naked mole rat's protein disposers 2Low-cost nanosheet catalyst discovered to split hydrogen from water 2Low-cost nanosheet catalyst discovered to split hydrogen from water 3Low-cost nanosheet catalyst discovered to split hydrogen from water 4Lawson recieves Grand Challenges Explorations grant for groundbreaking research 2
(Date:7/30/2014)... 2014 Adding to their already extensive ... special – Buy 2 of any Weighing Boats ... benefit lab technicians looking for durable and reliable weighing ... for multiple applications including weighing liquids, solid, or granulated ... including diamond-shaped, hexagonal, square, aluminum weighing, and standard boats. ...
(Date:7/29/2014)... have hurdled a number of significant technological challenges ... observing technology originally created for the James Webb ... Investigator Harvey Moseley, a scientist at NASA,s Goddard ... that electrostatically actuated microshutter arrays that is, ... are as functional as the current technology,s magnetically ...
(Date:7/29/2014)... Tough, ultralight foam of atom-thick sheets can be made ... invented at Rice University. , In microscopic images, ... with floors and walls that reinforce each other. The ... and walls of graphene oxide that self-assemble with the ... researchers say the foam could find use in structural ...
(Date:7/29/2014)... According to the new research report  "Digital ... Software), Delivery Modes (Web Based/Cloud Based) & Whole Slide ... published by MarketsandMarkets, analyzes and studies the major market ... North America , Europe , ... the World (RoW). Browse 78 market data ...
Breaking Biology Technology:Weighing Boat Promotion Now Available at Pipette.com, Major Pipette Distributor 2Revolutionary microshutter technology hurdles significant challenges 2Revolutionary microshutter technology hurdles significant challenges 3Revolutionary microshutter technology hurdles significant challenges 4Tough foam from tiny sheets 2Digital Pathology Market worth $437 Million by 2018 2Digital Pathology Market worth $437 Million by 2018 3
... Will Raise $1.5 Million to ... Help Fight Chronic Kidney Disease, EL SEGUNDO, Calif., June ... those diagnosed with chronic kidney,disease and failure (CKD), today announced that ... 29, 2008,in Virginia Beach, Va. DaVita KAT Walks Across America(TM) are ...
... Now you see it, soon you might not, ... computer simulations, the researchers have demonstrated an approximate cloaking ... The mathematical proof brings scientists a step closer to ... much more than a theoretical exercise," said Harley Johnson, ...
... a white paper titled “Avanta AC™ Advanced ... Nanopowders” online. This white paper outlines the ... a nanometer scale, as well as the ... Advanced ceramic nanopowders are critical to a ...
Cached Biology Technology:Third Annual DaVita Kidney Disease Awareness Walks to Hit 20 Cities in 2008 2Silicon photonic crystals key to optical cloaking, researchers say 2 SACHEM Launches New Products for High Purity Advanced Ceramic Powders : Avanta AC™ Advanced Ceramics Solutions Offer Unique Advantages over Inorganic Bases in the Manufacture of Advanced Ceramic Nanoparticles 2
96 Well Plate Sterile, RE bottom; consistent medium binding affinity for hydrophobic complexes and proteins....
Thermo Forma provides an array of accessory Racks for the Cryo/CryoPlus 16" Diameter storage system. To maximise inventory capacity a Jumbo Arrowhead configuration is recommended. You may choose betw...
... Console Orbital Shakers combine high durability ... programming power. The patented triple-counterbalanced ... unit to run with heavy out-of-balance ... system reduces contamination. The heavy ...
... orbital shakers combine high durability and capacity ... triple-counterbalanced heavy-duty mechanism prevents vibration, allowing the ... loads. Every other part, from the large ... thick machined aluminum platform is designed to ...
Biology Products: