Navigation Links
'Noise' tunes logic circuit made from virus genes
Date:11/8/2011

In the world of engineering, "noise" random fluctuations from environmental sources such as heat is generally a bad thing. In electronic circuits, it is unavoidable, and as circuits get smaller and smaller, noise has a greater and more detrimental effect on a circuit's performance. Now some scientists are saying: if you can't beat it, use it. Engineers from Arizona State University in Tempe and the Space and Naval Warfare Systems Center (SPAWAR) in San Diego, Calif., are exploiting noise to control the basic element of a computer a logic gate that can be switched back and forth between two different logic functions, such as AND\OR using a genetically engineered system derived from virus DNA. In a paper accepted to the AIP's journal Chaos, the team has demonstrated, theoretically, that by exploiting sources of external noise, they can make the network switch between different logic functions in a stable and reliable way.

The scientists focused on a single-gene network in a bacteriophage λ (lamda). The gene they use regulates the production of a particular protein in the virus. Normally, there are biological reactions that regulate the creation and destruction of this protein; upsetting that balance results in a protein concentration that is either too high or too low. The scientists assigned a "1" to one concentration and a "0" to the other. By manipulating the protein concentration, the team could encode the logic gate input values and obtain the desired output values.

Researchers modeled the system as two potential energy "wells" separated by a hump, corresponding to an energy barrier. In the presence of too much noise, the system never relaxes into one of the two wells, making the output unpredictable. Too little noise, on the other hand, does not provide the boost necessary for the system to reach a high enough protein concentration to overcome the energy barrier; in this case, there is also a high probability that the biological logic gate will fail to achieve its predicted computation. But an optimal amount of noise stabilizes the circuit, causing the system to jump into the "correct well" and stay there. This proof-of-concept work offers the possibility of exploiting noise in biologic circuits instead of regarding it as a laboratory curiosity or a nuisance, the researchers say.


'/>"/>

Contact: Jennifer Lauren Lee
jlee@aip.org
301-209-3099
American Institute of Physics
Source:Eurekalert

Related biology news :

1. Noise pollution negatively affects woodland bird communities, says CU-Boulder study
2. Precise trace gas analysis, without the noise
3. Lone whales shout to overcome noise
4. University of Maryland co-sponsors International Conference on the Effects of Noise on Aquatic Life
5. Noise distracts fish from their dinner
6. Cephalopods experience massive acoustic trauma from noise pollution in the oceans
7. Noise research to combat wind turbine syndrome
8. Unexpected role of noise in spine formation
9. Human genes sing different tunes in different tissues
10. Songbirds tweak their tunes in different ways to cope with clamor
11. NIST tunes metasurface with fluid in new concept for sensing and chemistry
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2016)... , Dec. 20, 2016  As part of its longstanding ... leading personal genetics company, recently released its latest children,s book, ... The book focuses on the topics of inheritance and variation ... Standards (NGSS) taught in elementary school classrooms in the US. ... series by illustrator Ariana Killoran , whose previous book ...
(Date:12/20/2016)... and GENEVA, Dec, 20, 2016   Valencell ... sensor technology, and STMicroelectronics (NYSE: STM), a ... of electronics applications, announced today the launch of ... for biometric wearables that includes ST,s compact ... Valencell,s Benchmark™ biometric sensor system. Together, SensorTile ...
(Date:12/16/2016)... Research and Markets has announced the addition of the "Biometric ... to their offering. ... The biometric vehicle access system market, in terms of value, ... to 2021. The market is estimated to be USD 442.7 Million ... The growth of the biometric vehicle access system market is fueled ...
Breaking Biology News(10 mins):
(Date:1/20/2017)... January 20, 2017 Stock-Callers.com explores ... have influenced the most recent performances of select equities. ... RGLS ), Abeona Therapeutics Inc. (NASDAQ: ... TBPH ), and Sage Therapeutics Inc. (NASDAQ: ... Grand View Research, global Biotech market size is expected to reach $604.40 ...
(Date:1/20/2017)... ... January 20, 2017 , ... ... the next evolution in spinal fusion, the MISquito Percutaneous Pedicle Screw System ... competition, SpineFrontier is focused on technique driven product solutions that provide maximum ...
(Date:1/19/2017)... and HOUSTON , Jan. 19, ... today announced the formation of its Medical/Clinical Advisory ... and industry veterans who enhance the range and ... accelerates development of its novel prenatal diagnostic tests.  ... clinical and strategic guidance for the company,s product ...
(Date:1/19/2017)... ... January 19, 2017 , ... ... solutions for pharmaceutical research and development (R&D), today announced the launch of ... analysis and interpretation for the rapidly evolving field of precision medicine. ...
Breaking Biology Technology: