Navigation Links
'Noise' tunes logic circuit made from virus genes
Date:11/8/2011

In the world of engineering, "noise" random fluctuations from environmental sources such as heat is generally a bad thing. In electronic circuits, it is unavoidable, and as circuits get smaller and smaller, noise has a greater and more detrimental effect on a circuit's performance. Now some scientists are saying: if you can't beat it, use it. Engineers from Arizona State University in Tempe and the Space and Naval Warfare Systems Center (SPAWAR) in San Diego, Calif., are exploiting noise to control the basic element of a computer a logic gate that can be switched back and forth between two different logic functions, such as AND\OR using a genetically engineered system derived from virus DNA. In a paper accepted to the AIP's journal Chaos, the team has demonstrated, theoretically, that by exploiting sources of external noise, they can make the network switch between different logic functions in a stable and reliable way.

The scientists focused on a single-gene network in a bacteriophage λ (lamda). The gene they use regulates the production of a particular protein in the virus. Normally, there are biological reactions that regulate the creation and destruction of this protein; upsetting that balance results in a protein concentration that is either too high or too low. The scientists assigned a "1" to one concentration and a "0" to the other. By manipulating the protein concentration, the team could encode the logic gate input values and obtain the desired output values.

Researchers modeled the system as two potential energy "wells" separated by a hump, corresponding to an energy barrier. In the presence of too much noise, the system never relaxes into one of the two wells, making the output unpredictable. Too little noise, on the other hand, does not provide the boost necessary for the system to reach a high enough protein concentration to overcome the energy barrier; in this case, there is also a high probability that the biological logic gate will fail to achieve its predicted computation. But an optimal amount of noise stabilizes the circuit, causing the system to jump into the "correct well" and stay there. This proof-of-concept work offers the possibility of exploiting noise in biologic circuits instead of regarding it as a laboratory curiosity or a nuisance, the researchers say.


'/>"/>

Contact: Jennifer Lauren Lee
jlee@aip.org
301-209-3099
American Institute of Physics
Source:Eurekalert

Related biology news :

1. Noise pollution negatively affects woodland bird communities, says CU-Boulder study
2. Precise trace gas analysis, without the noise
3. Lone whales shout to overcome noise
4. University of Maryland co-sponsors International Conference on the Effects of Noise on Aquatic Life
5. Noise distracts fish from their dinner
6. Cephalopods experience massive acoustic trauma from noise pollution in the oceans
7. Noise research to combat wind turbine syndrome
8. Unexpected role of noise in spine formation
9. Human genes sing different tunes in different tissues
10. Songbirds tweak their tunes in different ways to cope with clamor
11. NIST tunes metasurface with fluid in new concept for sensing and chemistry
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/21/2016)... Columbia , June 21, 2016 ... to the new role of principal product architect ... named the director of customer development. Both will ... chief technical officer. The moves reflect NuData,s strategic ... in response to high customer demand and customer ...
(Date:6/9/2016)... Paris Police Prefecture and ... ensure the safety of people and operations in several locations ... Teleste, an international technology group specialised in broadband ... its video security solution will be utilised by ... across the country. The system roll-out is scheduled for the ...
(Date:6/2/2016)... , June 2, 2016 Perimeter ... Platforms, Unmanned Systems, Physical Infrastructure, Support & Other Service  ... visiongain offers comprehensive analysis of the global ... market will generate revenues of $17.98 billion in 2016. ... DVTEL Inc, a leader in software and hardware technologies ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... , ... Supplyframe, the Industry Network for electronics hardware design ... Located in Pasadena, Calif., the Design Lab’s mission is to bring together inventors ... and brought to market. , The Design Lab is Supplyframe’s physical representation of ...
(Date:6/23/2016)... Andrew D Zelenetz ... Published recently in Oncology ... touchONCOLOGY, Andrew D Zelenetz , discusses the ... is placing an increasing burden on healthcare systems ... With the patents on many biologics expiring, interest ...
(Date:6/23/2016)... FRANCISCO , June 22, 2016  Amgen (NASDAQ: ... sponsorship of the QB3@953 life sciences incubator ... human health. The shared laboratory space at QB3@953 was ... overcome a key obstacle for many early stage organizations ... part of the sponsorship, Amgen launched two "Amgen Golden ...
(Date:6/22/2016)... June 22, 2016   StockNewsNow.com , The Official ... with Dr. Nader Pourhassan , President & CEO ... on the clinical development and potential commercialization of humanized ... infection, according to the company,s website (see here: ... June 7 th , 2016, at the LD Micro ...
Breaking Biology Technology: