Navigation Links
Noise down, neuron signals up

Biomedical engineer Muhammet Uzuntarla from Bulent Ecevit University, Turkey, and his colleagues present a biologically accurate model of the underlying noise which is present in the nervous system. The article is about to be published in EPJ B. This work has implications for explaining how noise, modulated by unreliable synaptic transmission, induces a delay in the response of neurons to external stimuli as part of the neurons coding mechanism.

Neurons communicate by means of electrical pulses, called spikes, exchanged via synapses. The time it takes for brain cells to first respond to an external stimulus with an electric signal commonly referred to as fist-spike latencyis of particular interest for scientists. It is thought to carry much more neural information than subsequent serial spike signals.

The authors analysed the presence of noise in the nervous system detected through changes in first-spike latency. The noise is due to the synaptic bombardment of each neuron by a large number of incoming excitatory and inhibitory spike inputs. Previous attempts at noise modeling used a generic bell-shaped signal, referred to as a Gaussian approximation. Now, Uzuntarla and his colleagues have devised a noise model that is closer to the biological reality.

They showed there is a relation between the noise and delays in spike signal transmission. The latter is caused by unreliable synapses that do not always transmit the signal, because their chemical-based signalling does not always work. Yet, the authors also demonstrated that synaptic unreliability can be controlled.

To do so, they identified two factors that could be tuned influencing the noise, namely the incoming excitatory and inhibitory input signalling regime and the coupling strength between inhibitory and excitatory synapses. Ultimately, the authors concluded, modulating these factors could help neurons encode information more accurately.


Contact: Janine Haubenreisser

Page: 1

Related biology news :

1. Not just for the birds: Man-made noise has ripple effects on plants, too
2. Unexpected discovery reveals a new mechanism for how the cerebellum extracts signal from noise
3. Human noise has ripple effects on plants
4. ONR taps research teams to help reduce jet noise
5. Researchers have identified a gene with a key role in neuronal survival
6. Glycogen accumulation in neurons causes brain damage and shortens the lives of flies and mice
7. Simple mathematcal pattern describes shape of neuron jungle
8. Ion selectivity in neuronal signaling channels evolved twice in animals
9. Deterring signals: Tobacco plants advertise their defensive readiness to attacking leafhoppers
10. Bacterium signals plant to open up and let friends in
Post Your Comments:
(Date:5/9/2016)... -- Elevay is currently known as the ... high net worth professionals seeking travel for work   ... there is still no substitute for a face-to-face meeting. ... deal with a firm handshake. This is why wealthy ... citizenship via investment programs like those offered by the ...
(Date:4/28/2016)... India , April 28, 2016 ... Infosys (NYSE: INFY ), and Samsung SDS, a ... that will provide end customers with a more secure, ... services.      (Logo: ) , ... services, but it also plays a fundamental part in enabling ...
(Date:4/26/2016)... BANGALORE, India and LONDON ... Infosys Finacle, part of EdgeVerve Systems, a ... ), and Onegini today announced a partnership to ... banking solutions.      (Logo: ... banks to provide their customers enhanced security to ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... June 27, 2016 , ... Cancer ... what they believe could be a new and helpful biomarker for malignant pleural ... Click here to read it now. , Biomarkers are components in the ...
(Date:6/27/2016)... (PRWEB) , ... June 27, 2016 , ... ... operations for Amgen, will join the faculty of the University of North ... adjunct professor of strategy and entrepreneurship at UNC Kenan-Flagler, with a focus on ...
(Date:6/24/2016)...  Regular discussions on a range of subjects including policies, ... entities said Poloz. Speaking at a lecture to ... he pointed to the country,s inflation target, which is set ... "In certain areas there needs ... economic goals, why not sit down and address strategy together?" ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Researchers at the ... commonly-identified miRNAs in people with peritoneal or pleural mesothelioma. Their findings are the subject ... it now. , Diagnostic biomarkers are signposts in the blood, lung fluid or ...
Breaking Biology Technology: