Navigation Links
Nobel Laureate Jules Hoffmann kicks off Annual Drosophila Research Conference
Date:4/4/2013

mmunity is front-line and immediate; adaptive immunity has memory and specificity.

Dr. Hoffmann and his colleagues' expected the innate immune system in the fly to be completely different from that in a mammal, but they were in for a surprise. Within a few years, thanks to Dr. Hoffmann's lab and the work of several other labs in mammals, including those of Charles A. Janeway, MD, and Bruce A. Beutler, MD, they showed that flies and mammals share many of the mechanisms of innate immunity. "These range from receptors for microbial aggressors, to intracellular signaling cascades, which control the expression of immune response genes, and the genes encoding potent antimicrobial peptides," Dr. Hoffmann explained.

Genomic analysis enabled the Hoffmann group to set the date for the emergence of innate immunity. "Innate immunity appeared with multicellularity, possibly one billion years ago. The various zoological phyla have played with a toolbox of genes encoding receptors, adaptors, kinases, transactivators, and antimicrobial peptides according to their own agendas, essentially their own environments and pathogens," he said.

At the crux of the Hoffmann lab body of work is the Toll receptor, a protein that straddles the cell membranes of immune system "sentinel" cells, detecting molecular nametags of pathogens from the outside and transducing messages to the inside, activating and orchestrating defense against infection.

The Toll receptor had been discovered in 1985 as a regulator of embryo polarity, but Dr. Hoffmann's group linked it to fungal infection in flies in 1996 and then to Gram-positive bacterial infections. During this time Dr. Hoffmann became director of the CNRS Institute of Cellular and Molecular Biology. A year later, Dr. Janeway and his lab at Yale discovered Toll-like receptors that activate and amplify the specific, adaptive immune response in humans.

Dr. Hoffmann acknowledged many scientists and labs wh
'/>"/>

Contact: Phyllis Edelman
pedelman@genetics-gsa.org
301-351-0896
Genetics Society of America
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Crowdsourcing to kickstart comeback from ash dieback
2. Annual Drug Discovery Conferences Being Held in Boston MA, Spring 2012
3. Registration open for the Ecological Society of Americas 2012 Annual Meeting in Portland, Ore.
4. 5th Annual Advances in Biomolecular Engineering Symposium
5. 2012 ARVO Award recipients honored at annual meeting
6. Cracking the Neural Code: Third Annual Aspen Brain Forum
7. DOE Plasma Science Center Annual Meeting at Princeton Plasma Lab
8. 6th Annual Canadian Neuroscience Meeting, Vancouver, May 20-23, 2012
9. European Society of Human Reproduction and Embryology 28th Annual Meeting -- Istanbul
10. BioMed Central announces winners of 6th Annual Research Awards
11. John Theurer Cancer Center presents significant blood cancer research at 2012 ASCO Annual Meeting
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/24/2015)... 24, 2015 This report analyzes the worldwide markets for ... Face Biometrics, and Voice Biometrics. The report provides separate comprehensive analytics ... , Europe , Asia-Pacific ... , and Latin America . Annual estimates ... a seven-year historic analysis is provided for these markets. Market data ...
(Date:2/13/2015)... , Feb. 13, 2015 ACT Genomics ... that aims to transform cancer genomic information into ... the company has raised US$ 8 million in the ... in Taipei, Taiwan , ACT ... ACTOnco™. With the aim to implement next generation ...
(Date:2/9/2015)... 9, 2015  Lintec of America recently announced an ... nanotube (CNT) macrostructures, including sheets, yarns and ribbons, developed ... Leveraging the vast industrial resources of the global ... , Lintec of America is forming the Nano-Science and ... , focusing on scaling up the manufacturing and commercialization ...
Breaking Biology News(10 mins):World Face and Voice Biometrics Industry 2World Face and Voice Biometrics Industry 3World Face and Voice Biometrics Industry 4World Face and Voice Biometrics Industry 5World Face and Voice Biometrics Industry 6World Face and Voice Biometrics Industry 7World Face and Voice Biometrics Industry 8World Face and Voice Biometrics Industry 9World Face and Voice Biometrics Industry 10World Face and Voice Biometrics Industry 11World Face and Voice Biometrics Industry 12World Face and Voice Biometrics Industry 13World Face and Voice Biometrics Industry 14World Face and Voice Biometrics Industry 15World Face and Voice Biometrics Industry 16ACT Genomics Raises $8 Million in its First Private Funding Round 2Lintec announces exclusive license to commercialize innovative carbon nanotube technology from the University of Texas at Dallas 2Lintec announces exclusive license to commercialize innovative carbon nanotube technology from the University of Texas at Dallas 3Lintec announces exclusive license to commercialize innovative carbon nanotube technology from the University of Texas at Dallas 4
... in Genome Research on Nov. 4, scientists at ... previously believed to be "junk" DNA is one of the ... 50 percent of human DNA has been referred to as ... A major source of these repeats is internal viruses that ...
... hormone produced by fat and other tissues into mice, researchers ... significantly lowered blood sugar levels in normal and obese mice. ... be a promising target for managing insulin resistance and type ... insulin are insufficient to lower blood sugar (glucose) levels, is ...
... the near future it will be possible to customise ... the genetic profile of the individual. Dutch researcher Amber ... ready for this so-called nutrigenomics. Ronteltap concludes that many ... become a reality. Nutrigenomics is a discipline ...
Cached Biology News:'Junk' DNA proves functional 2'Junk' DNA proves functional 3Apelin hormone injections powerfully lower blood sugar 2Consumer not ready for tailor-made nutrition 2
(Date:2/27/2015)... , Feb. 27, 2015 A ... the NCATS rare-diseases portfolio " in Science ... new financing technique to reduce the risk associated ... and potentially unlock new levels of funding for ... product of a unique collaboration between scientists at ...
(Date:2/27/2015)... The fully automated supercritical fluidic chromatography-based ... analyze up to 48 samples utilizing automatic extraction ... targets by mass spectrometry. , The Nexera ... requirements of a wide range of applications, including ... search for disease biomarkers, additives in forming polymers, ...
(Date:2/27/2015)... (PRWEB) February 27, 2015 FamilyFarms Group ... General Manager of State Line Farms, received the 2015 ... a producer, under the age of 35, who has ... is an honor to win the Tomorrow's Top Producer ... who won the Top Producer Award and learning from ...
(Date:2/27/2015)... BOSTON , Feb. 27, 2015   PureTech ... identifying, inventing and commercializing disruptive products and technologies in ... Christopher Viehbacher , former CEO and Member of the ... Directors.  "It,s has been a pleasure ... very excited that we will be working together more ...
Breaking Biology Technology:New Financing Technique May Hold Key to Unlocking Funding for Rare Diseases 2New Financing Technique May Hold Key to Unlocking Funding for Rare Diseases 3New Financing Technique May Hold Key to Unlocking Funding for Rare Diseases 4Shimadzu Corporation Launches Nexera UC - The World’s Foremost Unified Chromatography System 2Shimadzu Corporation Launches Nexera UC - The World’s Foremost Unified Chromatography System 3Matt Sims Receives the 2015 Tomorrow’s Top Producer Horizon Award 2Christopher Viehbacher, former CEO of Sanofi, Joins PureTech's Board of Directors 2Christopher Viehbacher, former CEO of Sanofi, Joins PureTech's Board of Directors 3Christopher Viehbacher, former CEO of Sanofi, Joins PureTech's Board of Directors 4
... Safe Plastics Technology Behind Best Inventor Pitch for,U-Md. Bioscience ... University of,Maryland professor who invented a new technology enabling ... won the attention of a group of,venture capitalists and ... held Nov. 13., Sponsored by the university,s Office ...
... Exchange Symbol: MS, EDMONTON, Nov. 14 /PRNewswire-FirstCall/ ... in the treatment of multiple sclerosis (MS), today,announced ... ended,September 30, 2007. "During the quarter, we ... lead drug, MBP8298, for the treatment of multiple,sclerosis," ...
... BEIJING, Nov. 14 /Xinhua-PRNewswire/ -- The directors of Sunrise Biotech,Holding Limited ("Sunrise" or the "Company"), ... for the admission of its entire ordinary share capital for trading on,the PLUS Market., ... Biology Technology, PRINCIPLE ACTIVITIES ... ...
Cached Biology Technology:Pure Plastics Pitch Proves Perfect 2Pure Plastics Pitch Proves Perfect 3BioMS Medical announces third quarter 2007 results 2BioMS Medical announces third quarter 2007 results 3BioMS Medical announces third quarter 2007 results 4Sunrise Biotech Holding Limited Application For Admission to PLUS 2
... Lone Wolf valve has the highest performance ... available on the market. This VSO valve ... and ensures maximum accuracy., Achieves rapid, ... and patient comfort. , Maintains ideal flow ...
Normal Hamster Serum...
...
Hamster Serum; U.S. sourced, ideal for those who seek an uncompromising quality. Low Hemoglobin levels; U.S. sourced, ideal for those who seek an uncompromising quality. Low Hemoglobin levels....
Biology Products: