Navigation Links
Nobel Laureate Jules Hoffmann kicks off Annual Drosophila Research Conference
Date:4/4/2013

mmunity is front-line and immediate; adaptive immunity has memory and specificity.

Dr. Hoffmann and his colleagues' expected the innate immune system in the fly to be completely different from that in a mammal, but they were in for a surprise. Within a few years, thanks to Dr. Hoffmann's lab and the work of several other labs in mammals, including those of Charles A. Janeway, MD, and Bruce A. Beutler, MD, they showed that flies and mammals share many of the mechanisms of innate immunity. "These range from receptors for microbial aggressors, to intracellular signaling cascades, which control the expression of immune response genes, and the genes encoding potent antimicrobial peptides," Dr. Hoffmann explained.

Genomic analysis enabled the Hoffmann group to set the date for the emergence of innate immunity. "Innate immunity appeared with multicellularity, possibly one billion years ago. The various zoological phyla have played with a toolbox of genes encoding receptors, adaptors, kinases, transactivators, and antimicrobial peptides according to their own agendas, essentially their own environments and pathogens," he said.

At the crux of the Hoffmann lab body of work is the Toll receptor, a protein that straddles the cell membranes of immune system "sentinel" cells, detecting molecular nametags of pathogens from the outside and transducing messages to the inside, activating and orchestrating defense against infection.

The Toll receptor had been discovered in 1985 as a regulator of embryo polarity, but Dr. Hoffmann's group linked it to fungal infection in flies in 1996 and then to Gram-positive bacterial infections. During this time Dr. Hoffmann became director of the CNRS Institute of Cellular and Molecular Biology. A year later, Dr. Janeway and his lab at Yale discovered Toll-like receptors that activate and amplify the specific, adaptive immune response in humans.

Dr. Hoffmann acknowledged many scientists and labs wh
'/>"/>

Contact: Phyllis Edelman
pedelman@genetics-gsa.org
301-351-0896
Genetics Society of America
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Crowdsourcing to kickstart comeback from ash dieback
2. Annual Drug Discovery Conferences Being Held in Boston MA, Spring 2012
3. Registration open for the Ecological Society of Americas 2012 Annual Meeting in Portland, Ore.
4. 5th Annual Advances in Biomolecular Engineering Symposium
5. 2012 ARVO Award recipients honored at annual meeting
6. Cracking the Neural Code: Third Annual Aspen Brain Forum
7. DOE Plasma Science Center Annual Meeting at Princeton Plasma Lab
8. 6th Annual Canadian Neuroscience Meeting, Vancouver, May 20-23, 2012
9. European Society of Human Reproduction and Embryology 28th Annual Meeting -- Istanbul
10. BioMed Central announces winners of 6th Annual Research Awards
11. John Theurer Cancer Center presents significant blood cancer research at 2012 ASCO Annual Meeting
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... ALBUQUERQUE, N.M. A credit-card-sized anthrax detection cartridge developed ... small business makes testing safer, easier, faster and cheaper. ... causes anthrax, is commonly found in soils all over ... illness in both humans and animals. The bacteria can ... to B. anthracis may occur through skin ...
(Date:4/17/2014)... Kansas State University engineer has developed a patented ... improvised explosive devices. The same technique could help ... Steven M. and Kay L. Theede chair in ... engineering, and his research team have created a ... in car trunks. The distance detection method ...
(Date:4/17/2014)... professor Rajendra Singh Thursday as a "Champion of ... solar deployment in the residential, commercial and industrial ... of Electrical and Computer Engineering and director of ... local hero leading the charge across the country ... power and driving policy changes at the local ...
Breaking Biology News(10 mins):Pocket-sized anthrax detector aids global agriculture 2Pocket-sized anthrax detector aids global agriculture 3Patented research remotely detects nitrogen-rich explosives 2White House honors Clemson professor as 'Champion of Change' for solar deployment 2
... working with Professor Dr. Dr. Perikles Simon, head of the ... Germany, suggest in the light of recent analyses that German ... up to the age of five years, today,s children,s weight ... Then as now there are about 10 percent of the ...
... sitting on a goal post could attract a male moth on ... switched her scent over time, the male could still find her ... A team of researchers led by Montana State University entomologist ... even the slightest change in the chemicals female moths emit to ...
... of chemical attacks and help save lives, it,s vital ... deadly chemicalssuch as the nerve gas sarin and other ... a new chemical sensor that can simultaneously identify a ... paper describing the system has been published today in ...
Cached Biology News:When do German children gain weight? 2When do German children gain weight? 3Team discovers reason that male moths can keep finding females 2Team discovers reason that male moths can keep finding females 3Hearing the telltale sounds of dangerous chemicals 2Hearing the telltale sounds of dangerous chemicals 3
(Date:1/15/2014)... 15, 2014  Bill Jacobs Automotive, a group of car dealerships ... with the Heartland Blood Center and offering free oil change ... takes place Saturday, Jan. 18 at the Bill Jacobs Cadillac ... (Photo: http://photos.prnewswire.com/prnh/20140115/MN46637 )  The Bill ...
(Date:1/15/2014)... England and SAN JOSE, California ... international biotechnology company developing antibody-drug conjugates for cancer, today announced ... Board of Directors. Dr Reynolds has over 20 years, development ... Medical Officer at Seattle Genetics. "I am delighted ...
(Date:1/15/2014)... January 15, 2014 Two champions of ... their sponsorship of an annual competition for middle and ... access to, innovative STEM study. The competition presents students ... Tests of Engineering Aptitude, Mathematics, and Sciences is ...
(Date:1/15/2014)... 15, 2014 AudioNotch is the internet's ... for the treatment of tinnitus. Patients listen to sound ... over a period of weeks to months, their tinnitus volume ... two forms: Notched Music and Notched White Noise. Now, AudioNotch ...
Breaking Biology Technology:Join the Bill Jacobs Auto blood drive and receive a free oil change 2Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 2Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 2Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 4Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 5
... MCLEAN, Va., Aug. 3, 2011 HumanTouch, LLC today ... 2011 Fast 50 Government Contractors list.   ... to adapt to ever-changing market conditions and build a ... companies that populate the Fast 50 range from resellers ...
... Omeros Corporation (NASDAQ: OMER ), a biopharmaceutical ... on inflammation, bleeding and disorders of the central nervous ... and chief executive officer, is scheduled to present at ... Genuity Growth Conference August 10, 2011 9:00 a.m. ...
... 2011 Cambrex Corporation (NYSE: CBM ) reports second ... Highlights Reported sales increased by ... compared to the second quarter of 2010. EBITDA was $13.2 ... compared to $12.1 million in the second quarter of 2010. ...
Cached Biology Technology:Cambrex Reports Second Quarter of 2011 Results 2Cambrex Reports Second Quarter of 2011 Results 3Cambrex Reports Second Quarter of 2011 Results 4Cambrex Reports Second Quarter of 2011 Results 5Cambrex Reports Second Quarter of 2011 Results 6Cambrex Reports Second Quarter of 2011 Results 7Cambrex Reports Second Quarter of 2011 Results 8