Navigation Links
No more free rides for 'piggy-backing' viruses
Date:1/4/2012

Scientists have determined the structure of the enzyme endomannosidase, significantly advancing our understanding of how a group of devastating human viruses including HIV and Hepatitis C hijack human enzymes to reproduce and cause disease.

The findings open the door to the development of new drugs to combat these deadly viruses that infect more than 180 million people worldwide.

The team of international scientists led by and Professor Gideon Davies from the University of York and Associate Professor Spencer Williams from the University of Melbourne, studied bacterial endomannosidase as a model for the same human enzyme and successfully determined the three dimensional structure of the enzyme using state of the art synchrotron technology.

Professor Davies, of the Department of Chemistry at York, said that knowing the structure of the enzyme revealed details on how viruses play biological "piggy-back", borrowing our cellular machinery to replicate and cause disease

"If we understand how the viruses use our enzymes, we can develop inhibitors that block the pathway they require, opening the door to drug developments," he said.

In the past the problem has been that this group of viruses including HIV, Hepatitis C, Dengue Fever and West Nile virus, are able to bypass the main pathway if inhibited and replicate via a second pathway using this enzyme. Thus for a treatment to be effective, both pathways need to be blocked.

"It was already known how to block the main pathway for these viruses but until now, this endomannosidase bypass pathway has proved a considerable challenge to study," Professor Davies said.

Dr Williams said: "Combining international resources and expertise, we were able to determine the endomannosidase structure and this has revealed how we can block the bypass route, stopping the viruses from hijacking human enzymes."

Professor Davies added: "We hope that the work will lead beyond viruses and will point the way towards similar treatments for other diseases including cancer."


'/>"/>
Contact: David Garner
david.garner@york.ac.uk
44-019-043-22153
University of York
Source:Eurekalert

Related biology news :

1. Migratory moths may hitch their rides, but theyre anything but drifters
2. Scientists make strides toward defining genetic signature of Alzheimers disease
3. New approach discovered to lowering triglycerides
4. First Arizona Strides for Life event nets $25,000 for TGen research
5. Strides in identifying and improving screening practices and treatment for liver diseases
6. UCSB scientists make strides in vision research
7. Mannan oligosaccharides offer health benefits to pigs
8. Structures of important plant viruses determined
9. Research about plant viruses could lead to new ways to improve crop yields
10. World leaders in infectious diseases convene to discuss emerging global viruses
11. Forced evolution: Can we mutate viruses to death?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/19/2017)... 19, 2017 The global military ... is marked by the presence of several large global ... by five major players - 3M Cogent, NEC Corporation, ... for nearly 61% of the global military biometric market ... the global military biometrics market boast global presence, which ...
(Date:4/17/2017)... 2017 NXT-ID, Inc. (NASDAQ: NXTD ) ... of its 2016 Annual Report on Form 10-K on Thursday April ... ... in the Investor Relations section of the Company,s website at ... at http://www.sec.gov . 2016 Year Highlights: ...
(Date:4/13/2017)... 13, 2017 According to a new market research ... Analytics, Identity Administration, and Authorization), Service, Authentication Type, Deployment Mode, Vertical, and ... is expected to grow from USD 14.30 Billion in 2017 to USD ... 17.3%. ... MarketsandMarkets Logo ...
Breaking Biology News(10 mins):
(Date:5/24/2017)... 2017 As Ebola resurfaces in the ... 20 suspected cases now reported, a new analysis of the ... a correlation between the 2014 and 2017 outbreaks of the ... in 2012-13, which preceded the 2014 outbreak. An analysis of ... Replikin counts in 2014-15, which again precedes the current outbreak ...
(Date:5/23/2017)... ... May 23, 2017 , ... A recent survey conducted by the Weed Science ... control weed in 12 categories of broadleaf crops, fruits and vegetables, while common lambsquarters ... U.S. and Canada participated in the 2016 survey, the second conducted by WSSA. ...
(Date:5/23/2017)... , ... May 23, 2017 , ... ... this month its 20th anniversary, marking the occasion with a strong presence at ... meeting’s Welcome Reception and further extends an invitation to all attendees to view ...
(Date:5/23/2017)... ... May 22, 2017 , ... A new Technology Hot Topics ... this August will feature high-level speakers on quantum devices, graphene electronic tattoo sensors, ... Photonics, the largest multidisciplinary optical sciences meeting in North America, will run 6-10 ...
Breaking Biology Technology: