Navigation Links
No hiding place for infecting bacteria

Scientists in Colorado have discovered a new approach to prevent bacterial infections from taking hold. Writing in the Journal of Medical Microbiology, Dr Quinn Parks and colleagues describe how they used enzymes against products of the body's own defence cells to prevent Pseudomonas aeruginosa bacteria from building a protective biofilm which enables them to avoid both the body's immune mechanisms and antibiotics.

When the body's defence cells, called neutrophils, attack P. aeruginosa, the cell contents - including a protein called F-actin and the cell's DNA are released. P. aeruginosa uses these cell proteins as a scaffold to build a protective biofilm making these infections very difficult to treat. P. aeruginosa biofilms cause disease in burns, wounds, contact lens infections and are particularly prevalent in the lungs of cystic fibrosis patients.

"We specifically targeted the F-actin protein with a negatively charged peptide, and the DNA with the enzyme DNase, which both prevented and disrupted the formation of P. aeruginosa biofilms in the presence of human neutrophils." said Dr Parks. "These results suggest a new combined therapeutic strategy for the treatment of P. aeruginosa infections.


Contact: Dianne Stilwell
Society for General Microbiology

Page: 1

Related biology news :

1. Emphasis on conifer forests places multiple species at risk
2. Opportunity for students displaced by Katrina to assess climate vulnerability of Southeast US
3. IEEE-USA innovation forum will help prepare US tech leaders to prosper in a global marketplace
4. In-vitro fertilization improved with 3-D/4-D-guided embryo transfer and new placement target
5. Single-largest biodiversity survey says primary rainforest is irreplaceable
6. Katherine Freed wins first place at the International ISPE Undergraduate Poster Contest
7. Listen-up ladies: Dont postpone knee-replacement surgery
8. MU researcher links hormone replacement therapy to breast cancer
9. A place in the sun
10. Testosterone replacement theraphy beneficial in men 60 and older
11. Clues to ancestral origin of placenta emerge in Stanford study
Post Your Comments:
(Date:11/9/2015)... , Nov. 9, 2015  Synaptics Inc. (NASDAQ: ... today announced broader entry into the automotive market with ... match the pace of consumer electronics human interface innovation. ... are ideal for the automotive industry and will be ... Europe , Japan ...
(Date:10/29/2015)... , Oct. 29, 2015  The J. Craig Venter ... titled, "DNA Synthesis and Biosecurity: Lessons Learned and Options ... of Health and Human Services guidance for synthetic biology ... --> --> ... has the potential to pose unique biosecurity threats. It ...
(Date:10/29/2015)... , October 29, 2015 ... authentication company focused on the growing mobile commerce ... announces that StackCommerce, a leading marketplace to discover ... the Wocket® smart wallet on StackSocial for this ... ("NXT-ID" or the "Company"), a biometric authentication company ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... - ProMetic Life Sciences Inc. (TSX: PLI) (OTCQX: PFSCF) ("ProMetic" ... , President and Chief Executive Officer of ProMetic, will be ... th Annual Healthcare Conference to be held at the ... st , at 8.50am (ET) and ProMetic,s management team ... presentation will be available live via a webcast accessible at ...
(Date:11/24/2015)... Nev. , Nov. 24, 2015  PDL BioPharma, Inc. ... P. McLaughlin , the company,s president and chief executive officer, ... Healthcare Conference next week in New York City ... occur on Tuesday, December 1, 2015 at 9:30 a.m. EST. ... Please connect to the website at least 15 minutes prior ...
(Date:11/24/2015)... Nov. 24, 2015 According to two new studies, ... This is something that many doctors, scientists, and public health ... remains: with fewer PSA tests being done, will there be ... Dr. David Samadi, "Despite the efforts made in ... the second leading cancer cause of death in men, killing ...
(Date:11/23/2015)... 2015 China Cord Blood Corporation (NYSE: ... of cord blood collection, laboratory testing, hematopoietic stem cell ... preliminary unaudited financial results for the second quarter and ... 2015. --> --> ... for the second quarter of fiscal 2016 increased by ...
Breaking Biology Technology: