Navigation Links
No harm to mice testes from BPA in utero
Date:9/22/2011

counts, and testosterone levels of BPA-exposed mice were also not significantly different. The mice exposed to the chemical also did not show any abnormal amount of cell death among cells that make sperm or in the levels of mRNA associated with testis maturation.

LaRocca and Hixon hypothesize that the mothers and their growing sons are able to detoxify much of the BPA via their metabolism, an important reason to test BPA exposure via the digestive system, the most common route of exposure to humans. BPA, which has been used in baby bottles and to line soda cans, leaches into the liquids people drink.

"So while the [mother] has the dose of 50 micrograms per kilogram, by the time it reaches the fetus that dose is much, much lower than if you were to inject the animal," LaRocca said.

"Humans are not going to get the exposure the animals were exposed to," Hixon added.

But by this ingestion method the researchers did find several negative effects of exposure to DES, a synthetic estrogen prescribed from the late 1930s to the early 1970s in hopes of preventing pregnancy complications. In the mice, DES significantly reduced litter size and steroidogenesis mRNA expression.

And the females?

Hixon and LaRocca cautioned that while their study may offer some encouragement for male reproductive health to the extent it can be extrapolated from mice to men, it does not mean that BPA is harmless.

Hixon noted that the research team did not test whether the sperm of BPA-exposed mice were actually fertile.

More concerning is their data on the reproductive development of the female mouse pups born in the study. Although that analysis is more preliminary and still unpublished, it shows signs of lasting negative effects of BPA exposure in their mammary glands and ovaries.

In addition to Hixon and LaRocca, other authors on the paper include Alanna Boyajian, Caitlin Brown, and Stuart Duncan Smith.


'/>"/>

Contact: David Orenstein
david_orenstein@brown.edu
401-863-1862
Brown University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Human adult testes cells can become embryonic-like
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/14/2015)... , April 14, 2015  HYPR Corp. ... Online (FIDO ® ) Alliance tm , an ... FIDO members commit to share technology and collaborate ... that are interoperable, more secure and private, and ... biometric identity verification that protects sensitive user information ...
(Date:4/13/2015)... , April 13, 2015  higi, a leading cloud-based ... to more fully engage with their communities around health ... privacy protected and secure API.  ... the most accessible, affordable, and convenient vehicle to receive ... The API will allow higi,s ...
(Date:4/8/2015)... , April 8, 2015  Infinisource, a leading ... services, and Morpho, a leading supplier of biometric ... produce the market,s most advanced biometrically-enabled time clock, ... NXG time clock is setting a bold, new ... data for the small and mid-size employer. When ...
Breaking Biology News(10 mins):HYPR Corp. Joins the FIDO Alliance 2HYPR Corp. Joins the FIDO Alliance 3higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 2higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 3iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 3
... , COLUMBIA, Mo. A primary characteristic of ... skills. Children and adolescents with social-communication problems face ... of Missouri researchers found that children who receive ... at early ages, achieve the best outcomes. ...
... Following a week of tumultuous sleepless nights and ... bi-annual U.S. Department of Energy (DOE) Solar Decathlon ... Potomac Park in Washington, DC. (To view ... .) ENJoy: A Generation House, has ...
... University,s Precourt Institute for Energy (PIE) and TomKat Center ... totaling more than $2.2 million for promising new research ... grants is to help jumpstart new projects with the ... Director Lynn Orr, professor of energy resources engineering. ...
Cached Biology News:Children with autism benefit from early, intensive therapy 2Team NJ house opens on DC Mall following week of round-the-clock work 2Team NJ house opens on DC Mall following week of round-the-clock work 3Stanford Precourt Institute and TomKat Center award energy research grants 2Stanford Precourt Institute and TomKat Center award energy research grants 3Stanford Precourt Institute and TomKat Center award energy research grants 4Stanford Precourt Institute and TomKat Center award energy research grants 5
(Date:4/24/2015)... April 24, 2015 The South Dakota ... (ASU) have entered into an agreement to promote cooperation ... of agreement signed by the universities will encourage and ... and other services particularly, though not exclusively, relating to ... complementary strengths and a similar set of values,” said ...
(Date:4/24/2015)... April 24, 2015 /PRNewswire/ - BioAmber Inc. (NYSE: ... as the supplier of bio-succinic acid used to ... for textile applications that Bayer MaterialScience has begun ... IMPRANIL ® eco, a series of bio-based ... as high as 65%.  IMPRANIL ® eco ...
(Date:4/24/2015)...  Navitas Life Sciences is delighted to announce the appointment ... Regulatory Services. Shalabh is a proven leader in Life Science ... Kinapse, as well as a Strategy consultant at Accenture. ... http://photos.prnewswire.com/prnh/20150423/201261LOGO ... delighted to welcome Shalabh into this critical role and also ...
(Date:4/23/2015)... Marshall, MN (PRWEB) April 24, 2015 ... agreement with Advanced Birthright Nutrition® (ABN) for the exclusive ... Milk Cup. The new technology is a new in-line ... swine producers by allowing them to move supplementation milk ... running. , “This technology lets producers get ...
Breaking Biology Technology:South Dakota Mines, Arizona State University Pave Way for Cooperative Research 2Bayer MaterialScience Names BioAmber As Its Supplier For New Product Line - Bio-succinic acid forms backbone of innovative new bio-based polyurethanes for textiles 2Bayer MaterialScience Names BioAmber As Its Supplier For New Product Line - Bio-succinic acid forms backbone of innovative new bio-based polyurethanes for textiles 3Bayer MaterialScience Names BioAmber As Its Supplier For New Product Line - Bio-succinic acid forms backbone of innovative new bio-based polyurethanes for textiles 4Shalabh Kumar Joins Navitas Life Sciences to Lead their Clinical and Regulatory Services Teams 2Ralco Acquires License to Birthright™ Moveable Milk Cup 2
... CORGENIX EXCLUSIVE WORLDWIDE RIGHTS TO DIAGNOSTIC, ... INFLAMMATION, DENVER, March 18 Corgenix ... developer and marketer of,diagnostic test kits, has ... Industrial Promotion Foundation covering new diagnostic,technology for ...
... Corp. announces,FDA 510(k) Clearance of the new ... is based on a miniature 3.4 mm ... and endoscopic Surgery (MIS)., Visionsense,s stereoscopic ... that are under served by traditional 2D ...
... - Aegera Therapeutics announced today,the initiation of ... AEG33773, a,novel, orally bioavailable small molecule in ... The Phase I study will evaluate the ... a randomized,double blind, placebo controlled, single ascending ...
Cached Biology Technology:Corgenix Signs Technology Licensing Agreement With Japanese Government 2Aegera initiates Phase 1 clinical trial of AEG33773 - A small molecule in development for diabetic neuropathic pain 2
Applications: ISH...
... Immunogen: Recombinant human IDO ... for the ~44 kDa human ... (positive control: IFN-Gamma-stimmulated Human peripheral ... homology reactivity with mouse and ...
...
TRIzol Reagents are ready-to-use monophasic solutions of phenol and guanidine isothiocyanate suitable for isolating total RNA DNA and proteins (16)....
Biology Products: