Navigation Links
No harm to mice testes from BPA in utero
Date:9/22/2011

PROVIDENCE, R.I. [Brown University] -- Bisphenol A (BPA), a common component of plastic used in many consumer products, has recently become infamous -- and banned in some places -- because it can mimic natural estrogen in the body. A new study by Brown University toxicologists, however, finds that male mice whose mothers were exposed even to high doses of BPA while pregnant developed no signs of harm to their testes as adults.

"This might alleviate some worries for the general public," said Mary Hixon, assistant professor (research) of pathology and laboratory medicine in the Warren Alpert Medical School of Brown University and the paper's senior author. "It comes down to the biology."

The research, funded by a grant from the National Institutes of Health, appears in advance online in the journal Birth Defects Research (Part B).

In the study, a team led by Hixon and lead author Jessica LaRocca, a graduate student, exposed mice to BPA during days 10 through 16 of their pregnancy, the period of time when the sexual organs of their fetuses were developing.

Some pregnant mice consumed a solution with a concentration of BPA at the EPA-acceptable level, and other pregnant mice were given a solution at a concentration 20 times higher. The experimenters' negative controls were given sesame oil, and the positive controls were given diethylstilbestrol (DES), a much more potent estrogen mimicking chemical.

The researchers then studied the litter size and viability of each mother's pups and later studied several characteristics of the reproductive organs of their adult sons.

What they found is that by every measure at either dose level, the BPA did no apparent harm. The litter sizes of BPA-exposed mothers were not affected compared to the negative control, both at birth and at weaning. In the adult male mice, testis weight, body weight, and seminal vesicle weight were no different. The seminiferous tubules, sperm
'/>"/>

Contact: David Orenstein
david_orenstein@brown.edu
401-863-1862
Brown University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Human adult testes cells can become embryonic-like
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2014)... considered the most ideal source of nutrition for ... role in the evolution and civilizations of human ... a large number of bacterial species, including some ... no surprise to scientists and physicians. , Indeed, ... be the result of co-evolutionary and co-adaptive interactions ...
(Date:9/2/2014)... 2014 A study published in the September ... American Academy of Child and Adolescent Psychiatry ... psychiatric diagnosis had an increased risk of developing ... Using data from the nationwide Danish registers, a ... Nielsen, Psychiatry, Aalborg University Hospital, Denmark, studied 48,299children ...
(Date:9/2/2014)... N.C. -- When you accidentally touch a hot oven, ... the basic neural circuits involved in sensing and responding ... the molecular players. , Duke researchers have made a ... involved in pain in worms, and have built a ... 2 in Nature Communications , may help direct ...
Breaking Biology News(10 mins):Are human breast milk microbiome 'neutral'? 2Are human breast milk microbiome 'neutral'? 3Risk of diabetes in children and adolescents exposed to antipsychotics 2Surprising new role for calcium in sensing pain 2Surprising new role for calcium in sensing pain 3
... Department of Community Health (MDCH) has unveiled the ... includes significant recommendations developed from medical research conducted ... Eunice Kennedy Shriver National Institute for Child Health ... at the Wayne State University School of Medicine. ...
... press release is available in German . ... great happiness among inhabitants. On those days the air is ... difficult and unhealthy. According to the latest calculations of Max ... most of world population in 2050 if no counteractive measures ...
... Butterflies learn faster when a flower is rewarding than when ... when it comes to speed of learning with rewards. These ... Kandori and Takafumi Yamaki from Kinki University in Japan. Their ... Science of Nature , is the first to investigate and ...
Cached Biology News:State of Michigan adopts NIH's PRB progesterone therapy to combat infant mortality 2State of Michigan adopts NIH's PRB progesterone therapy to combat infant mortality 3Worldwide increase of air pollution 2Rewarding work for butterflies 2
(Date:9/2/2014)... 2014 Reportbuyer.com has added a new ... Products and Global Markets https://www.reportbuyer.com/product/1923022/Human-Reproductive-Technologies-Products-and-Global-Markets.html ... The objective of the study is to present ... reproductive technologies and products. Markets are divided according ... some markets are mature, while products in other ...
(Date:9/2/2014)... NEW PROVIDENCE, N.J. , Sept. 2, ... a corporate sponsor for MassBio,s 20th Annual Golf Classic, ... MassBioEd Foundation. The event will be held on September ... Plymouth, Massachusetts . The ... Massachusetts through educational programs, workforce development, ...
(Date:9/2/2014)... Ore. -- Scientists, including University of Oregon chemist ... create scaffolds of self-assembling, synthetic proteins called peptoid ... , The accomplishment -- detailed this week in ... the Proceedings of the National Academy of ... alternative design of the two-dimensional peptoid nanosheets that ...
(Date:9/2/2014)... , Sept. 2, 2014  Technology Applications International Corporation ... its wholly-owned subsidiary Renuell Int,l, Inc. has signed an ... Space Administration ("NASA") at the Johnson Space Center in ... See photos: tapplic.com/houstonphotos/ ... very pleased to announce our latest, exclusive agreement with ...
Breaking Biology Technology:Human Reproductive Technologies: Products and Global Markets 2Human Reproductive Technologies: Products and Global Markets 3Human Reproductive Technologies: Products and Global Markets 4Human Reproductive Technologies: Products and Global Markets 5Human Reproductive Technologies: Products and Global Markets 6Human Reproductive Technologies: Products and Global Markets 7Human Reproductive Technologies: Products and Global Markets 8Human Reproductive Technologies: Products and Global Markets 9Human Reproductive Technologies: Products and Global Markets 10Human Reproductive Technologies: Products and Global Markets 11Human Reproductive Technologies: Products and Global Markets 12Human Reproductive Technologies: Products and Global Markets 13Human Reproductive Technologies: Products and Global Markets 14Human Reproductive Technologies: Products and Global Markets 15Human Reproductive Technologies: Products and Global Markets 16Human Reproductive Technologies: Products and Global Markets 17Linde helps fund STEM education in Massachusetts 2Linde helps fund STEM education in Massachusetts 3UO-Berkeley Lab unveil new nano-sized synthetic scaffolding technique 2Technology Applications International Corporation Subsidiary Enters Into Additional Exclusive Agreement with NASA at a Signing Ceremony at the Johnson Space Center In Houston, Texas 2Technology Applications International Corporation Subsidiary Enters Into Additional Exclusive Agreement with NASA at a Signing Ceremony at the Johnson Space Center In Houston, Texas 3
... dispute NimbleGen releases microarrays for DNA encyclopedia ... percent Icon Interactive lands animator as client ... managemenet Teklynx releases design software for UCC-compliant ... Benitec in contract dispute , Promega , an international ...
... In his new book The Art of the ... , Guy Kawasaki, a managing director of Garage Technology ... venture capital, most entrepreneurs would be better off spending ... relationships. , ,This is a good message, but ...
... will have a new resource to help them navigate ... related centers on campus. , ,The Office of Corporate ... , which is to include events, publications and both ... to UW=-Madison faculty, staff and students. , ,Were one ...
Cached Biology Technology:Tech Digest (11/10/2004) 2Sarcasm and rainmaking advice coexist in The Art of the Start 2Sarcasm and rainmaking advice coexist in The Art of the Start 3Sarcasm and rainmaking advice coexist in The Art of the Start 4Sarcasm and rainmaking advice coexist in The Art of the Start 5UW plans entrepreneurship program to link campus resources 2
Polyclonal Antibody to CLAN...
Request Info...
IRF7 Immunogen: Synthetic peptide corresponding to residues E(463) G T Q R E G V S S L D S S S(477) of human IRF7. Storage: -20 C, Avoid Freeze/Thaw Cycles...
Rabbit polyclonal to TetR ( Abpromise for all tested applications). Antigen: Synthetic peptide: AQKLGVEQPTLYWHVKNKR, corresponding to amino acids 31 - 49 of TetR...
Biology Products: