Navigation Links
No entry without protein recycling: RUB researchers discover new coherence in enzyme transport
Date:2/10/2012

The group of Prof. Dr. Ralf Erdmann at the Ruhr-Universitt Bochum (Faculty of Medicine, Department of Systems Biochemistry) discovered a connection of peroxisomal protein import and receptor export. In the Journal of Biological Chemistry, they disclosed that enzymes only get imported into certain cell organelles (peroxisomes) upon coupling of their import to the recycling of their transport protein (receptor).

Multi-functional tool peroxisome

Peroxisomes do not have their own DNA. Thus, all peroxisomal proteins are coded within the nucleus and imported into the peroxisome after their synthesis is completed. The Erdmann lab investigates this process in detail. Peroxisomes contain more than 50 various enzymes in total which e.g. decompose fatty acids and dispose hydrogen peroxide or plasmalogens, the main phospholipid of the white matter of the brain. A disruption of their function does not only cause severe metabolic disorders, it can even lead to death of newborns.

Export signal controls recycling

Dynamic receptors recognize and escort the enzymes destined for the peroxisome to the organelle where they attach to the membrane. Then the receptor-enzyme complex disassembles and the enzyme is transported across the peroxisomal membrane. Afterwards, the receptor is transported from the membrane back to the cytosol. This recycling is controlled by the attachment of the small protein ubiquitin to the receptor, which functions as an export signal.

Modification as a safety barrier

The team of Prof. Dr. Ralf Erdmann studied a certain peroxisomal receptor, which consists of a targeting unit (Pex18p) and an enzyme-binding unit (Pex7p). The scientists discovered that ubiquitin modifies Pex18p in order to enable the receptor to return to the intracellular liquid. Only when the targeting unit of the receptor is exported from the membrane, the import of the cargo-loaded enzyme-binding unit takes place. This result supports the export-driven-import model, previously proposed by the Erdmann group.


'/>"/>

Contact: Dr. Ralf Erdmann
Ralf.Erdmann@rub.de
49-234-322-4943
Ruhr-University Bochum
Source:Eurekalert

Related biology news :

1. Computer order entry systems reduce preventable adverse drug events
2. Entry point for hepatitis C infection identified
3. SIB launches next generation ExPASy, an entry portal to indispensable bioinformatics resources
4. Entry inhibitors show promise as drugs with new MOA for treatment of HBV and HDV infection
5. No-entry zones for AIDS virus
6. Potatoes lower blood pressure in people with obesity and hypertension without increasing weight
7. No future without scarce metals
8. System to deliver organ transplant drug -- without harmful side effects
9. A new method for testing allergenic substances without experimental animals
10. Green routing can cut car emissions without significantly slowing travel time
11. Alternate ending -- living on without telomerase
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/5/2020)... ... ... Regenative Labs has received approval from the Centers for Medicare & Medicaid ... Wharton’s jelly allografts to be assigned a Q code and be approved for application ... jelly allograft product to be recognized as a 361 HCT/P by CMS regulated under ...
(Date:7/31/2020)... , ... July 30, 2020 , ... ... digital therapeutics product portfolio with a near term focus on Type 2 diabetes ... pharma commercialization experience across multiple therapeutic areas and classes. As Chief Commercial Officer, ...
(Date:7/18/2020)... ... July 17, 2020 , ... Commercial launch readiness is ... ability to discover a COVID cure or vaccine, the global economic downturn will only ... pressure is not going away and capturing full value from every product launch is ...
Breaking Biology News(10 mins):
(Date:7/18/2020)... ... July 16, 2020 , ... After research model surgery ... of a great surgery is only the beginning of a successful study, while protecting ... , Join Brad Gien, Global Head of Surgery from Envigo in a ...
(Date:7/18/2020)... Ohio (PRWEB) , ... July 16, 2020 , ... ... data solutions to aid in the early detection and prevention of high-burden diseases, ... to enable US-based hospitals and healthcare organizations to utilize existing data in order ...
(Date:7/10/2020)... ... July 08, 2020 , ... Bode Technology, ... expansion of laboratory operations through its COVID-19 testing service, Bode-CARES . Bode-CARES ... , Bode-CARES provides a turnkey solution that includes a comprehensive collection ...
(Date:7/10/2020)... , ... July 09, 2020 , ... ... 1-phenyl-2-thiourea (PTU) is commonly used to suppress pigment formation in zebrafish embryos, maintaining ... research team led by Dr MA has been using the zebrafish model to ...
Breaking Biology Technology: