Navigation Links
No compromises: JILA's short, flexible, reusable AFM probe
Date:4/9/2014

JILA researchers have engineered a short, flexible, reusable probe for the atomic force microscope (AFM) that enables state-of-the-art precision and stability in picoscale force measurements. Shorter, softer and more agile than standard and recently enhanced AFM probes, the JILA tips will benefit nanotechnology and studies of folding and stretching in biomolecules such as proteins and DNA.

An AFM probe is a cantilever, shaped like a tiny diving board with a small, atomic-scale point on the free end. To measure forces at the molecular scale in a liquid, the probe attaches its tip to a molecule such as a protein and pulls; the resulting deflection of the cantilever is measured. The forces are in the realm of piconewtons, or trillionths of a newton. One newton is roughly the weight of a small apple.

The new probe design, described in ACS Nano,* is the JILA research group's third recent advance in AFM technology. JILA is jointly operated by the National Institute of Standards and Technology (NIST) and University of Colorado Boulder.

The group previously improved AFM position stability by using laser beams to sense motion** and removing the gold coating from long probe tips, or cantilevers, to enhance long-term force stability.*** However, removing the gold reduces the strength of the signal being measured, and using long cantilevers leads to other measurement problems such as slower response to dynamic events like protein unfolding.

The latest modification overcomes these and other issues, improving precision without loss of stability, speed, or sensitivity. JILA researchers used a focused ion beam to cut a hole in the center of a short commercial cantilever and thinned the remaining support structures, thereby reducing the cantilever's stiffness and friction near surfaces. The result is excellent long-term stability and improved short-term precision, respectively, in AFM force measurements.

JILA researchers a
'/>"/>

Contact: Laura Ost
laura.ost@nist.gov
303-497-4880
National Institute of Standards and Technology (NIST)
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Oil and water: An icy interaction when oil chains are short, but steamy when chains are long
2. Researchers create flexible, nanoscale bed of nails for possible drug delivery
3. Robotic arm probes chemistry of 3-D objects by mass spectrometry
4. New probes from Scripps research quantify folded and misfolded protein levels in cells
5. Researchers use genetic signals affecting lipid levels to probe heart disease risk
6. Global Cancer Biomarkers Market 2012-2016 with Agilent Technologies Inc., Gen-Probe Inc. and Astellas Pharma US Inc. Dominating
7. IU-designed probe opens new path for drug development against leading STD
8. Stanford scientists probe abandoned mine for clues about permanent CO2 sequestration
9. Light and nanoprobes detect early signs of infection
10. Light-emitting bioprobe fits in a single cell
11. Listening to cells: Scientists probe human cells with high-frequency sound
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
No compromises: JILA's short, flexible, reusable AFM probe
(Date:12/11/2014)... 09, 2014 Research and Markets ... ( http://www.researchandmarkets.com/research/twhjll/biometrics_market ) has announced the addition ... Region 2015-2019"  report to their offering. ... is advances in technology. With continuous advances in ... to the latest standard that meets the needs ...
(Date:12/11/2014)... N.C. , Dec. 10, 2014  That blood pressure ... quite a while. Hypertension – the medical term for high ... the early 1800s, and the inflatable cuff that,s used in ... doesn,t, however, mean there,s nothing new about hypertension, its triggers ... long-held beliefs about the condition and the best ways to ...
(Date:12/10/2014)... -- You,ve been here before: you desperately need to sign ... site key or the answer to your secret question. What,s ... Today, Hoyos Labs , a digital infrastructure ... put an end to the frustration that comes with usernames, ... leverages a user,s smartphone to acquire his or her biometrics ...
Breaking Biology News(10 mins):Biometrics Market in the APAC Region 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2Research points to need for new approaches to treatment of high blood pressure 2Research points to need for new approaches to treatment of high blood pressure 3Research points to need for new approaches to treatment of high blood pressure 4The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 3
... of the University,s Department of Biology has recently returned from ... Albacet, Spain. The Crocusbank project centres round saffron as ... Its aim is to improve saffron production, a ... of Europe and is both sustainable and of very high ...
... of bacteria, fungi and other microbes that live in our ... down toxins, manufacture some vitamins and essential amino acids, and ... Nature shows that, at 3.3 million, microbial genes ... the human body. Scientists at the European Molecular Biology Laboratory ...
... The 2010 American Society for Microbiology (ASM) Maurice ... Wilburt C. Davison Professor Emeritus, Duke University School of ... on vaccine discovery and development. This award, established in ... pathogenesis, vaccine discovery, vaccine development, and/or control of vaccine-preventable ...
Cached Biology News:Leicester's internationally acclaimed genetics research involved in project into saffron production 2Bacterial balance that keeps us healthy 2
(Date:12/19/2014)... 2014 Today, TiFiber, Inc. ... production facility and future company headquarters in Fort ... new materials that safely and effectively control dangerous ... of its historic, strong support for manufacturing, but ... leading edge, technology-based companies such as TiFiber. ...
(Date:12/19/2014)... Biddeford, ME (PRWEB) December 18, 2014 ... founding director of the Center for Excellence in the ... of New England, has been selected as a member ... He is the first neuroscientist from Maine to receive ... a nonprofit organization supported entirely by the Dana Foundation. ...
(Date:12/19/2014)... (PRWEB) December 18, 2014 iLab Solutions, ... the appointment of Siri Bryant as the new Director ... Director of Core Implementations. These two new leadership positions ... customer service by ensuring that iLab continues to meet ... the last four years, iLab has been deployed at ...
(Date:12/19/2014)... (PRWEB) December 19, 2014 The ... to the rising ageing population and technological innovations ... and nutraceutical industries are catalysing the growth of ... @ http://www.marketsandmarkets.com/Market-Reports/empty-capsules-market-218018190.html , Scope of Report ... as well as new entrants/smaller firms to gauge ...
Breaking Biology Technology:Technology Company TiFiber™ to Establish Production Facility in Fort Smith, Arkansas with Support from Local Investors 2Technology Company TiFiber™ to Establish Production Facility in Fort Smith, Arkansas with Support from Local Investors 3Technology Company TiFiber™ to Establish Production Facility in Fort Smith, Arkansas with Support from Local Investors 4UNE's Ed Bilsky Named Member of Dana Alliance for Brain Initiatives 2UNE's Ed Bilsky Named Member of Dana Alliance for Brain Initiatives 3iLab Solutions Announces Two New Leadership Positions to Meet the Needs of Its Growing Customer Base 2Empty Capsules Market Hit to Reach $1,820 Million by 2019 - New Research Report by MarketsandMarkets 2Empty Capsules Market Hit to Reach $1,820 Million by 2019 - New Research Report by MarketsandMarkets 3Empty Capsules Market Hit to Reach $1,820 Million by 2019 - New Research Report by MarketsandMarkets 4
... & Sullivan European Drug Discovery Product Innovation Award ... its active role in the production of single ... http://www.newscom.com/cgi-bin/prnh/20081117/FSLOGO )These test kits, used in the early ... of drug discovery and development through lead optimisation. ...
... if approved, could potentially reach $1 billion by 2014SEATTLE, ... Inc. (CTI) (NASDAQ and MTA: CTIC) reviewed CTI,s programs ... Northwest Conference on Wednesday, March 18th . Mr. ... of aggressive relapsed non-Hodgkin,s lymphoma (NHL) and OPAXIO for ...
... (Nasdaq: NLTX ), a leading company in ... today announced that, pursuant to Nasdaq Marketplace Rule 4350(b)(1)(B), ... December 31, 2008, included in the Company,s Annual Report ... a going concern qualification from its independent registered public ...
Cached Biology Technology:Frost & Sullivan European Drug Discovery Product Innovation Award Bestowed on Xenometrix AG 2Frost & Sullivan European Drug Discovery Product Innovation Award Bestowed on Xenometrix AG 3Cell Therapeutics Presents Corporate Highlights at Invest Northwest Conference 2Cell Therapeutics Presents Corporate Highlights at Invest Northwest Conference 3Nile Therapeutics Announces Information in Compliance With NASDAQ Marketplace Rule 4350 and Reiterates 2009 Objectives 2Nile Therapeutics Announces Information in Compliance With NASDAQ Marketplace Rule 4350 and Reiterates 2009 Objectives 3
HSD17B3 Immunogen: HSD17B3 (NP_000188, 29 a.a. ~ 120 a.a) partial recombinant protein with GST tag. Storage: -20 C, Avoid Freeze/Thaw Cycles *Available for distribution in the US only...
Rad51, N-terminal...
Phospho-mu-Opioid Receptor (Ser375) Antibody...
Rabbit polyclonal to WWOX8 ( Abpromise for all tested applications). entrezGeneID: 51741 SwissProtID: Q9NZC7-8...
Biology Products: