Navigation Links
Nixing immaturity in red blood cells
Date:5/4/2008

A process of self-digestion called autophagy prompts the maturation of red blood cells. Without a protein called Nix, the cells would not effectively rid themselves of organelles called mitochondria and consequently become short-lived, leading to anemia, said researchers at Baylor College of Medicine in Houston in a report that appears online today in the journal Nature.

Its changed our thinking on autophagy, said Dr. Jin Wang, assistant professor of immunology at BCM and senior author of the report. During autophagy, the cell forms an envelope or vesicle around components of the cell that need to be degraded and removed. The vesicle then fuses with a cellular component called a lysosome that degrades its contents. The inclusion of components in the cell by autophagy vesicles was generally considered to be nonspecific.

This is not a random process, said Wang. Nix is instructing the cell to get rid of these mitochondria.

Nix accomplishes this task by disrupting the mitochondrial membrane potential (represented by difference in voltage across the inner membrane of the mitochondria. The interior is negative and the outside positive. The difference generates a force that drives the synthesis of ATP, the cells energy molecule).

We think the finding is not limited to the clearance of mitochondria in red blood cells, said Wang. When other cells get old or stressed, their organelles may become damaged and need to be cleared by autophagy for quality control. If the cells lack such quality controls, they might have problems that result in aging, cancer and neurodegenerative diseases.

It helps get rid of old or damaged mitochondria, he said. It is a way to keep the cell functioning without going through programmed cell death (apoptosis).

Such specific regulation of autophagy may also be important for cell types in the muscle, brain and pancreas, said Dr. Min Chen, assistant professor of immunology at BCM and a co
'/>"/>

Contact: Dipali Pathak
pathak@bcm.edu
713-798-4710
Baylor College of Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. UF scientists discover compound that could lead to new blood pressure drugs
2. Genetic breakthrough explains dangerously high blood glucose levels
3. UCLA stem cell researchers create heart and blood cells from reprogrammed skin cells
4. Hyperviscous fluids: Better treatment for severe blood loss
5. Clumps of red and white blood cells may contribute to sickle cell disease
6. Menstrual blood -- a valuable source of multipotential stem cells?
7. Effective cancer immune therapy through order in the blood vessels
8. Bloodless worm sheds light on human blood, iron deficiency
9. Mental stress reduces blood flow to the heart in patients with gene variation
10. Backpack straps can decrease blood flow in the shoulder and arm
11. Yale study shows how rare genes have big impact on blood pressure
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/6/2015)... , Apr. 6, 2015 NXT-ID, Inc. ... a biometric authentication company focused on the growing ... filed provisional patent 62/143028 for MINIATURE, ... ENERGY TRANSFER  NXT-ID introduces a new ... This patent surrounds the use of miniature antenna ...
(Date:4/1/2015)... -- NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or the ... mobile commerce market, announces the second shipment of a ... early access pre-order customers. Feedback from ... including Walmart, Target, AT&T, Dunkin, Donuts, Stop & Shop ... all outlets and very easy to use. Several users ...
(Date:3/26/2015)... TORONTO , March 26, 2015 ... premier family, social, recreation and athletic club, today announced ... designed to allow freedom of movement for members and ... "Following a comprehensive process, we selected FST,s IMID ... sophistication and convenience for our members and staff, in ...
Breaking Biology News(10 mins):NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 2NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 3NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 4NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 2NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 3NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 4Granite Club First Private Club in North America to Implement FST Biometrics Secure Access Solution, as Part of Multi-million Dollar Expansion 2
... This release is available in Spanish . ... ruminants ward off damaging gastrointestinal nematodes that can cause illness ... Animal scientist Joan Burke at the ARS Dale Bumpers Small ... several universities, has patented formulations of Sericea lespedeza , ...
... lizards supports an old idea about how species can ... and biologists have speculated that these "morphs" could be ... types of individuals within the same population could eventually ... conducted by researchers at the University of California, Santa ...
... perceive even the slightest vibration and touch of the ... the mediation of these sensations. Ion channels are pores ... external signals. Mechanosensitive ion channels open at the slightest ... the cell membrane, which causes an electrical current until ...
Cached Biology News:Forage plant wards off ruminant gastrointestinal nematode 2Evolutionary game of rock-paper-scissors may lead to new species 2Evolutionary game of rock-paper-scissors may lead to new species 3Evolutionary game of rock-paper-scissors may lead to new species 4MDC researchers link protein tether to touch perception 2
(Date:4/30/2015)... The following is an open letter sent April ... Blood Corp (NYSE: CO ) from Jayhawk Capital. ... directors of China Cord Blood Corp (" China Cord ") ... share from Golden Meditech Holdings Co Ltd ("Golden Med"). Certainly, ... benefit Golden Med and Mr. Kam, the Chairman of both ...
(Date:4/30/2015)...  The Paul G. Allen Family Foundation announced today ... six groups of researchers with projects at the frontier ... growing mature human brain cells in the laboratory. The ... over three years.  "This new cohort ... significant because the field of neuronal maturation is at ...
(Date:4/30/2015)... Calif. , April 30, 2015  Asterias Biotherapeutics, ... the emerging field of regenerative medicine, today announced that ... on Thursday, May 7, 2015 after the close of ... conference call and webcast on Thursday, May 7, 2015 ... discuss the results and recent corporate developments. ...
(Date:4/30/2015)... WuXi PharmaTech (Cayman) Inc. ("WuXi" or the "Company") (NYSE: ... provider, today announced that its board of directors has ... 2015, from a consortium (the "Consortium") led by Dr. ... chief executive officer of the Company, and Ally Bridge ... "Transaction") involving the acquisition of all outstanding shares of ...
Breaking Biology Technology:April 30, 2015 Open Letter to the Board of China Cord Blood Corp from Jayhawk Capital 2April 30, 2015 Open Letter to the Board of China Cord Blood Corp from Jayhawk Capital 3April 30, 2015 Open Letter to the Board of China Cord Blood Corp from Jayhawk Capital 4April 30, 2015 Open Letter to the Board of China Cord Blood Corp from Jayhawk Capital 5The Paul G. Allen Family Foundation Awards $7.5 Million To Study Brain Cell Growth And Development 2The Paul G. Allen Family Foundation Awards $7.5 Million To Study Brain Cell Growth And Development 3The Paul G. Allen Family Foundation Awards $7.5 Million To Study Brain Cell Growth And Development 4The Paul G. Allen Family Foundation Awards $7.5 Million To Study Brain Cell Growth And Development 5Asterias Biotherapeutics to Report First Quarter Results on May 7, 2015 2Asterias Biotherapeutics to Report First Quarter Results on May 7, 2015 3WuXi PharmaTech Announces Receipt of Proposal 2WuXi PharmaTech Announces Receipt of Proposal 3WuXi PharmaTech Announces Receipt of Proposal 4WuXi PharmaTech Announces Receipt of Proposal 5WuXi PharmaTech Announces Receipt of Proposal 6
... REDWOOD CITY, Calif., Sept. 15 Cardica, Inc.,(Nasdaq: ... million milestone,payment from Cook Medical (Cook) for the successful ... in the heart known as,patent foramen ovales (PFO), a ... of the general population., "Patients with PFO may ...
... China Biopharma,Inc. (OTC Bulletin Board: CBPC) announced today that ... State of Delaware an amendment to its Certificate,of Incorporation ... China,Biopharma,s common stock ("Common Stock") will begin trading on ... symbol CHBO., By unanimous written consent dated July ...
... /Xinhua-PRNewswire/ -- Sinovac Biotech Ltd. (Amex:,SVA), a leading ... of clinical trials in Ukraine for its inactivated ... are being conducted by,Biolik Biopharmaceutical Company, a vaccine ... in the Country. Biolik will,also market and distribute ...
Cached Biology Technology:Cardica Receives $1 Million Milestone Payment From Cook Medical for Development of Heart Defect Closure Device 2Cardica Receives $1 Million Milestone Payment From Cook Medical for Development of Heart Defect Closure Device 3Cardica Receives $1 Million Milestone Payment From Cook Medical for Development of Heart Defect Closure Device 4China Biopharma Effects 1 for 100 Reverse Stock Split 2China Biopharma Effects 1 for 100 Reverse Stock Split 3Sinovac Initiates Clinical Trials for Inactivated Hepatitis A Vaccine in Ukraine 2Sinovac Initiates Clinical Trials for Inactivated Hepatitis A Vaccine in Ukraine 3