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Nitrates in vegetables protect against gastric ulcers
Date:5/7/2008

e food ingested. Two such important defence mechanisms are the stomach's constant renewal of the mucous layer that covers the mucous membrane and its maintenance of a stable blood flow in the mucous membrane. The nitric oxide widens the blood vessels in the mucous membrane, thus increasing the blood flow and regulating elimination of the important mucus. Together, these factors lead to a more resistant mucous membrane.

Using animal models Joel Petersson and his colleagues have shown that nitrate additives in food protect against both gastric ulcers and the minor damage that often occurs in the gastrointestinal tract as a result of ingestion of anti-inflammatory drugs.

"These sorts of drugs are very common in the event of pain and inflammation. They have the major disadvantage of causing a large number of serious side effects in the form of bleeding and ulcers in the gastrointestinal tract. With the aid of a nitrate-rich diet you can thus avoid such damage," he explains.

The thesis also shows that the bacteria in the oral cavity are very important to the process of nitrates in food protecting the stomach's mucous membrane. This has been examined in that rats have been given nitrate-rich feed, whereby some of them have also simultaneously received an antibacterial oral spray. When these rats were then given anti inflammatory drugs, damage to the mucous membrane only occurred in the ones that had received the oral spray. In the latter the nitrates no longer had a protective effect on the mucous membrane, as the oral spray had killed the important bacteria that normally convert nitrates into nitrites.

"This shows how important our oral flora is. The fact that these bacteria are not just involved in our oral hygiene but also play an important role in the normal functions of the gastrointestinal tract is not entirely new. It is currently an important issue, as antibacterial mouthwashes have become more and more common. If a mouthwash
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Contact: Joel Petersson
Joel.Petersson@mcb.uu.se
46-070-418-5375
Uppsala University
Source:Eurekalert

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