Navigation Links
Nicotine found to inhibit DNA-strand break caused by a certain carcinogen in smoke
Date:7/27/2014

says. Clearly, therefore, there are limitations to assessing individual toxicants in tobacco smoke and other complex mixtures.

Typically, tobacco smoke carcinogens are evaluated individually, and NNK carcinogenicity has been clearly established in systems using doses of a single chemical. However, these findings illustrate that the risk associated with a particular toxicant may be relative to the presence of other chemicals.

Moreover, the findings raise an interesting and potentially controversial question regarding unanticipated effects of reducing nicotine in tobacco products: whether such reduction could lead to an increase of one form of nitrosamine-dependent DNA damage.

However, the researchers caution that the study was on immortalized liver cells not those of the lung, which express different CYP enzymes. Furthermore, there is no evidence that nicotine or cotinine have a protective effect on DNA strand break in vivo. They also point out that strand breaks are only one of many mechanisms through which NNK can damage DNA and those have not been evaluated in the study. The next step is to repeat the experiment using human lung epithelial cells.


'/>"/>

Contact: Marina Murphy
marina_murphy@bat.com
44-077-111-50135
R&D at British American Tobacco
Source:Eurekalert

Page: 1 2

Related biology news :

1. Fetal exposure to nicotine increases long-term risk of obesity
2. Maternal stress hormones and maternal smoking increase daughters risk of nicotine dependence
3. Nicotine drives cell invasion that contributes to plaque formation in coronary arteries
4. Albert Einstein College of Medicine receives grant from the Michael J. Fox Foundation to fund drug discovery project targeting Parkinsons
5. NYSCF partners with Beyond Batten Disease Foundation to fight juvenile Batten disease
6. New planthopper species found in southern Spain
7. A region and pathway found crucial for facial development in vertebrate embryos
8. Damon Runyon Cancer Research Foundation grants fellowship awards to 16 young scientists
9. BGI reports a novel gene for salt tolerance found in wild soybean
10. BrightFocus Foundation announces 55 new grantees in Alzheimers and vision research
11. Bacteria found in bladders of healthy women differ from those in women with incontinence
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/29/2014)... of Texas at Arlington research team says recently identified ... their lab could open doors for homeland security and ... in the Oct. 1 issue of Optics Letters ... co-authors describe a new method to fabricate transparent nanoscintillators ... until a transparent ceramic is formed. A scintillator ...
(Date:9/29/2014)... University have concluded that nondigestible compounds in apples ... prevent disorders associated with obesity. The study, thought ... in apple cultivars grown in the Pacific Northwest, ... Food Chemistry ., "We know that, in ... nondigestible compounds but there are differences in varieties," ...
(Date:9/29/2014)... scientists have found compounds that boost liver detoxification enzymes ... unlikely placethe crushed seeds left after oil extraction from ... bioactive compounds in Camelina sativa seed, also ... of phytochemicals that work together synergistically far better than ... nutritional supplement because its bioactive ingredients increase the liver,s ...
Breaking Biology News(10 mins):UT Arlington researchers develop new transparent nanoscintillators for radiation detection 2UT Arlington researchers develop new transparent nanoscintillators for radiation detection 3An apple a day could keep obesity away 2New way to detox? 'Gold of Pleasure' oilseed boosts liver detoxification enzymes 2
... Society for Microbiology (ASM) sanofi-aventis ICAAC Award will ... of Oxford, United Kingdom and Mahidol University, Bangkok, ... Units, Bangkok. Supported by sanofi-aventis, the award ... of new agents, investigation of antimicrobial action or ...
... for Microbiology (ASM) ICAAC Young Investigator Award will be ... Texas A & M University, College Station. Sponsored by ... scientists for research excellence in microbiology and infectious diseases. ... pathogen, has a defined sexual cycle with two mating ...
... -- Engineers at Ohio State University have found a way ... someday replace gasoline in automobiles. The process improves on ... tank. Normally, bacteria could only produce a certain amount ... every liter of water in the tank -- before the ...
Cached Biology News:Researchers boost production of biofuel that could replace gasoline 2
(Date:9/30/2014)... (PRWEB) September 30, 2014 The custom ... ISPE Boston Product Show 2014. The Boston Area Chapter ... the 23rd annual, day-long event for Wed., Oct. 1 ... promises to be the largest in ISPE Boston’s long ... upward of 3,000 attendees expected. , HOLLOWAY AMERICA ...
(Date:9/30/2014)... SoundConnect, an award ... dedicated to supporting business communication solutions, including business ... a carrier services specialist has joined ... connected and productive at all times. This growth ... businesses to cloud communications services. On a ...
(Date:9/30/2014)... On September 11, Pharma IQ conducted an ... of a session that he will lead on “Stem Cells” ... February 17-18, 2015 in London. In the interview posted ... Sherley to respond to several questions on the current state ... stem cell toxicity, and future trends in the use of ...
(Date:9/30/2014)... (PRWEB) September 30, 2014 Whitehouse ... been chosen by the Parenteral Drug Association (PDA) ... and 19, 2014) on container closure integrity testing. This ... integrity test methods and philosophies detailed in the recently ... Evaluation. The course will span container closure ...
Breaking Biology Technology:HOLLOWAY AMERICA to Exhibit at ISPE Boston Product Show 2014 2HOLLOWAY AMERICA to Exhibit at ISPE Boston Product Show 2014 3SoundConnect Expands Carrier Services Division 2Adult Stem Cell Technology Center, LLC Director James L. Sherley Discusses Stem Cell Toxicology 2Adult Stem Cell Technology Center, LLC Director James L. Sherley Discusses Stem Cell Toxicology 3Adult Stem Cell Technology Center, LLC Director James L. Sherley Discusses Stem Cell Toxicology 4Whitehouse Laboratories to Partner with PDA for Educational Course on Container Closure Integrity Testing 2Whitehouse Laboratories to Partner with PDA for Educational Course on Container Closure Integrity Testing 3Whitehouse Laboratories to Partner with PDA for Educational Course on Container Closure Integrity Testing 4
... 4 Wyeth (NYSE: WYE ),announced today ... 2008 Global,Pharmaceutical, Biotechnology and Medical Device Conference on ... Presenting for Wyeth will be,Geno Germano, President, U.S. ... presentation will be webcast live for investors at, ...
... Technologies, Inc.,(Nasdaq: EMIS ), a biopharmaceutical company that ... using its eligen(R) technology,today announced that the company will ... 12, 2008 at the Waldorf Astoria Hotel in New ... Officer of,Emisphere, will present for the company at 2:45 ...
... Calif., Feb. 4 AMDL, Inc. (Amex:,ADL), ... Shenzhen,Jiangxi, and Jilin, China, through its wholly ... international biopharma company that,together with Jade, engages ... pharmaceutical, health care and diagnostic products. The,Company ...
Cached Biology Technology:Wyeth to Present at the Merrill Lynch 2008 Global Pharmaceutical, Biotechnology and Medical Device Conference 2Emisphere Technologies to Present at BIO CEO & Investor Conference on February 12 2AMDL Receives a Significant Updated Appraisal of Its JJB China Production Facilities 2
...
Immunogen: Recombinant rabbit tryptophan hydroxylase, isolated as inclusion bodies from E. coli and purified by preparative SDS-PAGE. Storage: -20 C, Avoid Freeze/Thaw Cycles...
Src cDNA Expression Kit (wild type)...
...
Biology Products: