Navigation Links
Nicotine does not promote lung cancer growth in mouse models
Date:4/4/2011

ORLANDO, Fla. Nicotine at doses similar to those found in most nicotine replacements therapies did not increase lung cancer tumor incidence, frequency or size, according to results of a mouse study presented at the AACR 102nd Annual Meeting 2011, held here April 2-6.

"If you take our data and combine it with epidemiological data from Europe, even in people who quit smoking and maintain the use of nicotine replacement therapy for months or years, there does not appear to be increased lung cancer incidence," said Phillip A. Dennis, M.D., Ph.D., senior investigator at the medical oncology branch of the National Cancer Institute. "This suggests that nicotine replacement therapy is probably safe and is certainly safer than smoking."

According to Dennis, about 20 percent of all smokers are truly addicted to tobacco. In these people, the use of nicotine replacement therapy has markedly helped them to quit smoking. The current Food and Drug Administration indication for most nicotine replacement therapies, such as a nicotine patch, is limited to 10 to12 weeks.

There is a subset of smokers who will need to stay on nicotine replacement therapy longer in order to appease addiction, according to Dennis. However, expanding the use of this therapy is controversial. Research to date has linked nicotine to cancer in various ways, including laboratory studies that indicate nicotine promotes the growth or spread of tumor cells or that it helps transform normal lung airway cells into cancerous cells, according to Dennis.

Therefore, the researchers conducted a study in mice to determine if nicotine had any tumor-promoting effects. Three groups of mice were administered nicotine in drinking water for up to 12 weeks.

In the first group, the mice were administered three weekly injections of NNK, a known tobacco carcinogen, prior to receiving nicotine. The second group of mice was genetically engineered to have activation of the KRAS onco
'/>"/>

Contact: Jeremy Moore
Jeremy.Moore@aacr.org
267-646-0557
American Association for Cancer Research
Source:Eurekalert

Page: 1 2

Related biology news :

1. Study links nicotine with breast cancer growth and spread
2. Researchers find link between nicotine addiction and autism
3. Nicotine activates more than just the brains pleasure pathways
4. Skin color clue to nicotine dependence
5. Simple drug treatment may prevent nicotine-induced SIDS: Study
6. Increased nicotine levels detected in those who light-up earlier
7. Are bees also addicted to caffeine and nicotine?
8. Tobacco companys new, dissolvable nicotine products could lead to accidental poisoning
9. GUMC to develop smoking cessation aids based on unconventional nicotine addiction theory
10. Tobacco and its evil cousin, nicotine? Theyre good -- as a pesticide!
11. Team awarded $7.5 million to identify potential drug candidates to treat nicotine addiction
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/14/2015)... YORK , April 14, 2015  HYPR ... IDentity Online (FIDO ® ) Alliance tm , ... specifications. FIDO members commit to share technology and ... methods that are interoperable, more secure and private, ... enable biometric identity verification that protects sensitive user ...
(Date:4/13/2015)... 2015 According to a ... Market Forecast & Opportunities, 2020", the global biometrics market ... 14% till 2020. The biometrics market is garnering ... and review of biometric management systems. The constant ... with greater efficiency, are resulting in increasing installation ...
(Date:4/10/2015)... Research and Markets ( http://www.researchandmarkets.com/research/cjk4gb/security ) has ... - NEC" report to their offering. ... to supply a range of IT security management and ... on the development of a Big Data and cloud ... Asia-Pacific region is a core ...
Breaking Biology News(10 mins):HYPR Corp. Joins the FIDO Alliance 2HYPR Corp. Joins the FIDO Alliance 3Global Biometrics Market to Cross US$ 21 Billion by 2020: TechSci Research 2NEC Security Competitive Profile 2015 2
... As the desert Southwest becomes hotter and drier, ... dominated by mesquite trees, such as Prosopis velutina, and ... researchers has found. In a "leaf-to-landscape" approach, the ... across entire ecosystems to quantify how well grasslands, compared ...
... Bonheur Professor Russell Chesney, M.D. believes he knows what was ... Christmas Carol." Based on detailed descriptions of both the ... hypothesizes that Tiny Tim suffered from a combination of rickets ... March 5 edition of Archives of Pediatrics and Adolescent ...
... now 20 years old, and its network of protected areas, known ... start, the network now includes some 26 000 protected sites and ... significant areas of sea. It is widely considered to be the ... criteria. The review has been published in the newly ...
Cached Biology News:Mesquite trees displacing Southwestern grasslands 2Mesquite trees displacing Southwestern grasslands 3Mesquite trees displacing Southwestern grasslands 4Mesquite trees displacing Southwestern grasslands 5Building the European Union's Natura 2000 -- the largest ever network of protected areas 2
(Date:5/20/2015)... 20, 2015 Research and Markets ( ... "Top Technologies in HW_Technical Insights" report to their ... evaluated technology trends in the Health and Wellness sector ... to have an impact in the year 2015. The ... top 10 health and wellness technologies that are anticipated ...
(Date:5/20/2015)... , May 20, 2015  Select Medical ... the Federal Trade Commission granted early termination of ... Improvements Act of 1976, as amended, applicable to ... Acquisition Corporation, a joint venture that Select has ... As previously announced, MJ Acquisition Corporation ...
(Date:5/20/2015)... 20, 2015 Agricultural firm H.J. Baker ... its acquisition of Tiger-Sul. Since the purchase of ... Canada) in May 2005, H.J. Baker has leveraged the ... into a comprehensive portfolio of product offerings and solutions ... Baker and the innovation of Tiger-Sul, transforming the company ...
(Date:5/20/2015)... , May 20, 2015  Cypher Genomics, ... a collaboration with Celgene Corporation to apply Cypher,s ... biomarkers that associate with patient response to innovative ... intended to help accelerate patient access to the ... in clinical research and development and potentially inform ...
Breaking Biology Technology:Top Technologies in the Health and Wellness Industry 2015 2Select Medical Corporation's Proposed Acquisition of Concentra Inc. through Joint Venture with Welsh Carson Receives Antitrust Clearance 2Agricultural Firm H.J. Baker & Bro., Inc., Celebrates 10 Years Since Acquisition Of Tiger-Sul 2Agricultural Firm H.J. Baker & Bro., Inc., Celebrates 10 Years Since Acquisition Of Tiger-Sul 3Cypher Genomics Collaborates with Celgene Corporation to Identify Novel Genomic Biomarkers 2
... , SAN DIEGO, Nov. 24, 2009 Arena Pharmaceuticals, ... company is scheduled to present at the Piper Jaffray 21st Annual ... Time (8:30 a.m. Pacific Time) at the New York Palace Hotel ... Officer, is scheduled to provide an overview of the company, including ...
... , BOZEN, Italy, ... formed a new Canadian joint venture with a group ... under the,name Health Robotics Canada, Inc. and will market, ... concept, which includes the,revolutionary product offerings i.v.STATION(TM), i.v.SOFT(TM), and ...
... ... Abstracts Service (CAS), the global expert on chemical information, reports that China,s ... in chemistry. China trailed Japan,s patent office, the World Intellectual Property Organization ... than a decade, but passed the USPTO in 2005, WIPO in 2006, ...
Cached Biology Technology:Arena Pharmaceuticals to Present at the Piper Jaffray 21st Annual Health Care Conference 2Arena Pharmaceuticals to Present at the Piper Jaffray 21st Annual Health Care Conference 3Health Robotics Continues its Global Expansion With December 09 ASHP's Launch of Joint Venture in Canada 2Health Robotics Continues its Global Expansion With December 09 ASHP's Launch of Joint Venture in Canada 3China Leads All Nations in Publication of Chemical Patents According to CAS, the World's Most Authoritative Publisher of Chemical Information 2China Leads All Nations in Publication of Chemical Patents According to CAS, the World's Most Authoritative Publisher of Chemical Information 3
Mouse monoclonal [6911] to E. coli K99 pilus ( Abpromise for all tested applications)....
...
... HyPer is the first fully genetically ... detection of intracellular hydrogen peroxide (H2O2), one ... Developed on the basis of yellow fluorescent ... Escherichia coli protein OxyR (OxyR-RD), HyPer demonstrates ...
Alexa Fluor 647 anti-mouse Qa-2...
Biology Products: