Navigation Links
Nicotine does not promote lung cancer growth in mouse models
Date:4/4/2011

ORLANDO, Fla. Nicotine at doses similar to those found in most nicotine replacements therapies did not increase lung cancer tumor incidence, frequency or size, according to results of a mouse study presented at the AACR 102nd Annual Meeting 2011, held here April 2-6.

"If you take our data and combine it with epidemiological data from Europe, even in people who quit smoking and maintain the use of nicotine replacement therapy for months or years, there does not appear to be increased lung cancer incidence," said Phillip A. Dennis, M.D., Ph.D., senior investigator at the medical oncology branch of the National Cancer Institute. "This suggests that nicotine replacement therapy is probably safe and is certainly safer than smoking."

According to Dennis, about 20 percent of all smokers are truly addicted to tobacco. In these people, the use of nicotine replacement therapy has markedly helped them to quit smoking. The current Food and Drug Administration indication for most nicotine replacement therapies, such as a nicotine patch, is limited to 10 to12 weeks.

There is a subset of smokers who will need to stay on nicotine replacement therapy longer in order to appease addiction, according to Dennis. However, expanding the use of this therapy is controversial. Research to date has linked nicotine to cancer in various ways, including laboratory studies that indicate nicotine promotes the growth or spread of tumor cells or that it helps transform normal lung airway cells into cancerous cells, according to Dennis.

Therefore, the researchers conducted a study in mice to determine if nicotine had any tumor-promoting effects. Three groups of mice were administered nicotine in drinking water for up to 12 weeks.

In the first group, the mice were administered three weekly injections of NNK, a known tobacco carcinogen, prior to receiving nicotine. The second group of mice was genetically engineered to have activation of the KRAS onco
'/>"/>

Contact: Jeremy Moore
Jeremy.Moore@aacr.org
267-646-0557
American Association for Cancer Research
Source:Eurekalert

Page: 1 2

Related biology news :

1. Study links nicotine with breast cancer growth and spread
2. Researchers find link between nicotine addiction and autism
3. Nicotine activates more than just the brains pleasure pathways
4. Skin color clue to nicotine dependence
5. Simple drug treatment may prevent nicotine-induced SIDS: Study
6. Increased nicotine levels detected in those who light-up earlier
7. Are bees also addicted to caffeine and nicotine?
8. Tobacco companys new, dissolvable nicotine products could lead to accidental poisoning
9. GUMC to develop smoking cessation aids based on unconventional nicotine addiction theory
10. Tobacco and its evil cousin, nicotine? Theyre good -- as a pesticide!
11. Team awarded $7.5 million to identify potential drug candidates to treat nicotine addiction
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... DUBLIN , Dec. 16, 2014 Research and Markets ... of the "Global Chemical Sensor Market 2015-2019" ... http://photos.prnewswire.com/prnh/20130307/600769 One major trend upcoming in ... in biomedical applications. Chemical sensors help in recording of ...
(Date:12/11/2014)... DUBLIN , Dec. 09, 2014 Research and Markets ... ( http://www.researchandmarkets.com/research/twhjll/biometrics_market ) has announced the addition ... 2015-2019"  report to their offering. One ... technology. With continuous advances in technology, it is important ...
(Date:12/11/2014)... Minn. , Dec. 10, 2014  Data Sciences ... monitoring, has released a new series of digital ... preclinical toxicology researchers. M series, part of the ... collect the best possible physiologic data when incorporating ...
Breaking Biology News(10 mins):Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2Biometrics Market in the APAC Region 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2New telemetry implants expected to change how large animal toxicology studies are conducted 2
... voices is second nature to humans. Certain primates also ... social groups are also able to do so, however, ... for meerkats. They coordinate their activities with calls, such ... for instance, and thus stick together as a group. ...
... publishing workflow of eight journals published by Pensoft has ... data archiving for data files associated with articles in these journals. ... the online editorial management platform, Pensoft Journal System (PJS). The ... MycoKeys , BioRisk , NeoBiota , Nature Conservation ...
... Studies have estimated that converting manure from the 95 million ... equal to 8 billion gallons of gasoline, or 1% of ... and more farmers and communities are interested in generating renewable ... information on the economic feasibility and sustainability of such programs. ...
Cached Biology News:Meerkats recognize each other from their calls 2Data publishing in Pensoft journals integrated with the Dryad Data Repository 2Does converting cow manure to electricity pay off? 2
(Date:1/22/2015)... SAN DIEGO , Jan. 22, 2015   ... company, and Sequenom, Inc. (NASDAQ: SQNM ... a development agreement for next generation noninvasive prenatal ... Cypher,s genome interpretation technology, called Mantis™, to advance ...
(Date:1/22/2015)... Jan. 22, 2015   GenoSpace , a precision medicine software ... enable the broad use of genomic, imaging and other biomedical ... of Michelle Munson , CEO of Aspera, an IBM ... Logo - http://photos.prnewswire.com/prnh/20150122/170713 "We are ...
(Date:12/25/2014)... The report “Service Quality Management and Telco ... Type - Global Advancements, Worldwide Forecasts & Analysis (2014-2019)” ... and forecasting of revenues. , Browse 152 market ... in-depth TOC on “Service Quality Management (SQM) and Telco ...
(Date:12/24/2014)... NEW YORK , Dec. 24, 2014 PlasmaTech Biopharmaceuticals, ... in critical areas, announced the closing of an underwritten public ... purchase up to an aggregate 3,500,000 shares of common stock, ... per warrant.  The warrants have a per share exercise price ...
Breaking Biology Technology:Cypher Genomics and Sequenom Announce Development Agreement 2Cypher Genomics and Sequenom Announce Development Agreement 3Cypher Genomics and Sequenom Announce Development Agreement 4GenoSpace Expands Board with Appointment of Michelle Munson 2Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 2Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 3Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 4PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 2PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 3
... MDCT Sub-study to be Released Concurrent with AHA PresentationSAN ... VIAP ), a biotechnology company focused on the ... metabolic disease, today announced that an abstract on the ... accepted for a poster presentation at the American Heart ...
... Intercell AG (VSE: ICLL) today announced that it ... U.S. Food and Drug Administration,s (FDA) approval of IXIARO(R), ... (JE). The initial target for use of Intercell,s vaccine ... U.S. market - will be adult travelers and military ...
... Inc. announced that its wholly-owned subsidiary, Innocoll Pharmaceuticals, has ... Sponge for the management of painful wounds. It ... suffer from chronic wounds (venous stasis ulcers, pressure ulcers, ... chronic wounds do not heal within 5 years. ...
Cached Biology Technology:VIA Pharmaceuticals to Present Poster at AHA Arteriosclerosis, Thrombosis and Vascular Biology Conference 2009 2VIA Pharmaceuticals to Present Poster at AHA Arteriosclerosis, Thrombosis and Vascular Biology Conference 2009 3VIA Pharmaceuticals to Present Poster at AHA Arteriosclerosis, Thrombosis and Vascular Biology Conference 2009 4Intercell to Host Conference Call and Webcast Today on FDA Approval of IXIARO(R) Japanese Encephalitis Vaccine 2Intercell to Host Conference Call and Webcast Today on FDA Approval of IXIARO(R) Japanese Encephalitis Vaccine 3Innocoll, Inc. Files 510 (k) Application for CollaRx Lidocaine Sponge 2
... , Galaxy LIMS, Sophisticated Bioinformatics , Proprietary ... ,We offer individual sample sequencing of PCR ... single or double strand publication quality. ... of interest is 1.3 to 7 kilobytes ...
Shotgun library construction and high-throughput DNA sequencing of microbial genomes, BACs, adenoviruses, phosmids and cosmids. LIMS tracking utilizing Geospiza's Finch system....
...
... Sciences can provide custom microplate coating using advanced automated high ... of plate formats. We can also accommodate virtually any lot ... 0.5-320 L):, , 8 ... well microplate, 384 well microplate, ...
Biology Products: