Navigation Links
Nicotine activates more than just the brain's pleasure pathways
Date:1/22/2009

Durham, N.C. Duke University Medical System researchers have discovered there are differing taste pathways for nicotine, which could provide a new approach for future smoking-cessation products.

"We learned some of nicotine's secrets," said Albino Oliveira-Maia, M.D., Ph.D., a postdoctoral fellow of the Duke Department of Neurobiology. "This is the first study to explore both the peripheral taste pathways activated by nicotine, and how these pathways are integrated in sensory areas of the brain." The peripheral nervous system refers to nerves that are outside of the brain and spinal cord.

Using genetic engineering and measurements of nervous system activity in mice, the researchers found that nicotine sends signals directly to the brain's sensory systems by several pathways, similar to the way taste is perceived.

These findings complement what is known about the effects of nicotine in the dopamine pathway. This is the classic pleasure pathway in the brain, much studied by addiction experts. "Our study in no way contradicts prior findings about nicotine and dopamine," Oliveira-Maia said. "Our findings add to what is known and suggest new approaches for further study."

The findings appeared in the PNAS Early Edition slated for January 19.

"One reason that our findings are interesting is because they relate to previous work that looked at humans with lesions in the insula region of the brain they had an easier time giving up cigarettes than most people," Oliveira-Maia said. "We found that a part of the insula, the gustatory cortex, has robust responses to nicotine and a capacity to integrate diverse peripheral information to create a unique sensory representation for nicotine."

One taste pathway the Duke researchers uncovered involves nicotinic acetylcholine receptors (nAChR), which scientists previously proposed were taste receptors for nicotine. The researchers found a previously unknown link bet
'/>"/>

Contact: Mary Jane Gore
mary.gore@duke.edu
919-660-1309
Duke University Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers find link between nicotine addiction and autism
2. Study links nicotine with breast cancer growth and spread
3. New genetic research into nicotine addiction shows promise for personalized treatment
4. Nicotine may accelerate atherosclerosis, may be as dangerous as tar
5. Gene therapy protocol at UCSD activates immune system in patients with leukemia
6. Rice University psychologist finds womens brains recognize, encode smell of male sexual sweat
7. Old and young brains rely on different systems to remember emotional content
8. The satellite navigation in our brains
9. Big brains arose twice in higher primates
10. Brains R Us: Neuroscience and education town hall
11. From brains to behavior: Cold Spring Harbor Protocols features methods for neuroscience research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/16/2014)... Center for Children,s Environmental Health at the Mailman School ... association between childhood asthma and prenatal exposure to two ... Results appear online in the journal Environmental Health ... during pregnancy to higher levels of the chemicals, butylbenzyl ... percent and 78 percent increase in risk of developing ...
(Date:9/16/2014)... Johns Hopkins neuroscientists have discovered the "molecular brakes" that ... ear cochleas of mice. These "hair cells" translate sound ... brain and are interpreted as sounds. If the arrangement ... , A summary of the research will be published ... 16. , "The proteins Hey1 and Hey2 act as ...
(Date:9/16/2014)... has its own bacterial identity. That,s the conclusion of ... who studied the genetic fingerprints of bacteria on 57 ... "This study demonstrates for the first time that host ... strategies possess very different microbial communities on their leaves," ... researcher in the UO,s Institute of Ecology and Evolution ...
Breaking Biology News(10 mins):Phthalates heighten risk for childhood asthma 2Phthalates heighten risk for childhood asthma 3Hey1 and Hey2 ensure inner ear 'hair cells' are made at the right time, in the right place 2Microbiome research shows each tree species has a unique bacterial identity 2
... a common vaginal infection linked to preterm birth appears ... to a University of Pittsburgh School of Medicine study ... Infectious Diseases Society for Obstetrics and Gynecology in Boston. ... risk of preterm birth goes up, said Hyagriv Simhan, ...
... -- The striking differences between humans and chimps arent so much ... but in the way those genes are used, according to new ... the same set of notes being played in very different ways. ... and other primates those involving brains and diet gene ...
... motor in cochlea hair cells dominates the process of ... the cilia atop those cells dominates the response in ... cells in the inner ear amplify sound in mammals ... bouncing cell bodies rather than vibrating, hair-like cilia, according ...
Cached Biology News:Risk of common vaginal infection linked to preterm birth appears higher for blacks 2Gene regulation, not just genes, is what sets humans apart 2Gene regulation, not just genes, is what sets humans apart 3St. Jude study solves mystery of mammalian ears 2St. Jude study solves mystery of mammalian ears 3
(Date:9/18/2014)... for computing may have just taken an encouraging step ... led by chemist Stephen O,Brien have discovered new complex ... Combining both properties is very exciting scientifically for the ... devices that might ultimately be designed, in logic circuits ... material, however, has proved difficult until now. , Using ...
(Date:9/17/2014)... INCLINE VILLAGE, Nev. , Sept. 17, 2014  PDL ... notified by its independent registered accounting firm, Ernst & Young ... The resignation was confirmed in a letter delivered to the ... 8-K filed on September 16, 2014.  PDL ... "We have received a number of inquiries on ...
(Date:9/17/2014)... N.J. , Sept. 17, 2014 Aethlon ... therapeutic devices to address infectious disease, cancer and other ... (ESI), disclosed today that each company will be presenting ... On September 18 th , Sahil Shah ... "Exosomes: A Multiplexed Platform for Clinical Management." ...
(Date:9/17/2014)... -- BioClinica®, Inc., a leading provider of outsourced clinical ... its experts are speaking at the 20th Annual ... held September 28 to October 1 in ... the innovative Compass technology, a risk-based monitoring ... earlier this year, is up for the Technology ...
Breaking Biology Technology:Oxides discovered by CCNY team could advance memory devices 2PDL BioPharma Issues Statement on Resignation of Ernst and Young as Corporate Auditors 2PDL BioPharma Issues Statement on Resignation of Ernst and Young as Corporate Auditors 3Aethlon Medical and Exosome Sciences To Present at the Exosomes & SingleCell Analysis Summit 2Aethlon Medical and Exosome Sciences To Present at the Exosomes & SingleCell Analysis Summit 3BioClinica to Present at 20th Annual SCDM Conference 2BioClinica to Present at 20th Annual SCDM Conference 3
... Recognition Algorithm Detects and Compensates for ... Irregularities and ... the addition of VeriEye iris recognition technology to the,company,s ... SDK features an advanced iris recognition,algorithm that rapidly detects ...
... Amsterdam,Molecular Therapeutics (Euronext: AMT), a leader in the ... obtained a license from ,TIGET, San,Raffaele Telethon Institute ... to prevent immune responses against gene therapy for ... development of AMT-060,(AMT,s AAV-based gene therapy for this ...
... Oncology-Baylor Charles A.,Sammons Cancer Center, a member of ... Award at the recent 44th American Society of,Clinical ... was one of,only 10 community oncology practices to ... consecutive year that practices affiliated with US,Oncology have ...
Cached Biology Technology:New VeriEye SDK from Neurotechnology Enables Development of Reliable, Cost-effective Biometric Iris Recognition Systems 2New VeriEye SDK from Neurotechnology Enables Development of Reliable, Cost-effective Biometric Iris Recognition Systems 3AMT Makes Important Advance in the Development of its Gene Therapy for Hemophilia B -Company Accesses Technology to Prevent Immune Response 2AMT Makes Important Advance in the Development of its Gene Therapy for Hemophilia B -Company Accesses Technology to Prevent Immune Response 3Texas Oncology-Baylor Sammons Cancer Center Recognized for Highest Commitment to Clinical Research at ASCO 2
... is essential for hunting and analyzing ... such as EST sequencing projects, microarrays, ... are not well suited for the ... TRIMMER kit, though, is specially developed ...
... SNP loci identification through targeting resequencing. ... design, intensive assay validation/optimization, high throughput ... or customer-supplied samples and sequence alignment ... for rapid and highly accurate identification ...
... Application: The Panorama Mouse/Rat Tissue Extract ... protein expression in various tissue extracts. The ... is detected using a protein specific antibody. ... binding is visualized by a sensitive chemiluminescent ...
... 6 delivers enhanced statistics and statistical ... quality improvement managers. As an accepted ... 6 simplifies statistics for novice users ... by experts. It offers a powerful ...
Biology Products: