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Niacin, the fountain of youth
Date:9/30/2013

Who would not want to live a long and healthy life? A freely available food supplement could help in this respect, scientists from ETH Zurich have demonstrated in roundworms. Vitamin B3 also known as niacin and its metabolite nicotinamide in the worms' diet caused them to live for about one tenth longer than usual.

As an international team of researchers headed by Michael Ristow, a professor of energy metabolism, has now experimentally demonstrated, niacin and nicotinamide take effect by promoting formation of so-called free radicals. "In roundworms, these reactive oxygen species prolong life," says Ristow.

"No scientific evidence for usefulness of antioxidants"

This might seem surprising as reactive oxygen species are generally considered to be unhealthy. Ristow's view also contradicts the textbook opinion championed by many other scientists. Reactive oxygen species are known to damage somatic cells, a condition referred to as oxidative stress. Particular substances, so-called antioxidants, which are also found in fruit, vegetables and certain vegetable oils, are capable of neutralising these free radicals. Many scientists believe that antioxidants are beneficial to health.

"The claim that intake of antioxidants, especially in tablet form, promotes any aspect of human health lacks scientific support," says Ristow. He does not dispute that fruit and vegetables are healthy. However, this may rather be caused by other compounds contained therein, such as so-called polyphenols. "Fruit and vegetables are healthy, despite the fact that they contain antioxidants," says the ETH-Zurich professor. Based on the current and many previous findings he is convinced that small amounts of reactive oxygen species and the oxidative stress they trigger have a health-promoting impact. "Cells can cope well with oxidative stress and neutralise it," says Ristow.

Substance mimics endurance sport

In earlier studies on huma
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Contact: Michael Ristow
michael-ristow@ethz.ch
41-446-557-446
ETH Zurich
Source:Eurekalert

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