Navigation Links
News tips from the journal mBio®, volume 4, issue 1
Date:3/14/2013

Disarming One of the Deadliest Pathogens

Francisella tularensis, the cause of tularemia and one of the deadliest respiratory pathogens in existence, is considered a potential biological weapon because it is readily aerosolized and exhibits a high degree of infectivity and lethality in humans. While a live attenuated vaccine strain has been developed, it remains unlicensed because scientists have been unable to understand the basis for its attenuated virulence. In an attempt to find an acceptable live attenuated vaccine strain, researchers from Harvard Medical School examined the mechanism behind one reason the pathogen is so lethal. The first line of defense against a bacterial pathogen is innate immunity, which slows the progress of infection to allow time for adaptive immunity to develop. F. tularensis suppresses the early innate immune response, allowing the pathogen to kill its host before adaptive immunity develops, using a specific lipopolysaccharide (LPS.) In this study the researchers show that a strain of the pathogen lacking this specific LPS is attenuated in mice and specifically elicits an innate immune response. When immunized with the strain, mice were protected against challenge by a highly virulent strain of the bacteria. This study has identified not only a novel LPS modification important for microbial virulence, but also offers a new vaccine candidate.

http://bit.ly/mbiotip0313a


Lessons from a Decade of Plague in a Port City

A cluster of human plague cases over a 10-year period in the seaport city of Mahajanga Madagascar after a 62-year plague-free period provided researchers from Arizona and Madagascar with an opportunity to study plague dynamics in an urban environment, especially since historically plague entered new geographic areas through port cities such as this. Most of the isolates found during t
'/>"/>

Contact: Jim Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Tips from the journal mBio
2. Canadian Journal of Cardiology publishes new atrial fibrillation guidelines
3. Flavor and the new Nordic cuisine: BioMed Centrals new scientific journal Flavor is launched
4. Elsevier launches new journal Algal Research
5. AGU journal highlights for March 29, 2012
6. AGU journal highlights for April 16, 2012
7. Elsevier selected as new publisher of the American Journal of Geriatric Psychiatry
8. New journal on disruptive science and technology launched by Mary Ann Liebert Inc. publishers
9. Wiley-Blackwell launches new open-access journal: Food Science & Nutrition
10. Special issue of the EMBO Journal celebrates 30 years of Wnt research
11. New peer-reviewed journal on big data launching in Fall 2012
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... at the University of Minnesota have developed an animal ... used for muscle regeneration research as well as studies ... The research is published in the current edition of ... no treatment for FSHD, which is thought by many ... FSHD is an unusual genetic disorder because, unlike most ...
(Date:8/28/2014)... compounds that could positively impact the global ... possible, thanks to researchers in Penn State,s ... suppository made from the seaweed-derived food ingredient ... Tenofovir provides a woman-initiated, drug-delivery vehicle that ... transmitted infections during unprotected heterosexual intercourse, the ...
(Date:8/28/2014)... new roads will be built worldwide by 2050. Many ... where they bring an influx of destructive loggers, hunters ... has created a ,global roadmap, for prioritising road building ... demands of development and environmental protection. , The map ... natural importance of ecosystems and a ,road-benefits, layer that ...
Breaking Biology News(10 mins):UMN researchers find animal model for understudied type of muscular dystrophy 2Sensory-tested drug-delivery vehicle could limit spread of HIV, AIDS 2Sensory-tested drug-delivery vehicle could limit spread of HIV, AIDS 3Study shows where on the planet new roads should and should not go 2Study shows where on the planet new roads should and should not go 3
... Hamilton, Nov. 11, 2013 Researchers at McMaster University have ... and it may serve as a way to measure injury. ... muscle damage biomarker," said Thomas Hawke, principal investigator and an ... at McMaster. "Regardless of the way in which ...
... after giving birth plays a big factor in the quantity and ... University of Missouri have found that subclinical hypocalcemia, which is the ... occurs in many cows after giving birth, is related to higher ... the MU College of Veterinary Medicine, says these higher levels of ...
... his sons less sensitive to the drug and thereby more ... animal study presented by Penn Medicine researchers at Neuroscience 2013, ... The study, led by Mathieu Wimmer, PhD, a post-doctoral researcher ... of Neuroscience in Psychiatry at the Perelman School of Medicine ...
Cached Biology News:Low levels of blood calcium in dairy cows may affect cow health and productivity, MU study finds 2Sons of cocaine-using fathers may resist addiction to drug, Penn Medicine study suggests 2
(Date:8/28/2014)... --  SunTrust Robinson Humphrey (STRH) today announced ... equity research team in biotechnology and oilfield services.  ... research demonstrates our commitment to providing our valued ... investment decision making," said Biff Woodruff , ... make significant investments in differentiated content at a ...
(Date:8/28/2014)... 2014 Scientists, researchers, and technologists will ... Laser Damage 2014 symposium. Marking its 46th year, ... will run 14-17 September. The event is sponsored by ... . , The premier conference for basic and applied ... optical materials will engage researchers and engineers from numerous ...
(Date:8/28/2014)... 28, 2014 Supplementing their complete ... promotion for Eppendorf Safe Lock Centrifuge Tubes ... the highest quality tubes at an affordable price. ... customers doing chemical, medical, pharmaceutical, and life science ... not regularly able to afford Eppendorf products. , ...
(Date:8/27/2014)... 2014 Rhythm, a biopharmaceutical company developing peptide ... result in metabolic disorders, announced today that it has ... U.S. Securities and Exchange Commission (SEC) relating to the ... stock. The number of shares to be offered and ... been determined. Citigroup and Cowen and Company ...
Breaking Biology Technology:SunTrust Robinson Humphrey Expands Equity Research in Healthcare and Energy 2SunTrust Robinson Humphrey Expands Equity Research in Healthcare and Energy 3Laser Damage to Draw Researchers, Engineers, Scientists to 46th Annual Conference 2Laser Damage to Draw Researchers, Engineers, Scientists to 46th Annual Conference 3Eppendorf Safe Lock Centrifuge Tube Promotion Now Available at Major Pipette Distributor Pipette.com 2Eppendorf Safe Lock Centrifuge Tube Promotion Now Available at Major Pipette Distributor Pipette.com 3Rhythm Files Registration Statement for Proposed Initial Public Offering 2
...
... 3T3 cells were cultured in DMEM with 4 ... of growth. In order to keep the ... in acetone-methanol. The cells are arrayed on ... each wells surface specifically treated to enhance cellular ...
... Systems provide rapid, precise localization of ... frozen or paraffin-embedded tissue, cytospins and ... facilitate double or triple labeleing experiments, ... with primary antibodies of different animal ...
... GC content or with significant secondary structure ... when subjected to PCR result in little ... can be increased by the addition of ... is an effective PCR enhancer for GC-rich ...
Biology Products: