Navigation Links
News tips from the journal mBio®, volume 4, issue 1
Date:3/14/2013

Disarming One of the Deadliest Pathogens

Francisella tularensis, the cause of tularemia and one of the deadliest respiratory pathogens in existence, is considered a potential biological weapon because it is readily aerosolized and exhibits a high degree of infectivity and lethality in humans. While a live attenuated vaccine strain has been developed, it remains unlicensed because scientists have been unable to understand the basis for its attenuated virulence. In an attempt to find an acceptable live attenuated vaccine strain, researchers from Harvard Medical School examined the mechanism behind one reason the pathogen is so lethal. The first line of defense against a bacterial pathogen is innate immunity, which slows the progress of infection to allow time for adaptive immunity to develop. F. tularensis suppresses the early innate immune response, allowing the pathogen to kill its host before adaptive immunity develops, using a specific lipopolysaccharide (LPS.) In this study the researchers show that a strain of the pathogen lacking this specific LPS is attenuated in mice and specifically elicits an innate immune response. When immunized with the strain, mice were protected against challenge by a highly virulent strain of the bacteria. This study has identified not only a novel LPS modification important for microbial virulence, but also offers a new vaccine candidate.

http://bit.ly/mbiotip0313a


Lessons from a Decade of Plague in a Port City

A cluster of human plague cases over a 10-year period in the seaport city of Mahajanga Madagascar after a 62-year plague-free period provided researchers from Arizona and Madagascar with an opportunity to study plague dynamics in an urban environment, especially since historically plague entered new geographic areas through port cities such as this. Most of the isolates found during t
'/>"/>

Contact: Jim Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Tips from the journal mBio
2. Canadian Journal of Cardiology publishes new atrial fibrillation guidelines
3. Flavor and the new Nordic cuisine: BioMed Centrals new scientific journal Flavor is launched
4. Elsevier launches new journal Algal Research
5. AGU journal highlights for March 29, 2012
6. AGU journal highlights for April 16, 2012
7. Elsevier selected as new publisher of the American Journal of Geriatric Psychiatry
8. New journal on disruptive science and technology launched by Mary Ann Liebert Inc. publishers
9. Wiley-Blackwell launches new open-access journal: Food Science & Nutrition
10. Special issue of the EMBO Journal celebrates 30 years of Wnt research
11. New peer-reviewed journal on big data launching in Fall 2012
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... the first smartphone app that automatically reveals students, ... other words, your smartphone knows your state of ... how that affects you. , The StudentLife app, ... to their academic performance, also may be used ... monitor mental health, trigger intervention and improve productivity ...
(Date:9/18/2014)... celebrated tonight at the third annual Golden Goose Award ... premature infants and in paving the way for the ... supported by the National Science Foundation, the National Institutes ... be honored at a ceremony at the Library of ... of Congress will be on hand to help present ...
(Date:9/18/2014)... when people are too stressed they are often grouchy, ... Mind Institute (BMI) at EPFL have just highlighted a ... stress and the loss of social skills and cognitive ... synaptic regulatory molecule in the brain. This was revealed ... , Carmen Sandi,s team went to look for ...
Breaking Biology News(10 mins):New Dartmouth smartphone app reveals users' mental health, performance, behavior 2New Dartmouth smartphone app reveals users' mental health, performance, behavior 3New Dartmouth smartphone app reveals users' mental health, performance, behavior 43rd annual Golden Goose award ceremony honors 8 researchers; Unusual work had big results 2How stress tears us apart 2
... April 27 Negotiations broke off early Tuesday morning between Temple ... (PASNAP) following a 14-hour session.  Talks are expected to resume later today at ... Continued progress was reported, but ... , Temple ...
... Holdings, Inc. (NYSE: MDC ) today announced that its board of directors has ... share on the Company,s common stock.  The dividend will be paid on Wednesday, May ... , , ... , , ...
... , April 26 /PRNewswire-Asia/ -- Winner Medical ... "Company"), a leading manufacturer of,medical dressings, medical disposables and ... announced today that it has,priced a public offering of ... of, $6.10 per share. Winner Medical expects to ...
Cached Biology News:M.D.C. Holdings Declares Quarterly Cash Dividend 2Winner Medical Group inc. Prices Offering of 1,380,000 Shares of Common Stock 2Winner Medical Group inc. Prices Offering of 1,380,000 Shares of Common Stock 3Winner Medical Group inc. Prices Offering of 1,380,000 Shares of Common Stock 4
(Date:9/18/2014)... 18, 2014  MEI Pharma, Inc. (Nasdaq: MEIP ... novel therapies for cancer, announced today that Daniel P. ... at BioCentury,s NewsMakers in the Biotech Industry conference ... from the Millennium Broadway Hotel & Conference Center in ... presentation can be accessed at www.meipharma.com . A replay ...
(Date:9/18/2014)... 18, 2014 OMICS Group International ... to participate in the ‘Open Access Week’ by ... OMICS Group Pharma Journals from 20-26th ... the fastest emerging Sciences, accelerating with a tremendous ... across the globe. The industry is gearing with ...
(Date:9/18/2014)... USC have developed a new microscopy technology that ... animals at higher-than-ever resolution. , Dubbed "Complementation Activated ... resolutions that are an order of magnitude finer ... the behavior of biomolecules at the nanometer scale. ... by Nature Communications , the researchers behind ...
(Date:9/18/2014)... City, MX (PRWEB) September 18, 2014 ... in Mexico City, MX. ASEA is the manufacturer of ... and the skin care product, RENU28. , The ... Regional Vice President Duvan Botero, and ASEA Field Leader ... Samuelson holds a PhD in Atomic/Medical Physics from the ...
Breaking Biology Technology:MEI Pharma To Present At BioCentury's NewsMakers Conference 2MEI Pharma To Present At BioCentury's NewsMakers Conference 3Pharma and Omics Journals to Address Global Challenges during Open Access Week 2Pharma and Omics Journals to Address Global Challenges during Open Access Week 3Scientists pioneer microscopy technique that yields fresh data on muscular dystrophy 2Announcing the ASEA Mexico Grand Opening Tour Beginning September 18th 2
... Aug. 18 Sigma-Aldrich® Corporation (Nasdaq: SIAL ... been named Vice President and Chief Information Officer, effective ... lead the Company,s global information systems function and will ... Officer and Chief Administrative Officer. Borg (age ...
... 18 NephRx Corporation today announced that the U.S. ... designation to its lead product NX001 for the prevention ...  NX001 is a kidney growth factor peptide that has ... models of acute renal failure.   "Delayed ...
... FutureFuel Corp. (OTC Bulletin Board: FTFL ) filed ... special cash dividend of $0.20 per share. The ... a special cash dividend of U.S. $0.20 per share on ... 2010. The dividend is payable September 30, 2010. ...
Cached Biology Technology:Sigma-Aldrich Announces Appointment of Magnus Borg as Vice President and Chief Information Officer (CIO) 2NephRx Corp. Receives Orphan Drug Designation for NX001 for Prevention of Delayed Kidney Graft Function 2
Rabbit polyclonal to Leucyl tRNA synthetase ( Abpromise for all tested applications). Antigen: L930-H1176 denatured human recombinant LRS. Entrez Gene ID: 3926 Swiss Protein ID: Q9P2J5...
Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2). [Source:Uniprot/SWISSPROT;Acc:P19878] Antigen: Recombinant Protein E...
... Rabbit polyclonal to FANCM ( Abpromise ... Antigen: Synthetic peptide derived from ... Human FANCM. (Note: the amino acid ... available as ab27787 .) ...
Rabbit polyclonal to 13,14 dihydro 15 keto Prostaglandin E2 ( Abpromise for all tested applications)....
Biology Products: