Navigation Links
News tips from the Journal of Neuroscience
Date:8/14/2007

Spontaneous Astrocytic Ca2+ Oscillations and Neurite Growth
Kazunori Kanemaru, Yohei Okubo, Kenzo Hirose, and Masamitsu Iino

This week, Kanemaru et al. explore the signaling pathway between spontaneous Ca2+ oscillations in cultured astrocytes and the promotion of neurite growth. Their results reveal a role for the membrane-bound adhesion molecule N-cadherin. The authors blocked Ca2+ oscillations by preventing IP3 signaling with retroviral-mediated expression of IP3 5-phosphatase (5ppase). This molecule hydrolyzes IP3 and thus prevented spontaneous astrocytic Ca2+ oscillations. Growth cone motility was compromised in hippocampal neurons cultured with 5ppase-expressing astrocytes. Interference with neurotransmitter-evoked astrocytic Ca2+ transients did not affect neurite outgrowth. The messenger was not diffusible because direct contact with an astrocyte deficient in spontaneous Ca2+ signaling arrested growth cone advancement. Surface expression of the growth-promoting molecule N-cadherin was downregulated in 5ppase-expressing astrocytes, and neuronal growth cone advancement was rescued by extrinsic expression of N-cadherin on astrocytes.


Forming Filopodia
Yutaka Furutani, Hitomi Matsuno, Miwa Kawasaki, Takehiko Sasaki, Kensaku Mori, and Yoshihiro Yoshihara

Before synapses form between axons and dendrites, even before dendritic spines take shape, dendritic filopodia are out there, poking and prodding and exploring their surroundings. In this weeks Journal, Furutani et al. searched for intracellular binding partners for telencephalin (TLCN), atelencephalon- and dendrite-specific cell adhesion molecule that is expressed in filopodia. A yeast two-hybrid screen revealed interactions with ezrin, radixin, and moesin of the so-called ERM family; these adaptors link membrane proteins to the actin cytoskeleto
'/>"/>

Contact: Sara Harris
sharris@sfn.org
202-962-4000
Society for Neuroscience
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. UCLA Study Shows One-Third of Drug Ads in Medical Journals Do Not Contain References Supporting Medical Claims
2. Recent breakthroughs in common adult leukemia highlighted in New England Journal of Medicine
3. Leukemia Drug Breakthrough Study In New England Journal Of Medicine
4. Open Access journals get impressive impact factors
5. Funding and bureaucracy, not access to journals, are chief obstacles to scientific productivity
6. New journal article urges use of animal serum-free media for growing live cells
7. Impressive new Impact Factors for BioMed Centrals open-access journals
8. Public Library of Science to launch new, open access journal on neglected tropical diseases
9. Are journal rankings distorting science?
10. NIH neuroscience microarray consortium launches high-throughput genotyping services
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2015)... 24, 2015   NexID Biometrics LLC, whose ... needs, today announced the beginning of shipments of version ... The company, based in Potsdam, N.Y. ... Connect:ID Expo, which began here today at the Walter ... 2.0 of its SDK boosts the accuracy rate range ...
(Date:3/23/2015)... 23, 2015  In the 2014 fiscal year, irs.gov ... losses. This figure accounts for a fraction of the ... Nilson Report, exceeds $11 billion globally. The polygraph has ... crime has occurred. Investor Mark Saint Juste ... Joe Paolella partnered to administer the test in ...
(Date:3/20/2015)... OXFORD, Conn. , March 20, 2015 ... "Company"), a biometric authentication company focused on the growing ... Wocket® smart wallet is one of the products featured ... today, March 20th at 11:00 PM EST on the ... travels to Las Vegas , site ...
Breaking Biology News(10 mins):NexID Begins Shipments Of Version 2.0 Fake-Finger-Detection Solution 2Polygraph Test Now Used to Protect Investors From Fraud 2Polygraph Test Now Used to Protect Investors From Fraud 3NXT-ID's Wocket Biometric Smart Wallet to Air on "I Want That" International CES Special 2NXT-ID's Wocket Biometric Smart Wallet to Air on "I Want That" International CES Special 3
... Early in development infants of many species experience important ... of their mother to start exploring the wider world. ... brain during that turning point. Based on animal ... of attachments in many speciesincluding the conundrum of why ...
... firepower and fresh physical perspectives to combat cancer, the National ... Microenvironment and Metastasis, which will be headquartered at Cornell University. ... nation being announced today (Oct. 26, 2009) by the NCI. ... Cornell will serve as the lead institution in a partnership ...
... (October 26, 2009): An experimental drug, LX211 (LUVENIQ; oral ... of modifying the course of uveitis, a group of ... loss or substantial morbidity from steroid use. Results of ... to be the subject of two podium presentations at ...
Cached Biology News:Changes in brain chemicals mark shifts in infant learning 2Changes in brain chemicals mark shifts in infant learning 3Battling cancer with engineering: NCI funds new $13 million cancer research center led by Cornell 2Battling cancer with engineering: NCI funds new $13 million cancer research center led by Cornell 3LX211 highlighted as potential disease modifying therapy for non-infectious uveitis 2LX211 highlighted as potential disease modifying therapy for non-infectious uveitis 3
(Date:4/23/2015)... FOREST, Calif. , April 23, 2015 /PRNewswire/ ... of advanced cryogenic logistics solutions for the life ... further established its cryogenic logistics solutions within the ... agreement with Yancey Farms to support the shipment ... German Sport horse Stallions. ...
(Date:4/23/2015)... April 23, 2015  Metanome, Inc., an industry ... company has changed its name to Diversigen, Inc.  ... as the single commercial source for the myriad ... on the diverse opportunities of the microbiome.  From ... accepts – including those that are difficult to ...
(Date:4/22/2015)... , April 23, 2015  The Heinz Family ... th Heinz Awards, which will present unrestricted ... Americans for their creativity and determination in finding ... This year,s recipients include a prolific ... modern-day life and personal relationships; two former Marines ...
(Date:4/22/2015)... 2015 Steep Hill, the industry leader ... it has opened an investment round of $5 ...  The common stock investment round will be offered ... intended to encourage funding of small businesses by ... businesses largely relied on friends and family, venture ...
Breaking Biology Technology:Cryoport to Support the Equine Animal Husbandry Market Through Agreement with Yancey Farms 2Cryoport to Support the Equine Animal Husbandry Market Through Agreement with Yancey Farms 3Metanome Announces Corporate Name Change to Diversigen 2From a Scientist Who Develops Human Microlivers to a New Yorker Cartoonist Who Masterfully Depicts the Humor and Heartbreak of Everyday Life: The 20th Heinz Awards Honors Six Changemakers 2From a Scientist Who Develops Human Microlivers to a New Yorker Cartoonist Who Masterfully Depicts the Humor and Heartbreak of Everyday Life: The 20th Heinz Awards Honors Six Changemakers 3From a Scientist Who Develops Human Microlivers to a New Yorker Cartoonist Who Masterfully Depicts the Humor and Heartbreak of Everyday Life: The 20th Heinz Awards Honors Six Changemakers 4From a Scientist Who Develops Human Microlivers to a New Yorker Cartoonist Who Masterfully Depicts the Humor and Heartbreak of Everyday Life: The 20th Heinz Awards Honors Six Changemakers 5From a Scientist Who Develops Human Microlivers to a New Yorker Cartoonist Who Masterfully Depicts the Humor and Heartbreak of Everyday Life: The 20th Heinz Awards Honors Six Changemakers 6Steep Hill Launches $5M Limited Stock Offering 2Steep Hill Launches $5M Limited Stock Offering 3
... you can wrap around your wrist? Such a thing may ... Tour, whose lab has developed transparent, flexible memories using silicon ... in a talk at the national meeting and exposition of ... type of memory could combine with the likes of transparent ...
... JOSE, Calif., March 30, 2012  Human Pheromone Sciences, Inc. (EROX) ... SEC.  The Company filed a Form 15 with the SEC ... common stock under the Securities Exchange Act of 1934.  Upon ... file periodic and current reports with the SEC, including Forms ...
... M.D., FSIR, an interventional radiologist and head of the ... MD Anderson Cancer Center in Houston, assumed office as ... during its 37th Annual Scientific Meeting in San Francisco, ... scientists and allied health professionals dedicated to improving health ...
Cached Biology Technology:Human Pheromone Sciences Voluntarily Files With SEC for Termination of Registration 2Human Pheromone Sciences Voluntarily Files With SEC for Termination of Registration 3Human Pheromone Sciences Voluntarily Files With SEC for Termination of Registration 4Human Pheromone Sciences Voluntarily Files With SEC for Termination of Registration 5Society of Interventional Radiology Names Marshall Hicks, M.D., FSIR, as 2012-13 President 2Society of Interventional Radiology Names Marshall Hicks, M.D., FSIR, as 2012-13 President 3
... new StrepMAB-Immo coated microplates can be used ... SerAla-Strep-tag II fusion proteins for ELISA or ... amounts of such proteins are bound with ... on the left) and will not elute ...
... PAL label printer is portable, easy-to-use and makes ... Portable/Handheld Easy to use ... vial and slide sizes Time/Date stamp ... needs one Serialization feature makes you ...
Activating Agents, 7-azabenzotriazol-1-yloxy-tris-(pyrrolidino)phosphonium hexafluorophosphate...
Each 72-well MiniTray is low profile, with lid. Conical well shape, 10 l....
Biology Products: