Navigation Links
Newly identified small-RNA pathway defends genome against the enemy within
Date:3/16/2014

within, the cell has devised stringent mechanisms to maintain tight control over transposon activity. The primary mechanism is the epigenetic code, a kind of secondary layer of genetic information that determines how our DNA is used. Epigenetic marks decorate human DNA, delineating active and inactive genes. Regions of the genome that are rich in transposons are heavily marked with inactivating signals, which silence transposons.

The problem for plants, in particular, is that some cells eliminate nearly all epigenetic marks during reproduction. "The loss of these marks puts the cell in tremendous danger, especially at critical times like reproduction," says CSHL postdoctoral fellow Kate Creasey, Ph.D., lead author on the paper appearing in Nature today. "There must be another mechanism to prevent this kind of widespread genomic disruption."

The CSHL team discovered a pathway that does precisely this. The pathway they describe acts as a fail-safe to prevent transposon damage when epigenetic silencing is lost. The cell uses small RNAs, known as microRNAs, to accomplish the task. MicroRNAs were already known to regulate gene expression during development. "Now we show that microRNAs actually target transposons when they are activated, for example in the germline (or reproductive cells)," says Martienssen. "This hints that they may have evolved as a transposon defense mechanism."

Working in collaboration with Professor Blake Meyers at the University of Delaware, Martienssen and his colleagues found that microRNAs silence transposons through a new class of small RNAs known as easiRNAs. Animals have a similar transposon defense mechanism, says Martienssen. "The pathway we have discovered parallels with small RNA systems in animal germlines (called piwi-interacting RNAs, or piRNAs) which also protect against transposons when the genome is being reprogrammed."


'/>"/>

Contact: Jaclyn Jansen
jjansen@cshl.edu
516-367-8455
Cold Spring Harbor Laboratory
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Newly discovered catalyst could lead to the low-cost production of clean methanol
2. Newly discovered marsupial the victim of fatal attraction
3. Newly discovered signaling pathway could impact a variety of autoinflammatory diseases
4. Newly discovered human peptide may become a new treatment for diabetes
5. Attention Vical Incorporated Investors: Vical Misled Investors According to a Newly Filed Class Action
6. Newly identified proteins make promising targets for blocking graft-vs.-host disease
7. UF: Newly discovered tiger shark migration pattern might explain attacks near Hawaii
8. Newly discovered ocean plume could be major source of iron
9. Newly discovered switch plays dual role in memory formation
10. Newly discovered bacterial partnership changes ocean chemistry
11. ACLS Online Renewal Course from United Medical Education Now Features Newly-Updated Course Materials
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Newly identified small-RNA pathway defends genome against the enemy within
(Date:8/25/2015)... and BELLEVUE, Wash. , Aug. ... advanced robotic systems, announced today it will unveil its ... vehicle (UGV), at the National Tactical Officers Association Conference ... The Guardian S is the first-ever commercially available ... years of research and in-field trials and is protected ...
(Date:8/24/2015)... Calif. , Aug. 24, 2015  Based on its ... recognizes DERMALOG with the 2015 African Biometrics Company of the ... has achieved substantial commercial success in Africa ... , where it has implemented one of the largest ... banks as well as the Central Bank of ...
(Date:8/20/2015)... Aug. 20, 2015   Sensory, Inc ., ... the user experience and security of consumer electronics ... announced that its TrulySecure™ is the ... to be FIDO Certified™. The FIDO ... with the FIDO UAF (Universal Authentication Framework) 1.0 ...
Breaking Biology News(10 mins):Sarcos to Debut First-of-its-Kind Snake Robot 2Sarcos to Debut First-of-its-Kind Snake Robot 3Frost & Sullivan Applauds DERMALOG's Rise as the Supplier of Best-in-class Biometric Solutions in Africa 2Frost & Sullivan Applauds DERMALOG's Rise as the Supplier of Best-in-class Biometric Solutions in Africa 3Frost & Sullivan Applauds DERMALOG's Rise as the Supplier of Best-in-class Biometric Solutions in Africa 4Frost & Sullivan Applauds DERMALOG's Rise as the Supplier of Best-in-class Biometric Solutions in Africa 5Frost & Sullivan Applauds DERMALOG's Rise as the Supplier of Best-in-class Biometric Solutions in Africa 6TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 2TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 3TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 4TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 5
... A protein that seems to be pivotal in lifting ... funded by the National Institutes of Health's National Institute ... this protein, called p11, display depression-like behaviors, while those ... treated with antidepressants," explained Paul Greengard, Ph.D., a Rockefeller ...
... becoming more prevalent in many intensive care units, according ... Clinical Infectious Diseases, now available online. , Methicillin-resistant Staphylococcus ... that patients often acquire in the hospital. Skin infections ... the heart, the lungs, and the digestive tract. The ...
... associated with Alzheimer's disease in the brain of the ... neuronal death and proteins previously associated with cancer. , ... and colleagues from Brigham and Women's Hospital, Harvard Medical ... brain generally do not divide. It is therefore perplexing ...
Cached Biology News:Nobelist discovers antidepressant protein in mouse brain 2Nobelist discovers antidepressant protein in mouse brain 3Drug-resistant bacteria patterns in intensive care units changing nationally 2
(Date:8/28/2015)... ... August 28, 2015 , ... ... studies at the International Spine Intervention Society’ s 23rd Annual Scientific ... August 1st, 2015. With a focus on evidence-based research and clinical application, the ...
(Date:8/28/2015)... Texas (PRWEB) , ... August 28, 2015 , ... ... Riordan, PhD and orthopedic surgeon, Wade McKenna, DO, announced today that the use ... Dallas, Texas, resulted in complete healing of an otherwise non-healing surgical knee wound. ...
(Date:8/27/2015)... ... ... Capital Edge Consulting , a nationwide consulting firm that specializes in ... as one of the top 5000 companies listed on the 2015 Inc. 5000 ... “It is truly an honor to be recognized as one of America’s fastest growing ...
(Date:8/27/2015)... , Aug. 27, 2015 The ... a patient,s eyes—and life—were saved by doctors at Vanderbilt ... working with NNFF, NovaBay Pharmaceuticals and Dr. John ... Center at Seton Medical Center in ... treatment used a breakthrough approach, pioneered by Dr. Crew, ...
Breaking Biology Technology:Proove Biosciences Presents New Research Study at the International Spine Intervention Society’s Annual Scientific Meeting 2Proove Biosciences Presents New Research Study at the International Spine Intervention Society’s Annual Scientific Meeting 3Proove Biosciences Presents New Research Study at the International Spine Intervention Society’s Annual Scientific Meeting 4Dallas-Fort Worth Stem Cell Researchers Use Amniotic Tissue To Successfully Treat Non-Healing Surgical Wound 2Dallas-Fort Worth Stem Cell Researchers Use Amniotic Tissue To Successfully Treat Non-Healing Surgical Wound 3Dallas-Fort Worth Stem Cell Researchers Use Amniotic Tissue To Successfully Treat Non-Healing Surgical Wound 4Capital Edge Consulting Makes Inc. 5000 List of America’s Fastest-Growing Private Companies 2Capital Edge Consulting Makes Inc. 5000 List of America’s Fastest-Growing Private Companies 3Patient's Life and Eyes Saved from Gruesome Flesh-Eating Infection Consuming Her Face 2Patient's Life and Eyes Saved from Gruesome Flesh-Eating Infection Consuming Her Face 3
... May 10 BioMed Realty Trust, Inc. (NYSE: BMR ... held on Tuesday, May 11, 2010 at BioMed,s The Landmark at ... presentations by Alan D. Gold , Chairman and Chief Executive Officer, and ... , , ...
... PLYMOUTH MEETING, Pa. , May 10 ... "Company") today announced,financial results for the first quarter ended March 31, ... ... stated, "This was a,quarter of successful management transition at Sunstone. We replaced ...
... ... electronic data capture system , ... Waltham, MA (PRWEB) May 10, 2010 -- Akaza Research announces the availability of the ... resource that helps OpenClinica users find, share, and re-use clinical trial case report forms. It ...
Cached Biology Technology:BioMed Realty Trust to Webcast Company Presentation at Investor Day 2010 2BMP Sunstone Reports First Quarter 2010 Financial Results 2BMP Sunstone Reports First Quarter 2010 Financial Results 3BMP Sunstone Reports First Quarter 2010 Financial Results 4BMP Sunstone Reports First Quarter 2010 Financial Results 5BMP Sunstone Reports First Quarter 2010 Financial Results 6BMP Sunstone Reports First Quarter 2010 Financial Results 7BMP Sunstone Reports First Quarter 2010 Financial Results 8BMP Sunstone Reports First Quarter 2010 Financial Results 9BMP Sunstone Reports First Quarter 2010 Financial Results 10BMP Sunstone Reports First Quarter 2010 Financial Results 11BMP Sunstone Reports First Quarter 2010 Financial Results 12OpenClinica Case Report Form Library Now Available 2OpenClinica Case Report Form Library Now Available 3OpenClinica Case Report Form Library Now Available 4
Polyclonal Antibody to AHI1 / Jouberin...
Request Info...
Peptide-affinity Purified Polyclonal Antibody to SMAD7 Peptide with sequence SSCPCWLEVIFNSR, from C Terminus of the protein sequence according to NP_005895....
Polyclonal Antibody to PRG3...
Biology Products: